Kai Yu Jen

*** **** ******, *** ***

Indianapolis IN 46202

phone: 617-***-**** e-mail: abllgs@r.postjobfree.com

HIGHLIGHTs of qualifications

. Ph.D. in Pathology focusing on oncology research.

. Nine years of medical and scientific writing (basic and clinical

research).

. Nine years of peer-reviewed presentation and publication experience.

. Areas of Expertise: oncology, asthma and allergy, autoimmune diseases

and neuroscience.

. Grant writing and Research project management.

. Experience with IRB submission process and IACUC animal protocol

design and implementation.

PROFESSIONAL EXPERIENCE

Eli Lilly and Company

Associate Consultant, Scientific Communications

(Senior Medical Writer, Neuroscience therapeutic area)

Jun 2009-current

. Plan, write, edit and review the publication of key clinical

scientific data through peer-review journals and work with teams to

ensure development of documents, abstracts and manuscripts.

. Project-manage and ensure quality of manuscripts, posters, slide kits

and abstracts.

. Present posters at national and global scientific conferences.

. Drive scientific disclosure strategy and planning process.

. Independently complete core functional area projects while supporting

other projects from cross-functional teams.

. Prepare clinical study reports for regulatory submission

. Write, review and edit documents for regulatory submission.

Natural Standard (Integrative Medicine Website)

Research Collaborator and Scientific/Medical Writer

Oct 2008- Jun 2009

. Collated scientific data and expert opinions about topics in

integrative medicine.

. Developed and wrote monographs about alternative medicine.

University of California, San Diego, School of Medicine

Jan 2005- Jun 2009

Research Scientist

. Planned, wrote and reviewed research grants for NIH and scientific

papers for peer -reviewed journals in respiratory diseases, allergy

and immunology areas.

. Planning, writing and publication of 4 original research papers and 2

review scientific papers in peer-review journals focusing on allergic

diseases and asthma research.

. Prepared, published and presented 14 abstracts in global scientific

meeting including American Thoracic Society and Experimental Biology.

. Designed and implemented IACUC animal research protocols.

. Clinical Research experience: Evaluation of the Efficacy of Albuterol

vs Levalbuterol in patients with mild and severe asthma (2007-2008).

- Responsible for IRB submission and design of research protocols;

performed experiments and analyzed clinical data.

- Basic Knowledge of Biostatistics.

. Planned and Managed start-up of molecular biology laboratory.

. Characterized an antibody (anti-CD45RB) and a protein (Surfactant-D)

applicable in asthma therapy.

. Determined the mechanism of how anti-CD45RB and Surfactant D regulates

T cell immune function in a murine model of pulmonary allergic

inflammation.

Hollis Eden Pharmaceuticals

May 2008- Jun 2009

Research Scientist

. Designed and implemented projects for Steroid Hormone DHEA therapeutic

drug discovery program for autoimmune and allergic diseases.

. Responsible for the analysis of patient's blood samples from clinical

trials of autoimmune diseases.

. Developed and implemented Immunohistochemistry assays.

Harvard Medical School

Nov 2004- Dec 2005

Postdoctoral Research Scientist

. Targeted molecules in signaling pathways triggered by Epstein-Barr

virus encoded oncoprotein Latent Membrane Protein 1 (LMP1) expressed

in lymphomas.

. Planning, writing and publication of original research paper with

focus on oncology research (mechanism of lymphoma development).

Niigata University Graduate School of Medical and Dental Sciences

Oct 2000- Oct 2004

Graduate Research Assistant/Medical Writer

. Planning, writing and publication of 5 original research papers and 4

clinical case-reports in peer-review journals focusing on oncology

research related to oral and salivary gland cancers.

. Prepared and presented 15 abstracts and posters for global scientific

conferences.

. Characterized tumorigenic properties of Epstein-Barr virus encoded

LMP1 in malignant epithelial tumors.

Teaching Assistant- Pathology and Oral Pathology, Niigata University

Graduate School of Medical and Dental Sciences, 2000-2004.

Oral Surgeon- Heliopolis Hospital- Clinical Dental Service for HIV

positive, Oral Cancer and Handicapped patients, 1999-2000.

. Design and implement Inform Consent Forms for Dental Treatment.

TECHNICAL SKILLS

. Computer Skills: Microsoft Word, Excel, Power Point, Adobe Acrobat,

Adobe illustrator, Datavision, Photoshop, Endnote.

. Language: English (Fluent), Mandarin (native), Portuguese (native) and

Japanese (skilled).

Education

. Regulatory Affairs for the Biomedical Industry- Professional

Certificate Program from UCSD Extension School (2007-2009).

