Project Design
Resume:
[pic] Deepak S. Panmand
Camerino University,
Via Sant Agostino 1,
(MC), italy 62032.
E@- *********@*****.***
I would like commence my research career in following areas:
1) Medicinal Chemistry (Designing, synthesizing and developing
pharmaceutical drugs).
2) Synthetic chemistry (asymmetric synthesis) (new synthetic methodology to
execute a desired product).
3) Total synthesis of natural product. (New strategies for the preparation
of complex molecules possessing interesting structural, biological, and
physical properties).
M.Sc. (Organic Chemistry) (2years full time)
Organic chemistry (2004), S.P.College, Pune Department of Chemistry,
University of Pune, Pune-411 030, INDIA. Marks: 64.68% First class.
http://www.unipune.ac.in/
Specialization: Organic Chemistry.
Major Subject(s): Reaction Mechanisms, Heterocyclic Chemistry,
Spectroscopy, Stereochemistry, Organometallic
Chemistry, Retrosynthesis,
Natural Product, Pericyclic Reactions, Photochemistry.
Elective Subject(s): Physical Chemistry, Inorganic Chemistry and
Analytical Chemistry.
B.Sc. (Chemistry, Zoology, Botany, Physics) (3 years full time)
B.Sc. Chemistry (2002), Ale College Junner, University of Pune.
Marks: 73.8 % First class with distinction.
Specialization: Chemistry.
Subject(s): Organic Chemistry, Physical Chemistry, Inorganic
Chemistry, Industrial Chemistry, Analytical and Nuclear Chemistry.
H.Sc. (Chemistry, Physics, Biology) (2yrs full time) (1997-99) Pune
Divisional (M.S.) Board, INDIA. Marks: 62.68 % First class.
1. Synthetic chemistry, including functional group inter-conversions,
protecting group's strategies and basic reaction mechanisms.
2. Specialised in organic synthesis, Organometallic and natural product
molecules.
3. Well familiar with Sci-finder, belstine search, chemdraw for reactions
and reagents.
4. Expertise in suggesting possible solutions to routine problems with
work-up, moisture sensitive reagents handling and experimental set up.
5. Well versed with medicinal chemistry principles.
6. Proficient in the use of NMR (1H, 13C, 13C DEPT, 1D NOE, 2D OE, 19F),
MS, LCM and IR techniques for structural characterisation and able to
interpret spectra.
7. Practical knowledge of a range of purification techniques and equipment
such as re-crystallization, flash chromatography, TLC, vacuum distillation,
HPLC purification. I can work in the team with good team spirit for
achieving overall team goals while achieving personal goal in stipulated
time.
8. Experience in synthesizing NCE's, Library synthesis of therapeutically
relevant molecules.
9. Expertise in safe handling of pyrophoric (n-BuLi, LDA, LAH
etc
Toxic (KCN) and other hazardous Reagents.
10. Multi step synthesis of therapeutically relevant organic
molecules as
a part of drug discovery program.
12. Acquaintance with chemdraw and ISISI draw, MDL, Sci-Finder
and
Discovery Gate for literature search and MS office.
13. Sound written and verbal skills.
Name reactions : Appel reaction, Baylis-Hillman reaction, Buchwald-Hartwig
coupling, Suzuki coupling, Curtius rearrangement, Dess-Martin periodinane,
Etard reaction, Fischer-indole synthesis, Gabriel Synthesis, Grignard
reaction, Heck reaction, Horner-Emmons reaction, Jones oxidation,
Knovengel condensation, Kolbe-Schmidt reaction, Leuckart reaction,
Lawesson's reagent, Meth-Cohn quinoline synthesis, Mitsunobu reaction,
Peterson olefination, Pinner reaction, Pfitzinger quinoline synthesis,
Swern oxidation, Suzuki coupling, Staudinger reduction, Simmon-Smith
reaction, Weinreb Keton synthesis, Wittig reaction.
1) Ipca laboratories Ltd, Mumbai:
Jr.R&D officer (Process research R & D)
> Responsible for the design, synthesis, purification and shipping
of API (process chemistry) for clients on milligram to kilogram
scale.
> Characterisation and synthesized compounds with NMR, HPLC, GC-
MS, LC-MS and IR.
> Present written reports to clients in timely and orderly
fashion, supervise/ mentor junior recruits.
> Development of non infringing synthetic route for generic drugs
or API for large scale synthesis.
> Design, synthesis, optimization, scale up, impurity profiling,
technology transfer for plant scale preparation.
2) Glenmark Pharmaceutical ltd, Mumbai:
Research Associates1 (Drug Discovery R&D)
> Designing synthesis, purification and characterisation of novel
molecules for biological evaluation.
