Mechanical Software

Robert W. Goulet, Ph.D.

** ********* **.

Labadie, MO 63055

636-***-**** (Home)

636-***-**** (Cell)

abl66s@r.postjobfree.com

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Summary

Insightful, deliberative Senior Principal Scientist with extensive

knowledge in developing scientific programs, cheminformatic and

computational chemistry tools used in the pharmaceutical industry, as well

as a strong bioengineering background. These tools have impacted both local

and global teams. Background includes developing several web-based tools.

Used commercial tools and integrated them within internal computational

environment. Am known for my ability to carefully indentify and weigh all

options before making decisions, able to easily adapt to new situations and

ensure project completion benefiting the organization and customer. Work

well within a team or individually, continuously strive to learn, apply,

teach and develop successful solutions using ingenious methods.

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Professional Experience

Pfizer, Inc., St Louis, MO 2007 to Present

Senior Principal Scientist

. Using experience from developing local patent analysis tools,

significantly contributed to the Global Patent Analysis Tools team

goal of developing and delivering several tools by the end of 2009

enabling scientists to more easily and quickly get a better

understanding of the IP space.

. As member of the Structural and Computational Chemistry group in PGRD

St Louis, developed innovative computational tools and procedures that

enabled researches to test and evaluate drug candidates ensuring only

the most desirable ones would be synthesized. Developed docking

protocols, QSAR models, independently and in collaboration with

computational chemists for use in Pfizer's compute infrastructure, as

well as lead generation or scaffold hoping tools that became part of a

set of global Lead Generation tools.

. Served as liaison with Research Informatics group to ensure local

computing environment for the Structural and Computational Chemistry

group was properly maintained. Developed and implemented plan to

replace a third of the groups workstations on a yearly basis ensuring

a constant budget expense.

Pfizer, Inc., Ann Arbor, MI 2004 to 2007

Senior Principal Scientist

. As a member of a global team developing application to allow

computational chemists to build and publish QSAR models, implemented

many of the statistical components used, helped define and develop the

standards of the application's components, as well as worked with end-

users ensuring the application met their needs and was easy to use.

This tool has been very well received by computational chemists within

Discovery, PDM, and other groups becoming the preferred tool to

develop and deploys QSAR models.

. Served as leader of a global team that set the best practices and

educating users in the publication of computational models within

Pfizer's internal computing environment. Responsibilities included

organizing team, setting goals, objectives, and holding monthly

meetings. We successfully increased productivity of new model

publications and their use via Pfizer's various global desktop

applications.

. Key developer on a local Java application that bridged the

computational biology and chemistry fields for use in evaluating

targets drugability. Although we stopped development of this

application, the requirements, work-flows, and use cases developed

were incorporated into various global efforts.

Pfizer, Inc., Ann Arbor, MI 2001 to 2004

Research Associate

. As a member of global team developing a molecular visualization

application, set the specifications for accessing and running

computational models published on Pfizer's computational servers,

defined and wrote the User Help documentation used within the

application, as well as involved in developing and giving training

classes on using the application. Also employed Contextual Inquiry and

Use Testing expertise to the application design which has allowed

users to work more efficiently with the application.

. Using my knowledge and expertise in developing computational

models/tools, worked on a global team to define standards for Pfizer's

global computational servers. Because of this, it allowed a smooth

transfer of all models from the local Ann Arbor environment to the

global computational environment enabling the retirement of several

applications, free up local resources and eliminate duplication of

effort saving the company money.

. As a team member to streamline in vitro measurements of ADME/Tox

properties, lead the development and implementation of a web-based

application to calculate in silico ADME/Tox and other properties. The

application was well received and used not only by team members, but

by all scientists at the Ann Arbor laboratories and several other

Pfizer research sites. Many of the best practices established in this

application were incorporated into newer Pfizer tools.

. Key member of the team that formed the BioImaging Center at Pfizer,

Inc.. Based on my experience in using micro-CT to study the structural-

mechanical properties of bone and strong computer background, defined

the specifications for micro-CT usage and computer-network

requirements of the Center.