. Ph.D. in Pathology, Niigata University Graduate School of Medical and

Dental Sciences, Niigata, Japan (2000- Sep 2004).

. D.D.S., UNESP (Sao Paulo State University)-School of Dentistry- Brazil

(1995- 1998).

Honors and Awards

. Recipient of the Monbusho Scholarship from the Ministry of Education,

Japan (2000-2004).

. Travel award supported by the James W. McLaughlin endowment fund of

the University of Texas Medical Branch at Galveston and the National

Institute of Dental and Craniofacial Research, National Institutes of

Health, Bethesda, Maryland. (Feb, 2003).

Professional Affiliations

. American Medical Writers Association (AMWA).

. American Thoracic Society

community service

. Indy Reads Tutor for English as a Second Language- 2009-present.

Selected publications

1. Kryzhanovskaya LA, Xu W, Millen B, Acharya N, Jen KY, Osuntokun O.

Comparison of Long-term Weight Gain and Metabolic Changes between

Adolescents and Adults Treated with Olanzapine. J Child Adolescent

Pharm. In submission.

2. Camirand G, Wang Y, Wan YY, Jen KY, Guz G, Deng S, Farber DL, Perkins

DL, Finn PW, Lakkis FG, Shlomchik D, Flavell R, Rothstein DM. CD45

Ligation Induces Foxp3+ Tregs Through de novo Conversion and

Augmentation of Homeostatic Proliferation. Nature Immunol, (under

review).

3. Jen KY, Lin KW, Suarez CJ, Crouch E, Perkins D and Finn PW. Surfactant

D suppression of allergic inflammation is dependent on T cell

modulation through CTLA4. J Immunology. (accepted-scheduled for june

issue).

4. Nakajima T, Suarez CJ, Lin KW, Jen KY, Wittine LM, Makani S, Finn PW.

Acute Lung Injury: Early and Late Inflammatory Pathways. J Immunology.

(accepted-scheduled for june issue).

5. Makani SS, Jen KY and Finn PW. New Costimulatory Families: Signaling

Lymphocytic Activation Molecule in Adaptive Allergic Responses. Curr

Mol Med. 8: 359-364, 2008.

6. Ferrada MA, Gordon EL, Jen KY, He HZ, Lu X, Barone LM, Amirifeli S,

Perkins DL and Finn PW. R)-albuterol decreases immune responses: role

of activated T cells. Resp Res. 9:3, 2008.

7. Jen KY, Campo M, He H, Velasco G, Rothstein DM, Perkins DL, Finn PW.

CD45 RB ligation inhibits allergic pulmonary inflammation by inducing

CTLA-4 transcription. J Immunol. 179: 4212-4218, 2007.

8. Jen KY, Jain VV, Makani SS and Finn PW. Immunomodulation of allergic

responses by targeting costimulatory molecules. Curr Opin Allergy Clin

Immunol. 6: 489-94, 2006

9. Song YJ, Jen KY, Soni V, Kieff E and Cahir-Macfarland E. IL-1 receptor-

associated kinase 1 is critical for latent membrane protein 1-induced

p65/RelA serine 536 phosphorylation and NF?B activation. PNAS, 103:

2689-2694, 2006.

10. Jen KY, Higuchi M, Cheng J, Li J, Wu LY, Li YF, Li HL, Chen ZL,

Gurtsevitch V, Fujii M and Saku T. Nucleotide sequences and functions

of the Epstein-Barr virus latent membrane protein 1 genes isolated

from salivary gland lymphoepithelial carcinomas. Virus Genes 30:223-

35, 2005.

11. Jen KY, Cheng J, Takagi R, Hayashi T, Saku T. Central Hemangioma of

Maxilla: Report of a case with exophytic growth. Oral Oncology EXTRA

40: 88-90, 2004.

12. Jen KY, Cheng J, Li J, Wu LY, Li YF, Yu SF, Li HL, Chen ZL,

Gurtsevitch V and Saku T. Mutational events in LMP1 gene of Epstein-

Barr virus in salivary gland lymphoepithelial carcinomas. Int. J.

Cancer 105: 654-660, 2003.

13. Saku T, Cheng J, Jen KY, Tokunaga M, Liu AR, Zhang WG, Wu LY, Lu Y,

Zhou ZY, Li YF, Li RY, Ouyang J, Yang LJ, Yu SF, Lou TC, Wang SZ, Lin

DS, Rao HL, Lin HL, Sderk P, Chen ZL, Chen ZL, Cai CH, Kim HJ and Hong

SP. Epstein- Barr virus infected lymphoepithelial carcinomas of the

salivary gland in the Russia-Asian area: a clinicopathologic study of

160 cases. Arch. Pathol. 65: 35-39, 2003.

