Curriculum Vitae

Mingkui Chen, M.D., Ph.D.

Department of Pathology

Oregon Health and Science University

**** ** *** ******* **** Rd, Mail Code L-113

Portland, OR 97239

ablvjv@r.postjobfree.com

cell: 402-***-****

PATHOLOGY EXPERIENCE/TRAINING

07/2010-date Surgical Pathology Fellow

Oregon Health and Science University, Portland, OR

07/2006-06/2010 AP/CP Pathology Resident

Chief Resident (07/2008-06/2010)

Creighton University, Omaha, NE

09/1995-07/1998 Nephrology/Renal Pathology Resident

Jinling Hospital, Nanjing, China

09/1991-07/1992 Pathology Student Fellow

Nanjing University School of Medicine, Nanjing,

China

EDUCATION:

Graduate:

09/1999-05/2002 Ph.D. University of Maryland at Baltimore

Dissertation: Ion channel studies on native reactive

astrocytes from adult rat brain.

Medical:

09/1988-07/1995 M.D. Nanjing University School of Medicine

Thesis: Morphometric studies on renal biopsy tissues

from patients of epidemic hemorrhagic fever.

RESEARCH EXPERIENCE:

10/2003 - 06/2006 Assistant Professor, University of Maryland at

Baltimore

07/2002 - 09/2003 Post Doctoral Research Fellow, University of

Maryland at Baltimore

09/1998 - 08/1999 Research Specialist, Bioniche Pharmaceutics Inc.,

Canada

CERTIFICATION AND LICENSURE:

American Board of Pathology: AP/CP (08/05/2010)

Nebraska Medical License: 25590

Educational Commission for Foreign Medical Graduates (ECFMG) Certificate: 0-

663-367-1

NPI: 191*******

DEA BC9852446 (expires 8/31/2012)

Oregon Postgraduate License: 84761 (expires 07/31/2011)

BCLS (expires 03/2012)

HONORS AND AWARDS:

05/2009 Resident of the Year, Department of Pathology, Creighton

University

09/2000 American Society of Clinical Pathologists, Regional Associate

Member Award

09/1998 Bioniche International Research Award, Canada

05/1997 Excellent Teaching Award, Nanjing University, China

RESEARCH GRANT AWARDS:

01/01/2005-12/31/2005 PI Potassium Channels in Neurofibromatosis-1

Department of Defense NF043080

$100,000

09/15/2004-04/30/2008 Co-invest Reactive astrocytes from gliotic capsule

National Institute of Health 1R01NS048260-

01

$786,250

03/01/2002-04/01/2007 Co-invest Ion Channel function/regulation in

astrocytes activated by CNS injury

Department of Veterans Affairs 003-40-

4111

$671,700

TEACHING EXPERIENCE:

Medical School Teaching:

2007-2010 Creighton University. IDC279 Case Studies in Medicine (M-2

medical students, small group sessions)

2006-2010 Creighton University. PTG467 Survey of Pathology Practice (M-4

medical students, elective, 6 students yearly). Introductory

sessions of the practice of clinical and anatomic pathology.

2006-2010 Creighton University. PTG461 Introduction to Pathology Practice

(M-4 medical students, elective, 9 students yearly). Provide

daily guidance in gross description, microscopic evaluation and

diagnosis.

1995-1998 Nanjing University. Immunology and Microbiology. Lecturer and

Lab Instructor. Teaching M-2 medical students of Medical

Immunology & Microbiology and instructing labs.

Non-Medical School Teaching:

2008-2010 Creighton University. PTG105 Introduction to Human Disease

(School of Pharmacy and Allied Health, 150 students on-campus

and 60 students web-based, lecturer and mentor)

2007-2008 Creighton University. Anatomy Graduate Students (17 students,

Jan - May, daily). Shadow grossing procedures and techniques

Interdisciplinary Teaching

2006-2010 Creighton University. Tumor Board Interdisciplinary Patient

Care Conference (weekly conference involving Surgery, Pathology,

and Radiology)

2006-2010 Creighton University. Conduction and Presentation of Pathology

Component

2006-2010 Creighton University. Hospital Grand Rounds Presentations

PUBLICATIONS AND PRESENTATIONS:

Peer Reviewed Papers:

Hu Q, Popa I, Fu K, Chen M, Chan WC (2007) Clonal CD8+ lymphocytic

proliferation associated by Epstein-Barr virus infection mimicking T-

cell leukemia. Leuk Lymphoma 48:1651-1653.

Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V (2007). Brain

oedema in focal ischemia: molecular pathophysiology and theoretical

implications. Lancet Neurol 6:258-268.

Sun Y, Chen M, Lowentritt BH, Van Zijl PS, Koch KR, Keay S, Simard JM,

Chai TC (2007). EGF and HB-EGF modulate inward potassium current in

human bladder urothelial cells from normal and interstitial cystitis

patients. Am J Physiol Cell Physiol 292:104-114.

Simard JM, Chen M, Tarasov KV, Bhatta S, Ivanova S, Melnitchenko L,

Tsymbalyuk N, West GA, Gerzanich V (2006) Newly expressed SUR1-

regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic

stroke. Nat Med 12: 433-440.

Simard JM, Chen M (2004) Regulation by sulfonylurea receptor type 1 of

a non-selective cation channel involved in cytotoxic edema of reactive

astrocytes. J Neurosurg Anesthesiol 16: 98-99.

Rama Rao KV, Chen M, Simard JM, Norenberg MD (2003) Increased aquaporin-

4 expression in ammonia-treated cultured astrocytes. Neuroreport 14:

2379-2382.

Rama Rao KV, Chen M, Simard JM, Norenberg MD (2003) Suppression of

ammonia-induced astrocyte swelling by cyclosporin A. J Neurosci Res 74:

891-897.

Chen M, Dong Y, Simard JM (2003) Functional coupling between

sulfonylurea receptor type 1 and a nonselective cation channel in

reactive astrocytes from adult rat brain. J Neurosci 23: 8568-8577.

Dalton S, Gerzanich V, Chen M, Dong Y, Shuba Y, Simard JM (2003)

Chlorotoxin-sensitive Ca2+-activated Cl- channel in type R2 reactive

astrocytes from adult rat brain. Glia 42: 325-339.

Perillan PR, Chen M, Potts EA, Simard JM (2002) Transforming growth

factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via

phospholipase C and protein kinase C-delta in reactive astrocytes from

adult rat brain. J Biol Chem 277: 1974-1980.

Chen M, Simard JM (2001) Cell swelling and a nonselective cation

channel regulated by internal Ca2+ and ATP in native reactive

astrocytes from adult rat brain. J Neurosci 21: 6512-6521.

Chen M, Jones DL (2000) Age- and myopathy-dependent changes in

connexins of normal and cardiomyopathic Syrian hamster ventricular

myocardium. Can J Physiol Pharmacol 78: 669-678.

Perillan PR, Li X, Potts EA, Chen M, Bredt DS, Simard JM (2000) Inward

rectifier K channel Kir2.3 (IRK3) in reactive astrocytes from adult

rat brain. Glia 31: 181-192.

Chen M, Chen H, Li L (1995) Can primary hypertension lead to renal

failure? Jiangsu Med J 21:707-708. (in Chinese)

Chen H, Chen M (1995) Renal pathological alterations during heart

diseases. Chinese J Nephrol Dial Transplant 4:143-151. (in Chinese)

Chen M, Chen H (1995) The role of macrophages in the damage of

glomerulus. Chinese J Nephrol Dial Transplant 4:134-138. (in Chinese)

Zheng F, Li L, Xiao S, Tang B, Chen M, Gao X, Ding B, Qiu S, Han M

(1995) Effects of Cordiceps sinesis in renal damage of epidemic

hemorrhagic fever. Chinese J Nephrol Dial Transplant 4:103-107. (in

Chinese)

Chen M, Chen H (1995) Crescent glomerulonephritis and renal failure

associated with non-Hodgkin's malignant lymphoma: a case report.

Chinese J Nephrol Dial Transplant 4:93-94. (in Chinese)

Chen H, Chen M (1995) Hereditary abnormalities of renal basement

membrane. Chinese J Nephrol Dial Transplant 4:40-47. (in Chinese)

Chen M (1994) Primary hypertension and end stage renal diseases (ESRD):

is there any relationship? Chinese J Nephrol Dial Transplant 3:547-548.

