Project Manager Management
Resume:
Massoud Daheshia, Ph.D.
Home address:
Cedar Park, TX 78613
Email: abl89o@r.postjobfree.com
Work address:
Zimmer Inc.
Austin, TX 78729
EDUCATION
Postdoctoral Fellow, 1998-2001, Harvard Medical School
Ph.D. (Molecular Immunology) 1997, University of Tennessee
D.E.A. (Molecular Biology) 1990, Universit de Pierre et Marie Curie (PVI),
Paris, France
M.A. (Biochemistry) 1989, Universit de Jussieu (PVII), Paris, France
B.A. (Biochemistry) 1987, Universit de Jussieu (PVII), Paris, France
EMPLOYMENT
2007 - Present, Project Manager/Senior Immunologist Zimmer Inc., Austin, TX
. Project manager Inflammatory & biologics portfolio
. Director of immunological and in vivo pharmacological studies in
support of R&D activities & oversight CRO activities and clinical
studies
. Research & Development Osteoarthritis & in vivo pharmacology :
immunogenecity, tissue rejection, anti bacterial and safety evaluation
of biologics, & drug/device combinations
. Due Diligence for inflammatory disorders & anti-arthritis strategies
. Product evaluation for drug-device combination with anti bacterial
properties and enhanced cell growth activities
. Present key new scientific information and relevant clinical
information to the management board
. Product evaluation & development cell therapy and scaffold-assisted
matrix
. Development of Chondrofix (allograft bone-cartilage) for management
of osteoarthritis
. Research & Development for Xeno-graft soft tissues (porcine, bovine
and equine)
. Due diligence, market analysis, and in-licensing of high molecular
weight Hyaluronic acid (HA) Gel 200 for intra-articular management
of osteoarthritis and pain
. Due diligence and evaluation of collagen scaffold ZCR Patch for
Tendon/ligament enhancement and its in-licensing
. Preparation of regulatory document (PMA and attending FDA panel
meetings
. Assessment of systemic and local biomarkers for local and systemic
inflammation and infection
. Review clinical trials protocols for pain and arthritis
. Product positioning, training and working closely with sales teams
DeNovoNT
. Management of technologists: mentoring, training, and timeline
. Educating Zimmer associates on Inflammation and infection through
internal seminars and presentations
. Developing relationship with key opinion leaders and medical community
. Training of associates in new biological techniques
2004 - 2007, Associate Scientist/Laboratory Director, Lovelace Respiratory
Research Inc. Albuquerque, NM
. Chief Immunologist, Project Manager for inflammatory and
infection disorders: viral & bacterial infection and pathogen
-exacerbation of lung infection
. In vivo pharmacologist for drugs and biologics screening in
monkeys, rats and mice
. Efficacy Immunogenecity and safety studies in baboons, sheep,
rabbits, rats and mice
. Preclinical studies, including PK/PD activities for safety
and efficacy of Syk Kinase inhibitor of viral & bacterial
exacerbation of COPD
. Advancement of Kinase inhibitor Syk to Clinical Trial for
asthma indication
. Management and training of PhDs and technologists in
therapeutic areas
. Contract Research Organization (CRO) activities with drug development
partner for Chronic inflammatory diseases
. Assessment of systemic and local biomarkers for pathogen- exacerbation
of lung inflammation following RSV infection
. Phenotyping of pulmonary epithelial cells from patients with ongoing
pulmonary inflammation
. Institutional Animal Care and Use Committee (IACUC) full member
. Pathogen-safety committee member ( BSL2, BSL3)
. Preparation of SOPs, Research Plans and performing internal audits
. Organization of monthly scientific round tables with external opinion
leaders in immunology
. Adjunct assistance professor in Department of Pathology and Department
of Pharmacology at University of NM
. Lectures on Microbiology and Immunology to first and second year
student nurses at Apollo Collage
. Training and Mentoring of fellow associates on Chronic and Infectious
Diseases
2001 - 2004, Principal Scientist, Aventis Pharmaceutical, Bridgewater, NJ
. Principal Immunologist, Project manager for inflammatory
disorders & team leader of in vivo pharmacology activities
. Define and Develop the five-year plan Goals and Objective of
Internal Medicine department
. Assistance in market positioning and five-year scientific
planning portfolio for strategic management of inflammation