> Find the best possible synthetic route by doing online (Sci-finder,
bel stine search).
> Carry out reaction individually, purification by column chromatography
and interpretation of analytical data.
> Study of SAR data from the results of biological study; propose new
molecules based on this study.
> Maintain all details and accurate data of all lab records.
> Maintain the online database for all the molecules synthesized in the
group.
1. Project Completed ONDENSETRON (Patent Information)
An industrial one pot process for the preparation of 1,2,3,9-tetrahydro-9-
methyl-3-[(2-methyl)-1H-imidazole-1-yl)methyl]-4H-carbazole-4-one
(Ondensetron) starting from 1,2,3,9-tetrahydrocarbazole-4-one in high yield
and purity. Publication No. WO2006046253.
Therapeutic activity:
Used as a Automating drug and Reduces nausea in Chemotherapeutic treatment.
< PhD Research works at Camerino University of Italy:
Presently working on Purinergic receptor area;
. Synthesis of novel ligand (Antagonist) for P2X3 receptor.
. Synthesis of potent agonist for P2X3 receptor (Nucleotide
Chemistry).
. Synthesis of new ligand for G-protein coupled receptor.
1. Design, synthesis, and biological activity of new P2X3 receptor ligands
Panmand Deepak Shankara, Volpini Rosariaa, Dal Ben Diegoa, Lambertucci
Catiaa, Nistri Andreab, Cristalli Gloriaa.
1Dip. Scienze Chimiche, University of Camerino, I-62032 Camerino, Italy
2Sector of Neurobiology, International School for Advanced Studies (SISSA),
I-34014 Trieste, Italy.
2. Synthesis of new adenine derivatives as "adenine receptor" ligands
Deepak S. Panmanda, Gloria Cristallia, Ippolito Antoninia, Diego Dal Bena,
Catia Lambertucci,a Christa E. M ller,b Rosaria Volpinia
a Department of Chemical Sciences, University of Camerino, Via S. Agostino
1, 62032 Camerino, Italy; . b PharmaCenter Bonn, University of Bonn, An der
Immerburg 4, 53121 Bonn, Germany.
3. Design, synthesis, and biological activity of new GPR17 receptor
ligands
Panmand Deepak Shankar,1 Volpini Rosaria,1 Dal Ben Diego,1 Lambertucci
Catia,1 Ramadori Anna Teresa,1 Nistri Andrea,2 Cristalli Gloria.1
1Dip. Scienze Chimiche, University of Camerino, I-62032 Camerino, Italy
2Sector of Neurobiology, International School for Advanced Studies (SISSA),
I-34014 Trieste, Italy.
1. M. Buccioni1, D. Dal Ben1, C. Lambertucci1, G. Marucci1, D. S. Panmand1,
R. Volpini, G. Cristalli1.
Evaluation of biological activity at adenosine A2A receptor of 8-
substituted 9-ethyladenine derivatives with a new immunoassay method.
XIX National Meeting on Medicinal Chemistry, Verona - Italia 14-18
Settembre 2008.
2. G. Cristalli1, I. Antonini1, D. Dal Ben1, C. Lambertucci1, D. S.
Panmand1, C. E. M ller1, R. Volpini1.
Synthesis of new adenine derivatives as "adenine receptor" ligands.
XXIII Congresso Nazionale Societ Chimica Italiana, Sorrento 5-9 Luglio
2009.
3. D. S. Panmand1, D. Dal Ben1, D. Giacobbe1, C. Lambertucci1, G. Marucci1,
R. Volpini1, A. Nistri2, G. Cristalli1.
Substituted adenine derivatives as novel P2X3 receptor ligands.
Third Joint Italian-German Purine Club Meeting - Purinergic Receptors: New
Frontiers for Novel Therapies, Camerino - Italy, July 17-20, 2009.
4. Volpini R.,1 Dal Ben Diego,1 Giacobbe Dania,1 Lambertucci Catia,1
Panmand Deepak Shankar,1 Ramadori Anna Teresa,1 Nistri Andrea,2 Cristalli
Gloria1.
Design, synthesis, and biological activity of new P2X3 receptor ligand.
34 Congresso Nazionale della Societ Italiana di Farmacologia
Rimini, Palacongressi 14-17 Ottobre 2009.
4. D. S. Panmand,1 C. Lambertucci,1 D. Dal Ben,1 G. Marucci,1 R. Volpini,1
A. Nistri,2 G. Cristalli1.
Synthesis of novel ligands for P2X3 receptor.
Trekking through Receptor Chemistry, 28th Camerino-Cyprus-Noordwijkerhout
Symposium Camerino, May 16-20, 2010.
5. D. S. Panmand1.
"Novel ligand for P2X3 and GPR17 receptors"
European School of Medicinal Chemistry"- (Italy) Urbino September 13-18,
2010.
