CURRICULUM VITAE- Oren M. Milstein, Ph.D.

Oren Milstein, Ph.D. Tel/Fax: +1-858-***-****

***** *** ******,

San Diego 92129

Cell: +1-858-***-****

Citizenship: U.S.A., Israel E-mail: abl1au@r.postjobfree.com

EDUCATION, RESEARCH & TRAINING:

2010-Present Postdoctoral Fellow, The Salk Institute for Biological Studies, La

Jolla, CA

Supervisor: Dr. Ye Zheng.

Subject of research: Mechanisms of regulatory T cell suppression of

autoimmunity.

2008-2009 Postdoctoral Fellow, The Department of Genetics, The Scripps

Research Institute, La Jolla, CA

Supervisor: Prof. Bruce Beutler.

Subject of research: Forward genetic analysis of mammalian

susceptibility to viral infection.

2008 Postdoctoral Fellow, The Department of Immunology, Weizmann

Institute of Science, Rehovot, Israel.

Supervisor: Prof. Yair Reisner.

Subject of research: The mechanism by which cytotoxic T cells

respond with activation and granule secretion when serving target

for T cell recognition.

2001-2008 Ph.D. in Life Sciences- Direct Track, Weizmann Institute of

Science, Rehovot, Israel.

Supervisor: Prof. Yair Reisner.

Thesis title: Sparing and reconstituting the host immune system in

allogeneic stem cell transplantation: specific tolerance induction

by donor CTLs and adoptive transfer of host T cells.

2005 As part of my PhD I spent the whole year in the laboratory of Prof.

Michael Dustin at NYU in a collaborative effort. I received

training on confocal microscopy and other imaging techniques.

Additionally, I conducted research on the immune synapse that

resulted in a first author publication. Funded by EMBO. Supervised

by Prof. Michael Dustin.

2002 M.Sc in Life Sciences obtained, Weizmann Institute of Science,

Rehovot Israel.

Supervisor: Prof. Yair Reisner.

Subject of research: Adoptive transfer of non-alloreactive host T

cells for overcoming influenza in a mouse model of immune

reconstitution after mismatched hematopoietic stem cell

transplantation.

2000-2001 Program towards Doctor of Veterinary Medicine (DVM), Koret School

of Veterinary Medicine, The Hebrew University of Jerusalem.

1997-2000 B.Sc. Honors in Animal Science, The Hebrew University of Jerusalem.

ACADEMIC AWARDS and FELLOWHIPS:

2008-2009 NIH Postdoctoral Training Grant in Immunology, The Immunology

Training Program at The Scripps Research Institute

2005 EMBO short term fellowship (ASTF.49.00-05)

LABORATORY TECHNIQUE EXPERTISE

Proficient in all common techniques of Protein Analysis, Cell Biology and

Immunology including both in-vitro and in-vivo models.

TEACHING ACTIVITY

2005-2007 Guiding M.Sc. students in our group at the Weizmann Institute and

training other lab members on various imaging techniques.

2001-2005 Science teacher with the young@science organization the Weizmann

Institute. Duties included frontal presentation and tutoring in the

fields of biology and chemistry.

1999-2001 Volunteer science teacher at the 'Kiryat Moshe' regional council.

Duties included frontal presentation and tutoring of

underprivileged students of diverse ethnic backgrounds in the

fields of Biology, Chemistry and English.

MILITARY SERVICE: ISRAELI DEFENSE FORCE

1994-1997 Radar specialist on an Israeli Navy vessel and later Head of

Security and commander of reserve service personnel in an Israeli

Navy regional radar station.

SCIENTIFIC WRITING

2010 Wrote a grant proposal to the Department of Defense to obtain funding

for Bone Marrow Failure research titled "Evaluating the role of

autoimmunity in radiation-induced bone marrow failure". Under Review

2010 Wrote the manuscript summarizing my latest research with the Reisner

lab at the Weizmann Institute titled "CTLs respond with activation and

granule secretion when serving target for T cell recognition".

Accepted for publication in Blood- the most cited peer-reviewed

publication in the field of Hematology.

2009 Successfully planned and wrote a research proposal to the National

Institutes of Health (NIH) for which I received funding for my

Post-Doctoral training at the Scripps Research Institute in La Jolla,

CA.

2008 Conceived, wrote and successfully defended my PhD thesis.

2008 Wrote the manuscript summarizing my research with the Dustin lab at

NYU titled "Nanoscale increases in CD2-CD48 mediated intermembrane

spacing decrease adhesion and reorganize the immunological synapse".

