Project Assistant
Resume:
ANJA S. H. MARINI
**** ****** **** ****, ***. ***
Madison, WI 53704-8654
abldzv@r.postjobfree.com
SUMMARY
Senior Research Scientist with 7+ years experience in the pharmaceutical
industry developing and performing small, medium and large multi-step
organic synthesis, providing support from discovery to development track.
Experienced in the management and coordination of synthesis project teams
consisting of up to 4 scientists during scale-up campaigns. Skilled in
analytical techniques such as HPLC, LC/MS, GC/MS and NMR. Excellent
communication and presentation skills. Fluent in German.
EDUCATION
Ph.D., Chemistry, Texas A&M University, College Station, TX
Dissertation Title: A Unified Strategy Toward the Biogenetically Related
Oroidin Derived Bisguanidine Marine Alkaloids: Palau'amines,
Styloguanidines and Axinellamines.
Advisor: Professor Daniel Romo.
B.A., Chemistry, Florida International University, Miami, FL
EXPERIENCE
Pfizer (formerly Wyeth Research), Princeton, NJ and Pearl River, NY
2002-2010
Sr. Research Scientist II
. Executed small, medium and large-scale synthesis of pharmacological
lead compounds for high dose pharmacokinetic (PK) and maximum tolerated
dose (MTD) studies for oncology, neuroscience and inflammation project
teams.
. Ensured timely delivery and acceptable impurity profile via early
assessment of impurity profile of intermediates.
. Performed process research chemistry by developing and optimizing
synthetic sequences, conducting salt screening, and evaluating
crystallinity. Assessed compound purity and integrity via NMR, HPLC,
LC/MS and GC/MS.
. Managed and coordinated synthesis project teams of up to 4 scientists
during scale-up campaigns.
. Compiled detailed reports upon project completion and served as Discovery
Synthetic Chemistry representative in project transfer meetings
. Technical liaison to the GVK Bio alliance management team developing,
monitoring, cataloging, and tracking synthesis requests for advanced
pharmacological lead compounds, intermediates, and pharmacological
reference standards in support of Exploratory and Discovery project
teams.
. Provided managerial support in the Wyeth-Biotica partnership as Discovery
Synthetic Chemistry team leader, updating the project team on the
progress of synthesis requests during bi-weekly Wyeth-Biotica
teleconference team meetings and quarterly joint research committee
meetings. Proposed synthetic schemes for intermediates requested for the
preparation of rapamycin analogs.
. Guided and mentored a junior level associate during scale-up campaigns.
. Maintained and managed a ChemFinder database entering and tracking
synthesis requests for the Discovery Synthetic Chemistry team.
. Coordinated acquisition and installation of the Yamazen WPrep preparative
MPLC system for the Pearl River Discovery Synthetic Chemistry group.
Ensured proper instrument operation and maintenance and functioned as
primary training contact.
Sr. Research Scientist I
. Devised alternative synthetic schemes to lead compounds, balancing the
timely delivery of high quality batches with tight time constraints.
Enabled an expansion of SAR studies via implementation of a modified
synthetic route.
. Functioned as a lead Discovery Synthetic Chemist for a neuroscience
project team, which culminated the preparation of 810 g of a pre-
development candidate via a 7 step synthetic sequence over 3 months.
Conducted parallel salt screen to identify crystal form with acceptable
purity and physical-chemical profile, which was utilized in the initial
dosing studies.
. Served as Discovery Synthetic Chemistry representative on project team
and pre-development team meetings.
. Coordinated acquisition and installation of an analytical Agilent 1100
HPLC for the Princeton Discovery Synthetic Chemistry group. Performed
routine instrument maintenance and functioned as main contact to aid in
the training of colleagues.
Department of Chemistry, Texas A&M University, College Station, TX
1997-2002
Research Assistant. Development of a concise asymmetric synthetic strategy
toward a class of related bisguanidine marine alkaloids including the
axinellamines, palau'amines, and styloguanidines.
Teaching Assistant. Instructor in undergraduate freshman chemistry and
organic chemistry laboratories. Development, administration and grading of
quizzes.
Department of Chemistry, Florida International University, Miami, FL
1995-1997
Research Assistant. Synthesis and characterization of ferrocenecarbamates:
electrochemically ionizable derivatives of simple alcohols, sterols, and
phenols for ESI-MS analysis.
Teaching Assistant. Instructor in undergraduate organic chemistry
laboratories. Development, administration and grading of quizzes.