6. "European School of Medicinal Chemistry"- (Italy) Urbino September 13-
18, 2007.
7. "European School of Medicinal Chemistry"- (Italy) Urbino September 13-
18, 2008.
< ONDENSETRON PROJECT:
Initially I was working in Ipca Lab; I worked there on two projects
Ondensetron and Ubiquinone. Our aim was to develop process for active
pharmaceutical ingredients (API), reduce manufacturing cost of drug and
availability with good yield and purity, Stability and solubility.
Ondensetron is used in chemotherapy and reduce nausea. The main
Objective of invention was, to carry out reaction in one pot process and
improve the rate of reaction, yield, selectivity, quality and ease with
which Ondensetron separated from reaction mixture.
Contribution: Introduction of side chain to Methyl Keto Indole and N-
alkylation's of 2-methylImidazole.
In Most of the patents dedicated their efforts on a final state of
Ondensetron. Ondensetron was prepared from an intermediate exomethylene it
was isolated and then doing further reaction and it gives poor yield and
quality of resulting intermediate is lower overall yield /purity of
Ondensetron and reaction was taking 48-50 hr with formation of Polymeric
Impurities. Maintain a proper ratio of solvent (Hydrocarbon acidic
condition) temperature and time 5-6 hrs with 90 to 92% yield and purity 98
to 99% .
< Reaction scheme for the synthesis ONDENSETRON:
[pic]
< Ubiquinone/COQ10:
Therapeutic Use anti oxidant and cardiovascular, anticancer drug.
In this project there was a need of trans Isomer it was achieved by
Wittig reaction under proper condition and temperature and Coupling of
decaprenol and COQ10 was improved lot and reduce the reaction time.
First Route:
[pic]
Second Route:
Synthesis of COQ10 by using Grignard reaction as a key step. CoQ10 is
synthesized by novel route as per prior art.
[pic]
< Synthesis of 2(4-Bromo acrylic acid):
[pic]
< GPR-120 agonists:
Synthesis several no. of GPR-120 agonist based on Thiazolidinone as a main
pharmacophore. Following intermediates are synthesized to produce several
no. of compounds.
[pic]
> 4. Synthesis of new chemical entity: (Glenmark Pharmaceutical Ltd).
I have successfully worked in this project and I prepared library 150
to 200 molecule in last few years.
In this involved 13 to 15 step in each scheme
[pic]
A library of 50 to 100 compounds was prepared and tested biological
activity in various Therapeutic areas.
< 5. Mitogen Activated protein Kinease (Lupin Pharmaceutical Ltd):
India's third leading company in pharmaceutical manufacturing. I am
working in drug discovery dept. here I have synthesized standard molecule
of MAPK inhibitor.
[pic]
< 6. Synthesis agonist analogue for P2X3 receptor:
[pic] Adenosine
meATP
[pic]
Adenosine
meATP
I have qualified the Graduate Aptitude test in Engineering (GATE). My
GATE score is 87%. Examination was conducted by the seven Indian Institute
of Technology and Indian Institute of Science, Banglore, on behalf of the
National Coordinating Board GATE.
Objectives of GATE are at National level, meritorious and motivated
candidates for admission to postgraduate program in engineering,
technology, architecture, science and pharmacy.
I hope this opportunity will helpful to prove my chemistry knowledge
and strengthen my career, I will shoulder the responsibilities given by
your institute and will prove an asset for your organization.
January: 2010 International English Language Testing System (IELTS), Scored
Band Score of 6.0.
1) Report writing, group work, information, retrieval and oral
presentation.
2) Professional development for example skills in literature search,
distinguishing between types of information available, critical analysis of
literature, preparing and delivering oral presentation,extensive use of
computers laboratory report writing, scientific assay writing and team
work.
3) Have a basic understanding of the theoretical principles involved in
general area and Have a capability to work independently and
collaboratively.
4) Read magazines of pharma news and different journals.
5) Excellent time management skill and ability to work independently.
6) Ability to efficiency organizes tasks, data and documentation and
ability to compete multiple tasks quickly and efficiently.
7) An introduction to some of the scientific, ethical, moral and legal
concerns related to some aspects of medicinal chemistry.
I am Deepak S. Panmand, hereby declare that the information stated in
these Curriculum Vitae is true and correct to the best of my knowledge.
Place: Italy. Yours
Sincerely,
(Deepak
S. Panmand)
Curriculum Vitae
Research interest
Academic details
Practical Skills
Professional Experience
Publication/Patent
Industrial Research Work
Declaration
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IELTS
Professional Skills and Competences
Publications in PhD Program (under review):
Oral and Poster Presentations
Contact this candidate