Published in the Journal of Biological Chemistry.

2005 Conceived and wrote a research proposal to the European Molecular

Biology Organization (EMBO) for which I obtained funding for

scientific collaboration with the Dustin lab at NYU in New York City.

LANGUAGES

English Fluent

Hebrew Mother tongue

APPENDIX: Publications, Proceedings and Presentations

Peer-reviewed Publications:

. Milstein, O., Hagin, D., Lask, A., Reich-Zeliger, S., Shezan

E., Ophir E., Eidelshtein Y., Afik R., Antebi YE., Dustin ML.

and Reisner Y. CTLs respond with activation and granule

secretion when serving target for T cell recognition. Blood

-Accepted (August 2010).

. Tchorsh-Yutsis D, Hecht G, Aronovich A, Shezen E, Klionsky Y,

Rosen C, Bitcover R, Eventov-Friedman S, Katchman H, Cohen S,

Tal O, Milstein O, Yagita H, Blazar BR, Reisner Y. (2009). Pig

embryonic pancreatic tissue as a source for transplantation in

diabetes: transient treatment with anti-LFA1, anti-CD48, and

FTY720 enables long-term graft maintenance in mice with only

mild ongoing immunosuppression. Diabetes 58, 1585-94

. Milstein, O., S.Y. Tseng, T. Starr, J. Llodra, A. Nans, M. Liu,

M.K. Wild, P.A. van der Merwe, D.L. Stokes, Y. Reisner, and

M.L. Dustin. (2008). Nanoscale increases in CD2-CD48 mediated

intermembrane spacing decrease adhesion and reorganize the

immunological synapse. J Biol Chem. 283, 34414-22.

. Dekel, B., Burakova, T., Arditti, F. D., Reich-Zeliger, S.,

Milstein, O., Aviel-Ronen, S., Rechavi, G., Friedman, N.,

Kaminski, N., Passwell, J. H., and Reisner, Y. (2003). Human

and porcine early kidney precursors as a new source for

transplantation. Nature Med 9, 53-60.

. Katz, U., Bracha, R., Nuchamowitz, Y., Milstein, O., and

Mirelman, D. (2003). Comparison between constitutive and

inducible plasmid vectors used for gene expression in Entamoeba

histolytica. Mol Biochem Parasitol 128, 229-233.

Publications in Preparation:

. Milstein, O., Berger, M., Krebs, P., Beutler B., Du, X. The

ATP4a gene serves a non-redundant role in controlling

hematopoietic function in SubLytic mice.

. Milstein, O., Reich-Zeliger, S., Lustig, E. and Reisner Y.

Adoptively transferred host T cells overcome influenza without

graft rejection in a mouse model of immune reconstitution after

mismatched hematopoietic stem cell transplantation.

Conference proceedings:

. Milstein, O., Reich-Zeliger, S. Lask, A.,Seger, R. and Reisner,

Y. Tolerance Induction by Veto CD8 T Cells: Mechanisms of TCR

Independent Killing. (Abstract) Accepted for Presentation at

the 5th (2008) Congress of the Federation of the Israel

Societies for Experimental Biology - FISEB (ILANIT).

. Milstein, O., Lask, A., Reich-Zeliger, S. and Reisner, Y. A

Novel Mechanism for CTL Veto Activity: CTLs Respond to

Recognition by Alloreactive T cell with Activation and

Cytotoxic Granule Secretion. (Abstract) Accepted for

Presentation at the 2007 American Society of Hematology Annual

Meeting.

. Lask, A., Goichberg P., Goren-Arbel R., Milstein O., Aviner S.,

Feine I., Klein T., Berrebi, A., and Reisner, Y. Eradication

of B cell malignancies by anti-3rd party CTLs: A novel role for

MHC class I. (Abstract) Accepted for Presentation at the 2007

American Society of Hematology Annual Meeting.

Oral Presentations

. The Role of ERK in Anti-Third Party CTL-Mediated Apoptosis of

Alloreactive T cells. Oral Presentation at the RISET Consortium

Meeting Brussles, Belgium. Oct. 2006.

. Tolerance Induction by Veto CD8 T Cells: Mechanisms of TCR

Independent Killing. Oral Presentation at the 5th (2008)

Congress of the Federation of the Israel Societies for

Experimental Biology - FISEB (ILANIT).

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