. Development of Alvesco for management of lung inflammation
(Marketed in US in 2005)
. Safety and post market evaluation of Allegra (Marketed in US
in 1999)
. Management and training of Technologists and Post-Docs in new
biological techniques
. Collaborative activities with biotechnology organizations and
in-licensing of new drugs for management of pulmonary
infection and inflammation
. Training of Medical Science Liaison (MLS) and sales
associates for Alvesco
. Collaboration with Trudeau Institute for evaluation of
compounds suppressing pulmonary influenza infection
. Development of relationship with key opinion leaders of
inflammatory disorders
. Full member of pathogen infectious committee
. Institutional Animal Care and Use Committee (IACUC) full member
. Full member of new target identification and proof of concept
validation Committee
. Assistance in In-licensing of new class of
immunomodulators/immunosuppressor
. Research & Development for rheumatoid arthritis, pain and
asthma/allergy/rhinitis
. Advancement of immunomodulators to clinical trials for
infectious disease treatment
. Preclinical studies for Kinase inhibitors including PK/PD,
safety and efficacy studies
. Advancement of p38 kinase inhibitors to clinical trials for
arthritis treatment
. Adjunct assistance professor of immunology to teach medical
students at Rutgers university
. Community work for advancement of science: Community talks
regarding the scientific and ethical aspects of animal use in
science and medical research
1998 - 2001, Research Fellow, Harvard Medical School (Department of
Immunology), Boston, MA
. Evaluation of cell inhibitory receptors in the pathogenesis
of asthma/arthritis & bacteria/viral infection
. Collaboration with external pharmaceuticals organization for
evaluation of IL-13 inhibitors in suppression of pulmonary
inflammation
. Generation and evaluation of Knock-out (KO) and Transgenic
(Tg) mice for mast cell inhibitory receptor gp49
. Contract Research Activities (CRO) for evaluation of
humanized monoclonal antibodies for suppression of Salmonella
infection
. Evaluating the role of gp49 in viral LCMV and Salmonella
infection
. Generation and phenotyping of primary mast calls from
asthmatic patients
. Organizer of weekly Journal club at Brigham hospital
. Organizer of monthly Round Table for New Developments in
Management of Chronic Inflammatory Diseases
. Training of technologists and students in new biological and
immunological techniques
. Management of three technologists for their weekly
activities
. Lecture to second year medical students ( Boston University):
Molecular Basis of Diseases
. Editorial & peer-review l actives as external referee for
immunology journals
1994 - 1998, Research Assistant, Department of Immunology, University of
Tennessee, Knoxville, TN
. Characterization of Pathogenesis of herpes infection
. Vaccine development for systemic and mucosal herpes infection
using DNA, and viral vectors
. Ocular manipulation of HSV infection to suppress of herpetic
eye blindness
. Development of gene therapy, and cytokine delivery for
treatment of herpes and salmonella infection.
. The first Investigator to report the efficacy of cytokine DNA
technology for inflammatory disease management (cited in
Wikipedia)
. DNA vaccine development for management of exacerbation of
pulmonary infection by herpes infection
. Molecular cloning of T cell receptor (TCR) specific to
herpes.
. Contract Research Activities (CRO) for evaluation of new
adjuvant formulation for in vivo delivery of biologics
. Development of lipid mediators for mucosal vaccine delivery
. Training and mentoring of Technologists and student in
Molecular Biology techniques
. Teaching first year veterinarian students ( University of
Tennessee): The Mechanisms of Disease
1991, Research Visitor, Institu fur Molekurbiologec und Tumorforchumg,
Philipps
Universitat, Marburg, Germany
. Characterization of the steroid receptor-DNA binding: report
of an unusual steroid receptor responsive element on hepatic
Aspartate Aminotransferase.
1989 - 1994, Research Assistant, University of Marie Curie, INSERM, Unite
99, Hospital Henrie Mondor, Paris, France
. Research & Development : Hormonal Gene Regulation
. Molecular cloning of Aspartate Aminotransferase (AA) and its
nucleotide sequencing
. Investigating transcriptional gene regulation of AA by
steroids and glucagons, and gene suppression by insulin and
phorbol ester.