14. Metwaly H, Cheng J, Ida H, Ohshiro K, Jen KY and Saku T. Endothelial

Participation in formation of epimyoepithelial islands in benign

lymphoepithelial lesion. Virchows Arch. 443:17-27, 2003.

15. Jen KY, Cheng J, Maruyama S, Hayashi T, Suzuki I, Shingaki S and Saku

T. Mucoepidermoid Carcinoma in children: Report of a case and review

of literature. Oral Med Pathol, 7:27-31, 2002.

16. Homem MGN, Deboni MCZ and Jen KY. Squamous Cell Carcinoma of the

Maxilla, A Clinical Case Report. JBC, 20: 83-85, 2000.

Publication of abstracts in scientific journals

1. Alleva D, Nicoletti F, Mangano K, Tucker C, Azeem N, Kosiewicz M, Hein

N, Ticsay R, Jen KY, McNeeley P, Wang T, White S, Reading C, Frincke

J and Auci D. Efficacy of a Novel Synthetic Steroid, TRIOLEX (17?-

ethynyl-5-androsten-3?, 7?, 17?-triol), in Spontaneous Autoimmune

Diabetes in the Non-Obese Diabetic (NOD) Mouse. Clin Immunol, 131 (1):

S75, 2009.

2. Jen KY, Lin KW, Nakajima T, Suarez CJ, Perkins DL, Finn PW. Nicotine

Modulates Adaptive Immune Responses. American Journal of Respiratory

and Critical Care Medicine, 179: A2583, 2009.

3. Nakajima T, Suarez CJ, Lin KW, Jen KY, Wittine LM, Makani S, Finn PW.

Acute Lung Injury: Early and Late Inflammatory Pathways. American

Journal of Respiratory and Critical Care Medicine, 179: A3884, 2009.

4. Suarez CJ, Nakajima T, Jen KY, Lin KW, Makani S, Finn PW. Potential

Role of Adaptive Immune Cells in Acute Lung Injury. American Journal

of Respiratory and Critical Care Medicine, 179: A5674, 2009.

5. Wittine LM, Jen KY, Parker N, Finn PW. Toll-Like Receptor Agonists

Modify Cytokine Production in T Cells. American Journal of Respiratory

and Critical Care Medicine, 179: A5691, 2009.

6. Lin KW, Jen KY, Suarez CJ, He H, Crouch E, Perkins D and Finn PW.

Surfactant D Decreases Allergic Inflammation through Regulation of T

Cells. American Journal of Respiratory and Critical Care Medicine,

179: A6273, 2009.

7. Jen KY, He H, Mickelson A, Suarez CJ, Crouch E, Perkins DL, Finn PW.

Effects of surfactant protein D in the modulation of T cell

activation. Faseb J. 22: 672.57, 2008.

8. Suarez CJ, Jen KY, He H, Mickelson A, Perkins DL, Crouch E, Finn PW.

Surfactant Protein D Modifies T cell Activation. American Journal of

Respiratory and Critical Care Medicine, 177: A88, 2008.

9. Makani SS, Jen KY, He H, Finn PW. TLR4 Modulation of Immune Responses

in vivo and in vitro. American Journal of Respiratory and Critical

Care Medicine, 177: A103, 2008.

10. He H, Mickelson A, Jen KY, Suarez CJ, Perkins DL, Spragg R, Crouch E,

Finn PW. T Cell Activation: Effects of SP-A and SP-D. American Journal

of Respiratory and Critical Care Medicine, 177: A346, 2008.

11. Parker NJ, Suarez CJ, Jen KY, He H, Finn PW. TLR2 Signaling Induces

Regulatory T cell Markers in the Absence of TCR Stimulation. American

Journal of Respiratory and Critical Care Medicine, 177: A816, 2008.

12. Jen KY, He H, Mickelson A, Suarez CJ, Crouch E, Perkins DL, Finn PW.

Effects of surfactant protein D in the modulation of T cell

activation. Faseb J. 22: 672.57, 2008

13. Jen KY, Campo M, He H, Perkins D and Finn PW. CD45RB modulate allergic

inflammatory responses in vivo and in vitro. American Journal of

Respiratory and Critical Care Medicine, 175: A255, 2007.

14. Makani SS, Jen KY, He H, Perkins DL and Finn PW. TLR2 modulates

adaptive immune response in vitro. American Journal of Respiratory and

Critical Care Medicine, 175: A181, 2007.

15. Gordon E, Jen KY, Finn PW. Differential effects of R and S- albuterol

in T lymphocytes. American Journal of Respiratory and Critical Care

Medicine, 175: A315, 2007.