Warner Lambert, Ann Arbor, MI 1997 to 2001

Senior Scientist

. Lead developer of web based tools which allowed computational chemists

to post alignment, pharmacophore, or docking models to a computational

application server. Medical chemists on numerous projects used these

tools and models to save time by testing hypotheses and/or assessing

how well their ideas for ligands might bind to a target before

actually synthesizing them. Several compounds were nominated for

further development as a direct result of ligands modeled utilizing

these tools.

. Coordinated efforts with Tripos, Inc. to conduct Contextual

Inquiry/Use Testing studies to improve our local web-tools as well as

Tripos's molecular visualization program used by the web-tools. This

effort resulted in much easier and well received tools by Ann Arbor

colleagues; and enabled the vendor to produce a much more marketable

molecular visualization tool.

Warner Lambert, Ann Arbor, MI 1996 to 1997

Senior Systems Programmer

. Collaborated with the Informatics group to develop, setup, and

implement automatic procedures to calculate several in silico

PK/physiochemical properties which were loaded into the global

corporate database; and to automatically update local copies of the

corporate chemical structure database (in 2D and 3D formats) for use

by Ann Arbor computational chemists in their analyses. These

procedures were later adopted by Pfizer in newer database systems.

Warner Lambert, Ann Arbor, MI 1995 to 1996

Systems Programmer

. Maintained and directed system administration for CADD computing

environment, developed proposals/budgets for maintenance and future

enhancements of CADD computing environment, installation of scientific

software, coordinated licensing and software installation with

vendors, and evaluated and recommended new software for the group.

. Acted as liaison between CADD group and Ann Arbor Data Center (AADC)

for computer or networking issues.

. Setup, maintained and served as webmaster for Ann Arbor CADD intranet

website.

University of Michigan, Ann Arbor, MI 1993-1995

Postdoctoral Fellow at the Orthopaedic Research Laboratories, Dept. of

Orthopaedic Surgery

. Developed software upgrades for specific segments controlling the

micro-computed tomography (cone beam scanner developed by Dr. Lee

Feldkamp) system in the Laboratory, and improved elements of the

associated image reconstruction and analyses algorithms. Taught

members of the Orthopaedic Research Labs how to operate the micro-CT

scanner, and worked with them to develop protocols for scanning and

analyzing specimens for their projects.

. Research included the evaluation of a canine osteoarthritis model, the

determination of structural and mechanical properties of cortical bone

in a transgenetic mouse model, failure characterization of vertebral

trabecular bone, and the assessment of structural and mechanical

properties differences due to donor age in human vertebral trabecular

tissue.

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Relevant Skills:

Programming: Perl, HTML, Python, Java, R(statistical)-scripting, MOE

SVL, Daylight Toolkit, FORTRAN, C, JavaScript,

CGI/Bin, CShell

Software Development: Pipeline Pilot protocols, Perl and Python

scripts, Web applications, Java applications,

Java/Swing, GA and other scientific applications for

use in the drug design process, 2D & 3D Image analysis

and visualization programs

Software Packages: Computational Chemistry software (MOE, Tripos,

Daylight, OpenEye, GOLD, Schrodinger), Pipeline Pilot,

Spotfire, Image analysis programs, NetBeans, Eclipse,

Dreamweaver, Microsoft Word, Microsoft Excel,

Microsoft PowerPoint, Microsoft Visio, Statistical

analysis programs

Operating Systems: UNIX, IRIX, Windows 2000/XP-Professional, Linux and

Macintosh

Education:

Ph.D. in Bioengineering December, 1993

The University of Michigan, Ann Arbor, MI

M.S.E. in Bioengineering December, 1986

The University of Michigan, Ann Arbor, MI

M.S.E. in Mechanical Engineering December, 1986

The University of Michigan, Ann Arbor, MI

B.S.E. in Engineering Science May, 1984

The University of Michigan, Ann Arbor, MI

Ongoing professional development courses

Professional Societies / Activities:

Member, The American Chemistry Society

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Professional References:

Available upon request

Publications / Presentations:

Author on Peer Reviewed Journal Articles

. Kibbey, C., Goulet, R.W., Hughes, J., Kuhn, M., Li, D., Luty, B.,

Samuelson, S., Schefzick, S. and Sng, S-T: In silico Model Generator

(isMG): A QSPR Modeling Environment built on a Distributed Computing

Framework, submitted in preparation, 2009.