. Investigating effects of steroids on gene expression of
hepatic cells and identifying new glucocorticoid responsive
elements
. Development of a New Plasmid DNA Isolation Kit
. Submission of an experimental Grant to French Research &
Development Agency: Suppression of Asthma by ICAM fragments
genetically engineered
. Training of Technologist and students in Molecular and
cellular Biology
. Review activities for the journal of FASEB Letters
. Teaching Biological Science at Louis Pasteur High School,
Paris, France
PROFESSIONAL AFFILIATIONS AND HONORS
. Fellowship from Minister Of Recherche &Technologie, France, 1990-1994
(Ranked 2nd out of 51 applicants)
. Graduate research fellowship from NIH, 1994-1997
. Postdoctoral training fellowship from NIH, 1998-2001
. Science Alliance Graduate Award of Excellence (student of the year)
from the University of Tennessee, 1997
. Special annual award for milestone accomplishment from Aventis
Pharmaceutical for advancement of immunomodulator to clinical trial
for rhinitis, 2002
. Quarter award for scientific accomplishment from Aventis Pharmaceuticals,
7/2001, 10/2001, 4 /2002, 7/2002, 1/2003, 7/2003, 10/2003
. Annual award of excellence for evaluation and licensing of high molecular
weight hyaluronan from Zimmer Inc., 2009
. Invited contributor for the Journals of Current Opinion in
Microbiology, Current Medical Research Opinion, Clinical and Applied
Immunology Reviews, and International Journal of COPD.
. Forty three (43) invited seminars since 2000 ( list of presentations
available)
. Member, American Association of Science
. Member, American Association of Immunologists
. Member, American Association of Microbiologist
PUBLICATIONS
1. Aggerbeck, M., M. Garlatti, S. Feillux-Duche, C. Veyssier, M. Daheshia,
J. Hanoune and R. Barouki: Regulation of the Cytosolic Aspartate
Aminotransferase Housekeeping Gene Promotor by Glucocorticoids, cAMP,
and Insulin. Biochemistry 32: 9065-9072, 1993.
1. Garlatti, M., V. Tchesnokov, M. Daheshia, S. Feilleux-Duche, J. Hanoune,
M. Aggerbeck and R. Barouki: CCAAT/Enhancer-Binding Protein-Related
Proteins Bind to the Unusual Promotor of the Aspartate Aminotransferase
Housekeeping Gene. J. Biol. Chem. 268: 6567-6574, 1993.
2. Garlatti, M., M. Daheshia, E. Slater, J. Bouguet, J. Hanoune, M. Beato
and R. Barouki: A Functional Glucocorticoid-Responsive Unit Composed of
Two Overlapping Inactive Receptor-Binding Sites: Evidence for Formation
of a Receptor Tetramer. Mol. Cell. Biol. 12: 8007-8017, 1994.
3. Kanangat, S., P. Blair, R. Reddy, M. Daheshia, V. Godfrey, B. T. Rouse
and E. Wilkinson: Disease in the Scurfy (sf) Mouse is Associated with
Overexpression of Cytokine Genes. Eur. J. Immunol. 26: 161-165, 1996.
4. Daheshia, M., N. Kuklin, S. Kanangat, E. Manickan, and B. T. Rouse:
Suppression of Ongoing Ocular Inflammatory Disease by Topical
Administration of Plasmid DNA Encoding IL-10. J. Immunol. 159: 1945-
1952, 1997.
5. Kuklin, N., M. Daheshia, K. Karem, E. Manickan and B. T. Rouse:
Induction of Mucosal Immunity against Herpes Simplex Virus by Plasmid
DNA Immunization. J. Virol. 71: 3138-3145, 1997.
6. Chun, S., M. Daheshia, N. A. Kuklin and B. T. Rouse: Modulation of
Viral Immunoinflammatory Responses with Cytokine DNA Administered by
Different Routes. J. Virol. 72: 5545-5551, 1998.