TRAINING & DEVELOPMENT
Team Leader Training Program, Wyeth Research, Cambridge, MA, 2008
Women as Leaders in Discovery Program, Ros Taylor Ltd, Wyeth Research 2005-
2007
Diversity Leadership Development Program, Nancy Sherman, Wyeth Research,
2006-2007
HONORS AND AWARDS
Team of the Year Award, Wyeth Research, January 2007
Above and Beyond Award, Wyeth Research, December 2005
Above and Beyond Award, Wyeth Research, December 2004
Pharmaceutical Industry-University Cooperative Chemistry Program (PIUCCP)
Award,
Department of Chemistry, Texas A&M University, October 2001 (award given
for outstanding oral presentation)
Chemistry/Biology Interface (CBI) Training Program Travel Award, Department
of Chemistry, Texas A&M University, Spring 2001
Pharmaceutical Industry-University Cooperative Chemistry Program (PIUCCP)
Award, Department of Chemistry, Texas A&M University, April 2000 (award
given for outstanding oral presentation)
A.E. Martell Travel Award, Department of Chemistry, Texas A&M University,
Fall 1999
NIH Chemistry/Biology Interface (CBI) Training Grant, Department of
Chemistry, Texas A&M University, September 1998-September 2000
Dean's Graduate Scholar, Department of Chemistry, Texas A&M University,
1997-1998
Summa Cum Laude, Florida International University, B.A., 1995
PUBLICATIONS
"An improved method for the preparation of substituted N-
(aminocyclohexyl)benzo-thiophene-2-carboxamides" Krishnan, Lalitha; Blum,
David M.; Dilley, Anja Susanne; Pan, Sherry; Potoski, John R.; Shah, Uresh
S.; Sharma, Archana; Strong, Henry Lee; Wu, Yanzhong; Zhang, Mei-Yi. PCT
Int. Appl. (2007), WO 200-***-**** A2 20070809 CAN 147:257635 AN
2007:873145.
"Planned and unplanned halogenations in route to selected oroidin
alkaloids." Wang, Shaohui; Dilley, A.S.; Poullennec, K.G.; Romo, D.
Tetrahedron 2006, 62, 7155-7161.
"A unified synthetic strategy toward oroidin-derived alkaloids premised on
a biosynthetic proposal." Dransfield, P.J.; Dilley, A.S.; Wang, S.; Romo,
D. Tetrahedron 2006, 62, 5223-5247.
"Highly regioselective Diels-Alder reactions toward oroidin alkaloids: use
of a tosylvinyl moiety as a nitrogen masking group with adjustable
electronics. " Dransfield, P.J.; Wang, S.; Dilley, A.; Romo, D. Organic
Letters 2005, 7, 1679-1682.
"Enantioselective Strategy to the Spirocyclic Core of Palau'amine and
Related Bisguanidine Marine Alkaloids." Dilley A.S. and Romo D. Org. Lett.
2001, 3, 1535-1538.
"Derivatization for Electrospray Ionization Mass Spectrometry: 3
Electrochemically Ionizable Derivatives." Van Berkel, G.J.; Quirke,
J.M.E.; Tigani, R.A.; Dilley, A.S. and Covey, T.R. Anal. Chem. 1998, 70,
1544-1554.
SELECTED PRESENTATIONS
16th Annual Chemical and Screening Sciences Symposium (CSSS), September 24,
2008, Pearl River, New York. "Discovery Synthetic Chemistry: Medium-Scale
Synthesis at the Discovery-Development Interface". (poster presentation)
14th Annual Chemical and Screening Sciences Symposium (CSSS), September 19,
2006, Princeton, New Jersey. "Immunophilin Ligands: Process Developments
in the Synthesis of WAY-265920 and Evaluation of Physical-Chemical
Properties". (oral presentation)
57th American Chemical Society Southwest Regional Meeting, October 17-20,
2001, San Antonio, Texas. "Studies Toward the Asymmetric Synthesis of
Oroidin-derived, Bisguanidine Marine Alkaloids." (poster presentation)
Pharmaceutical Industry-University Cooperative Chemistry Program (PIUCCP)
Symposium, October 1-4, 2001, Texas A&M University, College Station,
Texas. "Studies Toward the Asymmetric Synthesis of Oroidin-derived Marine
Alkaloids." (oral presentation)
221st American Chemical Society National Meeting, April 1-5, 2001, San
Diego, California. "Synthetic Studies Toward Palau'amine." (oral
presentation)
Pharmaceutical Industry-University Cooperative Chemistry Program (PIUCCP)
Symposium, April 12-13, 2000, Texas A&M University, College Station,
Texas. "Synthetic Studies toward the Common Tricyclic Core of the
Palau'amines and Styloguanidines." (oral presentation)
219th American Chemical Society National Meeting, March 26-30, 2000, San
Francisco, California. "Synthetic Studies toward the Common Tricyclic
Core of the Palau'amines and Styloguanidines." (poster presentation)
AFFILIATIONS
American Chemical Society
1998-present
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