16. Cheng J, Jen KY, Zhou X, Tian Z, Maruyama S, Li Jiang, Saku T. Primary

culture of Epstein Barr virus related lymphoepithelial carcinoma cells

of salivary gland. The Korean Journal of Oral and Maxillofacial

Pathology, 29: P29, 2005.

17. Jen KY, Higuchi M, Cheng J, Fujii M, Saku T. LMP1 gene of EBV isolated

from salivary lymphoepithelial carcinomas inhibits cell growth and

activates NF(-B pathway. Cancer Science supplement, 95: 72, 2004

18. Jen KY, Cheng J, Saku T. Sequence analysis of the promoter region of

the EBV LMP1 gene isolated from salivary gland lymphoepithelial

carcinomas. Cancer Science supplement, 94: 53, 2003.

19. Jen KY, Cheng J, Saku T. The myxoid neoplastic stroma in salivary

gland lymphoepithelial carcinomas may represent a barrier against T

lymphocytes infiltration. Jpn J Oral Biol, 45: 165, 2003.

20. Jen KY, Cheng J, Li J, Wu LY, Li YF, Yu SF, Lin HL, Chen ZL,

Gurtsevitch V, Saku T. Mutational events in LMP1 gene of Epstein-Barr

virus in salivary gland lymphoepithelial carcinomas. J Oral Pathol &

Med, 31: 296, 2002.

21. Jen KY, Cheng J, Saku T. Possible molecular mechanisms for EBV

infection in salivary gland lymphoepithelial carcinomas. Jpn J Oral

Biol, 44: 133, 2002.

22. Wei JX, Cheng J, Jen KY, Saku T. Overexpression of extracellular

matrix molecules in metastatic adenoid cystic carcinoma cells of

salivary gland origin. Jpn J Oral Biol, 44: 165, 2002.

23. Jen KY, Cheng J, Maruyama S, Hayashi T, Suzuki I, Shingaki S, Saku T.

Mucoepidermoid Carcinoma in Children: Report of a case and review of

literature. Oral Medicine & Pathology, 6:111, 2001.

Publication of abstracts in congress scientific annals

1. Jen KY, Tohen M, Wang W. Risk Factors as Mediators and Moderators in

Predicting Relapse to Any Type of Mood Episode in a Bipolar

Maintenance Study. International Review of Bipolar Disorders (IRBD),

Budapest, Hungary. 12-14 May 2010.

2. Syafriadi M, Cheng J, Suzuki M, Jen KY, Saku T. Histopathological

Criteria for carcinoma in-situ of the oral mucosa confirmed by p53

mutations. In Proceedings of the Japanese Society of Pathology, 93:

339, 2004.

3. Cheng J, Jen KY, Maruyama S, Yamazaki M, Zhou ST, Ten Z, Saku T.

Molecular Pathology characterization of the salivary gland

lymphoepithelial carcinoma cell line infected by EBV. In Proceedings

of the Japanese Society of Pathology, 93: 367, 2004.

4. Jen KY, Cheng J, Saku T. Characterization for ECM molecules of two

distinct types of the neoplastic stroma in oral squamous cell

carcinoma. In Proceedings of the Japanese Society of Pathology, 92:

361, 2003

5. Jen KY, Cheng J, Suzuki M, Niimi K, Saito C, Kobayashi F, Hayashi T

and Saku T. Tumor of the palate. In 14th annual meeting of the

Japanese society for oral pathology. S-17, 2003.

6. Jen KY, Cheng J, Saku T. Sequence Variation of the LMP1 Gene of EBV in

Salivary Gland Lymphoepithelial Carcinomas from different regions of

China and Russia. In. The Second Annual Mclaughlin Symposium in

Infection and Immunity, Galveston, Tx, USA, 2003.

7. Jen KY, Cheng J, Saku T. Oral Papillary Endothelial Hyperplasia: an

immunohistochemical demonstration of its pathogenesis. In. Proceedings

of the Japanese Society of Pathology, Tokyo, 2002.

8. Jen KY, Cheng J, Nishihara H, Takagi R, Tanaka R, Hayashi T and Saku

T. Tumor of Maxilla. In. The 13th annual meeting of the Japanese

Society for Oral Pathology, S-1, 2002.

9. Metwaly H, Cheng J, Ida H, Ohshiro W, Jen KY, Saku T. Endothelial

participation in formation of epimyopithelial islands in benign

lymphoepithelial lesion. In. Proceedings of the Japanese Society of

Pathology, Tokyo, 2002.

Publication of articles for Natural Standard (integrative medicine)

website:

1. Natural Standard Professional Database and Handbooks: Professional

Monograph about Durian (Jan, 2009).

2. Natural Standard Professional Database and Handbooks: Professional

Monograph about Trumpet Tree (Jan, 2009).

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