7. Daheshia, M., L. T. Feldman and B. T. Rouse: Herpes Simplex Latency and
the Immune Response. Curr. Opin. Microbiol. 1: 430-435, 1998.
8. Daheshia, M., S. Kanangat and B. T. Rouse: Production of Key Molecules
by Ocular Neutrophils Early After Herpetic Infection of the Cornea.
Exp. Eye Res. 67: 619-624, 1998.
9. Daheshia, M., N. Kuklin, E. Manickan, S. Chun and B. T. Rouse: Immune
Induction and Modulation by Topical Ocular Administration of Plasmid DNA
Encoding Antigens and Cytokines. Vaccine 16: 1103-1110, 1998.
10. Gangappa, S., J. S. Babu, J. Thomas, M. Daheshia and B. T. Rouse:
Virus-Induced Immunoinflammatory Lesions in the Absence of Viral Antigen
Recognition. J. Immunol. 161: 4289-4300, 1998.
11. Kuklin, N. A., M. Daheshia, S. Chun and B. T. Rouse: Immunomodulation
by Mucosal Gene Transfer Using TGF-? DNA. J. Clin. Invest. 102: 438-
444, 1998.
12. Kuklin, N. A., M. Daheshia, S. Chun and B. T. Rouse: Role of Mucosal
Immunity in Herpes Simplex Virus Infection. J. Immunol. 160: 5998-6003,
1998.
13. Kuklin, N. A., M. Daheshia, P. C. Marconi, D. M. Krisky, R. J. Rouse,
J. C. Glorioso, E. Manican and B. T. Rouse: Modulation of Mucosal and
Systemic Immunity by Enteric Administration of Nonreplicating Herpes
Simplex Virus Expressing Cytokine. Virology 240: 245-253, 1998.
14. Manickan, E., M. Daheshia, N. Kuklin, S. Chun and B. T. Rouse:
Modulation of Virus-Induced Delayed-Type Hypersensitivity by Plasmid DNA
Encoding the Cytokine Interleukin-10. Immunology 94: 129-134, 1998.
15. Thomas, J., S. Gangappa, S. Chun, M. Daheshia and B. T. Rouse:
Immunopathogenesis of Herpetic Stromal Keratitis, a Blinding Disease of
Mankind. Central Eur. J. Immunol. 23: 72-83, 1998.
16. Chun, S., M. Daheshia, S. Lee, S. K. EO and B. T. Rouse: Distribution
Fate and Mechanism of Immune Modulation Following Mucosal Delivery of
Plasmid DNA Encoding IL-10. J. Immunol. 163: 2393-2402, 1999.
17. Chun, S., M. Daheshia, S. Lee and B. T. Rouse: Immune Modulation of IL-
10 Gene Transfer via Viral Vector and Plasmid DNA: Implication for Gene
Therapy. Cell. Immunol. 194: 194-204, 1999.
18. Daheshia, M., S. Deshpande, S. Chun, N. A. Kuklin and B. T. Rouse:
Resistance to Herpetic Stromal Keratitis in Immunized B-Cell-Deficient
Mice. Virology 257: 168-176, 1999.
19. Deshpande, S. P., M. Zheng, M. Daheshia and B. T. Rouse: Pathogenesis
of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesion in B-
Cell-Deficient Mice. J. Virol. 74: 3517-3524, 2000.
20. Daheshia, M., D. S. Friend, M. J. Grusby, K. F. Austen and H. R. Katz:
Increased Severity of Local and Systemic Anaphylactic Reactions in
gp49B1-Deficient Mice. J. Exp. Med. 194: 227-234, 2001.
21. Daser, A., M. Daheshia and G. T. De Sanctis: Genetics of Allergen-
Induced Asthma. J. Allergy Clin. Immunol. 108: 167-174, 2001.
22. De Sanctis, G. T., M. Daheshia and A. Daser: Genetics of Airway
Hyperresponsiveness. J. Allergy Clin. Immunol. 108: 11-20, 2001.