. McCreadie, BR, Goulet, RW, Feldkamp, LA, Goldstein, SA: Hierarchical

structure of bone and micro-computed tomography. Advances in

Experimental Medicine and Biology, 469: 67-83, 2001.

. Sherick, DG, Buchman, SR, Goulet, RW, Goldstein, SA: A new technique

for the quantitative analysis of cranial suture biology. The Cleft

Palate Craniofacial Journal, 37(1): 5-11, 2000.

. Buchman, SR, Sherick, DG, Goulet, RW, Goldstein, SA: Use of

microcomputed tomography scanning as a new technique for the

evaluation of membranous bone. The Journal of Craniofacial Surgery,

9(1): 48-54, 1998.

. Zysset, P.K., Goulet, R.W., Hollister, S.J.: A global relationship

between trabecular bone morphology and homogenized elastic properties.

Journal of Biomechanical Engineering, 120(5):640-646, 1998.

. Guldberg, RE, Caldwell, NJ, Guo, XE, Goulet, RW, Hollister, SJ,

Goldstein, SA: Mechanical stimulation of tissue repair in the

hydraulic bone chamber. Journal of Bone and Mineral Research, 12(8):

1295-302, 1997.

. Jepsen, KJ, Schaffler, MB, Kuhn, JL, Goulet, RW, Bonadio, J,

Goldstein, SA: Type I collagen mutation alters the strength and

fatigue behavior of Mov13 cortical tissue. Journal of Biomechanics,

30(11-12): 1141-7, 1997.

. Dedrick, DK, Goulet, RW, O'Connor, BL, Brandt, KD: Preliminary

report: increased porosity of the subchondral plate in an accelerated

canine model of osteoarthritis. Osteoarthritis and Cartilage, 5(1): 71-

4, 1997.

. Goulet, R.W., Goldstein, S.A., Ciarelli, M.J., Kuhn, J.L, Brown, M.B.,

Feldkamp, L.A.: The relationship between the structural and

orthogonal mechanical properties of trabecular bone. Journal of

Biomechanics, 27(4):375-389, 1994.

. Dedrick, D.K., Goldstein, S.A., Brandt, K.D., O'Connor, B.L., Goulet,

R.W., Albrecht, M.: A longitudinal study of subchondral plate and

trabecular bone in cruciate-deficient dogs with osteoarthritis

followed up for 54 months. Arthritis & Rheumatism, 36(10): 1460-1467,

1993.

. Goldstein, S.A., Goulet, R.W., and McCubbrey, D.A.: Measurement and

significance of three dimensional architecture to the mechanical

integrity of trabecular bone. Calcif. Tissue Int., 53(Supp 1): S127-

S133, 1993.

. Fyhrie, D.P., Fazzalari, N.L., Goulet, R.W., Goldstein, S.A.: Direct

calculation of the surface-to-volume ratio for human cancellous bone.

Journal of Biomechanics, 26(8):955-967, 1992.

. Dedrick, D.K., Goulet, R., Huston, L., Goldstein, S.A., Bole, G.G.:

Early bone changes in experimental osteoarthritis using microscopic

computed tomography. Journal of Rheumatology, 27(18):44-45, 1991.

. Kuhn, J.L., Goldstein, S.A., Feldkamp, L.A., Goulet, R.W., Jesion, G.:

Evaluation of a microcomputed tomography system to study trabecular

bone structure. Journal of Orthopaedic Research, 8(6):833-842, 1990.

. Kuhn, J.L., Goulet, R.W, Pappas, M., Goldstein, S.A.: Morphometric and

anisotropic symmetries of the canine distal femur. Journal of

Orthopaedic Research, 8(5):776-780, 1990.

. Layton, M.W., Goldstein, S.A, Goulet, R.W., Feldkamp, L.A., Bole,

G.G.: Examination of subchondral bone architecture in experimental

osteoarthritis by microscopic computerized axial tomography. Journal

of Arthritis and Rheumatism. 31(11):1400-1405, 1988.