(in Chinese)

Chen M, Yao J (1994) Involvement of epidermal growth factor in acute

renal failure. Chinese J Nephrol Dial Transplant 3:394-397. (in

Chinese)

Zhang T, Zhou X, Chen M, Xu Y (1993) Morphometric studies on fat-

storing cells and Kupffer cells in liver with chronic viral hepatitis.

Jiangsu Med J 19:4-6. (in Chinese)

Li X, Zhao X, Yang X, Chen J, Chen M, Zhang Z, Huang F, Shi Q, Zhang T

(1992) Mitochondria calcium and phosphorus accumulation in some brain

regions in global cerebral ischemia and reperfusion. In: Metal Ions in

Biology and Medicine, vol. 2 (J. Anastassopoulou et al., ed), pp.299-

303. Paris: John Libbey Eurotext.

Patents:

J. Marc Simard & Mingkui Chen. A Novel Non-selective Cation Channel in

Neural Cells and Methods for Treating Brain Swelling. US Patent

Application10/391,561. Publication No. US-200*-*******-A1.

Online Journal Articles:

Repertinger SK, Santos EE, Chen M, Sarma DP (2009) Intravascular

Capillary Hemangioma of the Skin. The Internet J Dermatol 7(1).

Sarma DP, Chen M, Wang B (2007) Chondroma cutis. The Internet J

Dermatol 6(1).

Chen M, Bruno E, Santos EE, Sarma DP (2007) A brief review of the

"vulgaris" lesions of the skin. The Internet J Dermatol 6(1).

Chen M, Wang B (2007). Intranuclear inclusion bodies in the epithelium

of the human vas deferens, The Internet J Pathol 6(2)

Chen M, Gatalica Z, Wang B (2007) Cartilaginous and osseous metaplasia

in the aortic valve. The Internet J Cardiol 4(2).

Santos EE, Sarma DP, Chen M, Wang B (2007) Metatypical basal cell

carcinoma of the nose. The Internet J Dermatol 5(2).

Chen M, Sarma DP (2007) Intramuscular angioma of the frontalis muscle.

The Internet J Dermatol 5(2).

Chen M, Sarma DP (2007) Wooden splinter dermatitis. The Internet J

Dermatol 5(2).

Chen M, Sarma DP (2007) Multiple dermatofibromas in an adult female.

The Internet J Dermatol 5(1).

Meeting Abstracts:

M. Chen, C Snyder, L Hatcher, HT Lynch, P Watson, Z Gatalica (2009)

Barrett's esophagus in the patients with familial adenomatous

polyposis. USCAP 2009 Annual Meeting. Boston, MA.

G. Gupta, M. Li, Y. Sun, M. Chen, M. Gold, M. Simard, T. C. Chai (2007)

Increased efficacy of carbachol in inducing increases in intracellular

calcium ([Ca2+]i) and outward potassium currents (Io) in overactive

bladder (OAB) and interstitial cystitis (IC) human bladder urothelial

cells (BUC). Society for Urodynamics & Female Urology 2007 Annual

Meeting. San Diego, CA.

A. M. Bailey, A. J. Kallarackal, M. Chen, J. M. Simard (2006) Apamin

significantly improves spatial cognition in a mouse model of

Neurofibromatosis 1. Society for Neuroscience 2006 Annual Meeting.

Atlanta, GA.

M. R. Holton, P. S. Van Zijl, M. Chen, Y. Sun., J. M. Simard, T. C.

Chai (2005) Effect of muscarinic agonists on outward current in bladder

urothelial cells. Mid-Atlantic Section of the American Urological

Association 63rd Annual Meeting. Phoenix, AZ.

M. Chen, A. Kallarackal, Z. Li, N. Dugger, P. Hoffman, J. M. Simard

(2005) Small conductance calcium activated potassium (SK) channels in

neurofibromatosis-1 mouse brains. Society for Neuroscience 2005 Annual

Meeting. Washington, DC.

T. C. Chai, M. Chen, M. Holton, Y. Sun, T. Lehrfeld, J. Wynes, J. M.

Simard (2005) Carbachol induces increased outward potassium current in

human bladder urothelial cells. Society for Neuroscience 2005 Annual

Meeting. Washington, DC.

J. M. Simard, M. Chen, V. Gerzanich, K. Tarasov (2005) SUR1 - A novel

therapeutic target in

ischemia. The American Academy of Neurological Surgery Annual

Meeting, Half Moon Bay,

CA.