23. Daheshia, M., N. Tian, T. Connolly, A. Drawid, Q. Wu, J. G. Bienvenu,
J. Cavallo, R. Jupp, G. T. De Sanctis and A. Minnich: Molecular
Characterization of Antigen-Induced Lung Inflammation in a Murine Model
of Asthma. Ann. N. Y. Acad. Sci. 975: 148-159, 2002.
24. Tesfaigzi, Y., M. J. Fischer, M. Daheshia, F. H. Green, G. T. De
Sanctis and J. A. Wilder: Bax is Crucial for IFN-?-Induced Resolution
of Allergen-Induced Mucus Cell Metaplasia. J. Immunol. 169: 5919-5925,
2002.
25. Feldweg, A. M., D. S. Friend, J. S. Zhou, Y. Kanakoa, M. Daheshia, L.
Li, K. F. Austen and H. R. Katz: gp49B1 Suppresses Stem Cell Factor-
Induced Mast Cell Activation-Secretion and Attendant Inflammation In
Vivo. Eur. J. Immunol. 33: 2262-2268, 2003.
26. Gu, X., A. Laouar, J. Wan, M. Daheshia, J. Lieberman, W. M. Yokoyama,
H. R. Katz and N. Manjunath: The gp49B1 Inhibitory Receptor Regulates
the IFN-? Responses of T Cells and NK Cells. J. Immunol. 170: 4095-
4101, 2003.
27. Zhou, J. S., D. S. Friend, A. M. Feldweg, M. Daheshia, L. Li, K. F.
Austen and H. R. Katz: Prevention of Lipopolysaccharide-Induced
Microangiopathy by gp49B1: Evidence for an Important Role for gp49B1
Expression on Neutrophils. J. Exp. Med. 198: 1243-1251, 2003.
28. Daheshia, M.: Therapeutic Inhibition of Matrix Metalloproteinases for
the Treatment of Chronic Obstructive Pulmonary Disease (COPD). Curr.
Med. Res. Opin. 21(4): 587-594, 2005.
29. Daheshia, M. and Y. Tesfaigzi: The Role of Matrix Metalloproteinases
in Chronic Pulmonary Diseases: Relevance of the Airway Epithelium.
Curr. Resp. Med. Rev. 1(2): 165-170, 2005.
30. Daheshia, M: Pathogenesis of Chronic Obstructive Pulmonary Disease
(COPD). Clin. Appli. Immuno. Rev. 5:339-***-****
31. Daheshia, M. and J. Yao: The IL-1 ? signal transduction in the
pathogenesis of osteoarthritis. J.Rheum. 35: 2306-2312. 2008.
32. Daheshia, M. and J. Yao: The bone marrow lesion in osteoarthritis.
Rheumatol Int. 2010 Apr 3. [Epub ahead of print]
BOOK CHAPTERS
1. Kuklin, N. A., M. Daheshia and B. T. Rouse: Mucosal Immune Induction by
Naked DNA Administered Intranasally. In Proceedings of 9th
International Congress of Mucosal Immunology, 1997.
33. Rouse, B. T., M. Daheshia and D. S. Schmid: Herpes Simplex Virus and
the Immune Response: A Balance of Power. In Effects of Microbes in
Immune System (M. W. Cunningham and R. S. Fujinami, eds.), pp. 387-398,
Lippencott-Raven, Phildelphia, PA, 1999.
34. Daheshia, M. and Tesfaigzi, Y., "CD14," Encyclopedia of Respiratory
Medicine, edited by Geoffrey J Laurent and Steven D Shapiro, p.343,
Elsevier Ltd., 2006.
PATENTS
1. Jupp, R., P. Eynott, M. Weissensee, M. Daheshia and A. Minnich: Method
of Treating Th2-Type Inflammatory Diseases. USA V2004/0057 US PSP,
2004.
35. Minnich, A., M. Daheshia, S. Engle, H. Dressler and R. Jupp: HM74a as
a Molecular Target for Pulmonary Inflammatory Disease. USA V2004/0056,
2004.
36. Hai-Qing Xian, Jian Q. Yao, Hali Wang, Massoud Daheshia, and Hui Liu:
Scaffold Coated and/or Impregnated with at least One Bioactive Agent for
Tissue Repair and Other Medical Applications. U.S. A. No. 61/076,277
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