Author on Published Abstracts

. Ortwine, D.F., Dunbar, B.W., Goulet, R.W., Humblet, C.; Lunney, E.A.;

Narasimhan, L.; O'Donnell, T.J.; Rojnuckaran, D.: Modeling on the

web: Intranet-based drug design software. 224th ACS National Meeting,

Boston, MA, United States, August 18-22, 2002.

. Blankley, C.J., Gifford, E., Goulet, R.W., Humblet, C., O'Donnel, TJ:

WebPK. 5th Annual Drug Discovery Symposium, PGRD Ann Arbor

Laboratories, 2000.

. Goulet, R.W., Hollister, S.J.: Determination of minimum

microstructural analysis volumes for trabecular bone using 3-D

stereology and FFT analysis. Trans. of Ortho. Res. Soc., 21:715,

1996.

. Smith, E.A., Guo, X.E., Goulet, R.W., Hollister, S.J., Goldstein,

S.A.: Prediction of local strains in human vertebral bone specimens

using CT-based finite element models. Trans. of Ortho. Res. Soc.,

21:604, 1996.

. Guo, X.E., Weissman, D.E., Goulet, R.W., Hollister, S.J., Derwin,

K.A., Goldstein, S.A.: Characterization of local failure in vertebral

trabecular bone. Trans. Orthop. Res. Soc., 20, 1995.

. Dedrick, D.K., Goulet, R.W., O'Connor, B.L., Brandt, K.D.: Changes in

subchondral plate and cancellous bone in an accelerated canine model

of osteoarthritis. Trans. Orthop. Res. Soc., 20, 1995.

. McCubbrey, D.A., Mascha, E.J., Goulet, R.W., Goldstein, S.A.:

Relationships between trabecular architecture and failure properties

of whole vertebrae in the beagle. Trans. Orthop. Res. Soc., 19(1):55,

1994.

. McCubbrey, D.A., Yian, E.H., Goulet, R.W., Shih, M-S., Parfitt, A.M.,

Goldstein, S.A.: The effects of calcitonin on trabecular bone

properties in the ovariectomized beagle. Trans. Orthop. Res. Soc.,

18(1):53, 1993.

. McCubbrey, D.A., Cody, D.D., Gross, G.J., Goulet, R.W., Goldstein,

S.A.: Relationships between cancellous density, architecture, and

material properties of the human proximal femur. Trans. 9th

International Workshop on Bone Densitometry, 1992.

. Goulet, R.W., Feldkamp, L.A., Goldstein, S.A.: Quantification of the

architecture of cancellous bone by surface and volume orientation

methods. Trans. of Ortho. Res. Soc., 17:159, 1992.

. McCubbrey, D.A., Goldstein, S.A., Cody, D.D., Goulet, R.W., and Kuhn,

J.L.: The regional density, architectural, and tissue properties of

vertebral trabecular bone and their relation to whole bone failure

properties. Trans. ASME Winter Annual Mtg., 20:575-578, 1991.

. Dedrick, D.K., Goulet, R.W., Widmer, W.R., O'Connor, B.L., Brandt,

K.D., Goldstein, S.A.: Evaluation of trabecular bone in

experimentally induced canine osteoarthritis. Trans. Ortho. Res.

Soc., 16:332, 1991.

. McCubbrey, D.A., Goulet, R.W., Goldstein, S.A., Shulick, A.M.:

Vertebral body architecture and mechanical properties alterations due

to ovariectomy in the beagle. Trans. Ortho. Res. Soc., 16:284, 1991.

. Dedrick, D.K., Brandt, K., Goulet, R.W., Goldstein, S.A., O'Connor,

B.: Subchondral plate (SP) and trabecular (T) bone in experimental

osteoarthritis (OA). Arthritis and Rheumatism, 33(9):S91, 1990.

. Goldstein, S.A., Kuhn, J.L., Goulet, R.W., Choi, K., Hollister, S.J.,

Ciarelli, M.J., Matthews, L.S.: Properties and remodeling of

trabecular bone. First World Congress of Biomech., 2:210, 1990.