Z. Geng, M. Chen, J. M. Simard (2005) Activated matrix

metalloproteinase-2 and -9 expression in rat after focal cerebral

stroke. Society for Neuroscience 2005 Annual Meeting. Washington, DC.

P. S. Van Zijl, Y. Sun, M. Chen, J. M. Simard, T. C. Chai (2005) The

effect of epidermal growth factor (EGF) on inward potassium rectifying

currents in bladder urothelial cells. American Urological Association

100th Annual Meeting. San Antonio, TX.

M. R. Holton, P. S. Van Zijl, Y. Sun., M. Chen, J. M. Simard, T. C.

Chai (2005) The effect of Carbachol on Kir2.1 conductance in bladder

urothelial cells. American Urological Association 100th Annual Meeting.

San Antonio, TX.

B. H. Lowentritt, Y. Sun, M. Chen, J. M. Simard, T. C. Chai (2004)

Altered membrane ion channel properties in human bladder urothelial

cells from interstitial cystitis patients: insights into basic

urothelial cell function. American Urological Association 99th Annual

Meeting. San Francisco, CA

J. M. Simard, M. Chen (2003) Regulation by Sulfonylurea receptor type 1

of a non-selective cation channel involved in cytotoxic edema of

reactive astrocytes. Perioperative Neuroprotection Symposium 2003.

Annapolis, MD.

K.V. Rama Rao, M. Chen, J. M. Simard, M. D. Norenberg (2002) Increased

expression of aquaporin 4 in ammonia treated cultured astrocytes.

Society for Neuroscience 2002 Annual Meeting. Orlando, FL.

D. Kim, M. Chen, J. M. Simard. (2002) Treatment of stroke animal model

by sulfonylurea compounds. University of Maryland Medical Center Summer

Research Forum 2002. Baltimore, MD

G. Zhao, M. Chen, J. M. Simard. (2002) Estrogen regulation of a Ca2+-

activated Cl- channel in type R2 astrocytes. University of Maryland

Medical Center Summer Research Forum 2002. Baltimore, MD.

M. Tabatabai, M. Chen, J. M. Simard. (2001) Effects of 17-beta-

estradiol on expression of aquaporin-1 in reactive astrocytes from

adult rat brains. University of Maryland Medical Center Summer Research

Forum 2001. Baltimore, MD.

M. Chen, A. Tabatabai, J. M. Simard (2001) Inhibition of aquaporin-1

expression by 17-beta-estradiol in reactive astrocytes from adult rat

brain. Society for Neuroscience 2001 Annual Meeting. San Diego, CA.

M. Chen & J. M. Simard (2000) A calcium-activated nonspecific cation

channel in reactive astrocytes from adult rat brain. Society for

Neuroscience 2000 Annual Meeting. New Orleans, LA.

D. L. Jones & M. Chen (1999) Developmental changes in gap junctions in

normal and myopathic hamster hearts. Canadian Society of Physiology

31st Annual Winter Meeting. Marble Mountain, Newfoundland, Canada.

M. Chen & D. L. Jones (1998) Alteration in the distribution pattern of

gap junctions in ventricular myocardium from normal and cardiomyopathic

Syrian hamsters. Canadian Cardiology Society 1998 Annual Meeting,

Ottawa, Ontario, Canada.

D. L. Jones, M. Chen, N. Narayanan (1998) Structural and functional

alterations in heart failure: arrhythmias mechanisms in myopathic

Syrian hamsters. Canadian Society of Physiology 30th Annual Winter

Meeting. Kimberley, British Columbia, Canada.

M. Chen, H. Chen, L. Li, J. Wang. (1995) Morphometric studies on renal

biopsy tissues from patients of epidemic hemorrhagic fever. Chinese

Society Nephrology 1995 Annual Meeting. Nanjing, China.

MEMBERSHIPS:

American Medical Association (242********)

American Society for Clinical Pathology (ASCP 4183708)

United States Canadian Academy of Pathology (USCAP 21543)

College of American Pathologists (1134203)

Nebraska Association of Pathologists (NAP 901702)

PROFESSIONAL ORGANIZATIONS:

American Society for Investigative Pathology

American Society for Neuroscience

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