Design Software

MONICA BROWN NORTON

**** ******* **, #*** 314-***-****

St. Louis, MO 63146 636-***-****

abjtyt@r.postjobfree.com

Summary

Talented Medicinal/Pharmaceutical Chemist focused on early hit-to-lead and lead

optimization. Adept in small molecule drug design to achieve potent, selective, drug-like

candidates. Recognized for analog quality, quickly delivering products, and exceeding

critical deadlines.

Skills

Design HPLC Solid Phase Synthesis MS Word/ EXCEL/ PowerPoint

Multi-step Synthesis NMR Bioconjugation Sci-Finder

Purification LC-MS Library Design and Synthesis PatBase

Data Analysis GC-MS Data Management & Mining MDL Discovery Gate

Analog QC Preparative LC ChemDraw Spotfire

Outsourcing Genevac SharePoint

Selected Accomplishments

Hit-to-Lead/Lead Optimization:

• Improved drug-ability through structure activity relationship analysis and medicinal chemistry

strategies.

• Designed and synthesized small and large targeted libraries (in-house and external vendors).

Synthetic Skills:

• Executed multi-step syntheses, including inert atmosphere, light sensitive, organometallic,

palladium catalyzed, heterocyclic chemistry, hydrogenation, low temperature (-100ºC),1 mg to 1 kg

reaction scale.

• Utilized modern purification and analytical techniques: normal and reverse phase LC,

crystallization, TLC, distillation, dialysis, solid support and resin applications, NMR, LC-MS, GC/MS,

UV-VIS and IR.

• Conjugated small molecules and peptides to proteins to create novel therapeutics.

• Performed solid and solution phase peptide synthesis utilizing natural and

non-natural amino acids and non-peptidic synthesis techniques for peptide

modification.

Outsourcing:

• Developed productive relationships with external vendors and contract research

organizations (CRO) in China, India and Netherlands.

Professional Experience

Pfizer, Inc. (formerly Pharmacia, Corp./Monsanto Corp.), St. Louis, MO 1998 - 2010

Senior Scientist, Medicinal Chemistry

Designed and synthesized novel analogs in cardiovascular, oncology and inflammatory

disease targets. Specialized in achieving kinome selectivity.

Monica Brown Norton Page 2

• Advanced two projects to lead development by utilizing data and modeling

tools to design and synthesize potent, orally bioavailable small molecules for

selectivity and pharmacokinetic properties; discovered SAR that led to eventual

First In Human candidate.

• Expanded SAR by designing and developing synthetic methodology for

internal or external synthesis of small targeted libraries.

• Received Pfizer Personal Achievement Award for scale-up (100 mg to 12 g)

and isolation of 99.9%+ pure compound for key project milestone.

• Synthesized key cyclic peptides to evaluate technology of external

collaborator.

• Explored the conjugation of small molecules and peptides to proteins to

improve biological properties utilizing knowledge of medicinal chemistry and

biochemistry.

• Managed CRO submissions, provided troubleshooting, tracked contract

research organization progress, reviewed reports and processed compounds

through testing funnel.

• Improved CRO time lines for completed requests and assay submissions.

Worked with outsourcing group to improve CRO software interface. Efforts led to

Chemistry Sourcing Difference Maker Award.

• Analyzed synthesized compounds by HPLC, LC-MS and NMR, for purity and

structure confirmation.

• Beta tested new organizational software in conjunction with global IT and

analytical department then trained colleagues on new software and laboratory

procedures leading to more efficient process for sample purification and data

retrieval.

• Maintained laboratory instrumentation: Gilson preparative reverse phase

HPLC, Agilent HPLC, Waters LC-MS, Genevac, lyophilizer, Biotage normal phase

preparative HPLC.

Education

B. A. Chemistry, WESTMINSTER COLLEGE, Fulton, Missouri

Professional Development

ADMET Case Studies from a Medicinal Chemistry Perspective, CHI, 2007

Savvy Medicinal Chemist Workshop, Pfizer, Inc, 2006

Statistics for Non-Statisticians, Pfizer, Inc, 2006

Advancing Library Design and Organic Synthesis, CHI, 2005

Medicinal Chemistry Workshop, Pfizer, Inc. 2005

Catalysis in Modern Organic Synthesis, ACS ProSpectives Series, 2003

Accelerated Chemical Discovery: From Drugs to Catalysts, ACS Short Course, 2002

Practical Medicinal Chemistry, Prof. Lester A. Mitscher, 2000

Synthetic Organic Chemistry: Modern Methods and Strategies, ACS Short Course,

1999

Basic Pharmacology, University of Wisconsin, Madison, 1994

Monica Brown Norton Page 3

Honors and Awards

Individual Performance Award, Pfizer, Inc, 2009, 2007

Co-recipient of Pfizer Team Award for Excellence, 2009

Chemistry Sourcing Difference Maker Award, Pfizer, Inc, 2007

G. D. Searle ACE Achievement Award, 1993

Patents and Publications

Twelve external publications, 38 issued patents and one patent application

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