. Goldstein, S.A., Goulet, R.W., Kuhn, J.L., Feldkamp, L.A.:

Experimental data on cancellous bone architecture. First World

Congress of Biomech., 2:45, 1990.

. Hollister, S.J., Goulet, R.W., Goldstein, S.A.: Predicting trabecular

bone stiffness using two methods of microstructural analysis. First

World Congress of Biomech., 1:210, 1990.

. Hollister, S.J., Goldstein, S.A., Jepsen, K.J., Goulet, R.W.:

Continuum and microstructural stress morphology relationships for

trabecular bone subject to controlled implant loads. Trans. Ortho.

Res. Soc., 15:74, 1990.

. Dedrick, D.K., Goldstein, S.A., Goulet, R.W., Bole, G.G.: Early bone

changes in experimental osteoarthritis. Arthritis and Rheumatism,

23(4):1095, 1989.

. Goulet, R.W., Feldkamp, L.A., Kubinski, D.J., Kuhn, J.L., Goldstein,

S.A.: Predicting the architectural orientation of trabecular bone.

Trans. Ortho. Res. Soc., 14:263, 1989.

. Kuhn, J.L., Goulet, R.W., Goldstein, S.A., Feldkamp L.A.: A study of

the variation of trabecular architectures in small volumes of bone

using a micro-computed tomography system. J. Biomech., 21(10):853,

1988.

. Layton, M.W., Goldstein, S.A., Goulet, R.W., Feldkamp, L.A., Bole,

G.G.: Evaluation of subchondral bone architecture in experimental

osteoarthritis by microscopic computerized axial tomography. Trans.

Ortho. Res. Soc., 13:489, 1988.

. Goldstein, S.A., Kuhn, J.L., Hollister, S.J., Goulet, R.W., Loubert,

P.V., Sweet, K., Matthews, L.S.: The relationship between

experimentally controlled loads and trabecular bone remodeling.

Trans. Ortho. Res. Soc., 13:102, 1988.

. Goulet, R.W., Ciarelli, M.J., Goldstein, S.A., Kuhn, J.L., Feldkamp,

L.A., Kruger, D., Viviano, D., Champlain, F., Matthews, L.S.: The

effects of architecture and morphology on the mechanical properties of

trabecular bone. Trans. Ortho. Res. Soc., 13:73, 1988.

. Goldstein, S.A., Ku, J.L., Hollister, S.J., Goulet, R.W., Champlain,

F.W., Matthews, L.S.: Experimentally controlled trabecular bone

remodeling: effects of applied stress. Trans. Ortho. Res.Soc.,

12:461, 1987.

. Goldstein, S.A., Ku, J.L., Goulet, R., Feldkamp, L.A., Ciarelli, M.,

Kruger, D., Jesion, G., Matthews, L.S.: The relationship between

three-dimensional architecture of trabecular bone and its mechanical

properties. 1987 Biomechanics Symposium, Amer. Soc. Mech. Engin.,

84:287-89, June 1987.

Presentations at National Conferences

. "An Integrated Desktop Computing Environment for Chemists", presented

at the Bridging Pharma and IT conference, Boston, MA, September, 2007.

. "Computational Chemistry Desktop Applications For Chemists", presented

at the CHI Intelligent Drug Discovery & Development Conference,

Philadelphia, PA, May, 2003.

. "Making WebTools work for Chemists", presented at the 6th

International Conference on Chemical Structures, in The Netherlands,

June, 2002.

. "Quantification of the Architecture of Cancellous Bone by Surface and

Volume Orientation Methods", presented at the 38th meeting of the

Orthopaedic Research Society, Washington, DC, February, 1992.

. "Predicting the Architectural Orientation of Trabecular Bone,"

presented at the 35th meeting of the Orthopaedic Research Society, Las

Vegas, NV, February, 1989.

. "The Effects of Architecture and Morphology on the Mechanical

Properties of Trabecular Bone," presented at the 34th meeting of the

Orthopaedic Research Society, Atlanta, GA, February, 1988.

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