Quality Control Manager

PARTHA S MITRA

LAB ADDRESS

Department of Biology, Room 408, EE Just Hall

*** ******* ******, **, ********** DC 20059, USA

Tel: 202-***-****

RESIDENCE

**** ******** ******, *** *** MD, United States

Phone; 301-***-****

Email: ************@*****.***, *******@******.***

OBJECTIVE:

Seeking a suitable position in Research Laboratories particularly in

Biochemistry,Clinical Chemistry, or in related fields.

EDUCATION:

Ph.D. Biochemistry

WORK EXPERIENCE

2009-Pres Research Associate, Dept of Biology.Howard University,

Washington DC.

2006-2009 Research Associate, Dept of Oncology. Georgetown

University. Washington D.C.

2001-2006 Post Doctoral Fellow. Heritable Disorder Branch. NICHD,NIH

TECHNICAL EXPERTSE

Nucleic Acid Based Assay and Microarray Technology

. Isolation and Purification of DNA and RNA, cDNA synthesis.

. qRT-PCR and Taqman Low Density Array

. Gene Expression Array

Molecular Biology

. Engineering of different tag construct and fusion protein.

. Gene cloning and expression.

. Radiolebelling in vitro and in vivo.

Bioinformatics

. Statistical Analysis of Microarray Results : Partek GS. Genespring

GX, RQ manager, Dataassit,IPA.

. Sequence analysis tools. Bioedit,

. Functional analysis Tools. Polyphen, SIFT, SNP3D, Motif Scan, Net

phos

Cell biology

. Cross linking and co-immuno precipitation

. Immunocytochemistry

. Cell based assay.

Immuno Diagnostics and Assay Development

. In house reagents preparation and study Design

. Standardization for RIA IRMA and ELISA.

. Validation and Quality control

Protein Chemistry

. Protein Purification and Characterization. Western and Dot Blot.

. Enzyme kinetics including pre steady state.

. Protein Modification and Cross linking.

Others

. To assist Supervisor for reviewing of papers and research grant.

. Laboratory management and supervision of summer and graduate

students.

Special Trainings:

Course on 'Principles of Clinical Pharmacology' conducted by The Warren

Grants Magnuson Clinical Center at National Institute of Health (Sept

2, 2004 to Apr 28, 2005)

Training course on 'Recombinant DNA Methodology I' conducted by The

Foundation for Advanced Education in the Sciences, Inc. at the National

Institute of Health (Sept 13 to Dec 06, 2001)

Workshop on Monoclonal Antibody, organized by Association of Clinical

Biochemist of India (10-11th Dec 1997)

National Training Program on Radioimmunoassay for Young Scientists by

Indian Council of Medical Research (IPGME & R, Calcutta). (5-10th Jan

1987)

PUBLICATION

1. Mitra PS, Basu NK, Basu M, Chakraborty S, Saha T, Owens IS Regulated

phosphorylation of a major UDP-glucuronosyltransferase isozyme by

tyrosine kinases dictates endogenous substrate-selection for

detoxification..J Biol Chem. 2010 Nov 5. [Epub ahead of print]

2. Mitra P.S, Basu NK, Owens IS. Src supports

UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens

associated with breast cancer. Biochem Biophys Res Commun. 2009 Mar 14.

3. Basu NK, Kole L, Basu M, Chakraborty K, Mitra P.S, Owens IS.The

major chemical-detoxifying system of UDP-glucuronosyltransferases

requires regulated phosphorylation supported by protein kinase C. J

Biol Chem. 2008 Aug 22;283(34):23048-61.

4. Adhikari S, Kennel SJ, Roy G, Mitra P.S, Mitra S, Roy R.

Discrimination of lesion removal of N-methylpurine-DNA glycosylase

revealed by a potent neutralizing monoclonal antibody. DNA Repair

(Amst). 2008 Jan 1;7(1):31-9.

5. Adhikari S, Choudhury S, Mitra P.S, Dubash,J. J., Sajankil. S., Roy

R. Targeting Base Excision Repair for Chemosensitization. Accepted in

Anti Cancer Agents in Medicinal Chemistry. (2008) May;8 (4):351-7.

Review.

6. Basu, N.K., Kovarova M, Garza A, Kubota S, Saha T, Mitra, P.S,

Banerjee R, Rivera J, and Owens, I, S., Phosphorylation of a

UDP-glucuronosyltransferases regulates substrate specificity. Proc Natl

Acad Sci USA 2005 May 3 ;102(18):6285-6290.

7. Basu, N.K., Ciotti, M., Huang, M.S., Kole, L., Mitra, P.S., Cho,

J.W., and Owens, I.S. Differential and special properties of the major

human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases

enhance potential to control chemical uptake. J Biol. Chem., 279(2),

1429-41, 2004.

8. Hati, R.N., Mitra, P.S., Starker S., Bhattacharya K.K. Snake Venom

Hemorrhagins. Critical Reviews in Toxicology 29(1), 1-19, 1999.

PRESENTATION

1. Partha S Mitra, Somiranjan Ghosh, Shizhu Zang, Dean Sonneborn, Irva

Hertz-Picciotto, Tomas Trnovec, Lubica Palkovicova, Eva Sovcikova,

Svetlana Ghimbovschi Eric Hoffman, Sisir Dutta. Persistent Organic

Pollutants (POP) and their Effect on Gene Expression in Exposed

Children ISES-ISEE 2010 (Abstracts No. 1467)

2. Sisir K Dutta, Partha S Mitra, Somiranjan Ghosh, Shizhu Zang, Dean

Sonneborn, Irva Hertz-Picciotto, Tomas Trnovec, Lubica Palkovicova,

Eva Sovcikova3, Svetlana Ghimbovschi, Eric P. Hoffman Gene Expression

Analysis of PCB exposed Children: Understanding Toxicity and Disease

Process. ISES-ISEE 2010 (Abstracts No. 1460)

3. Mitra,P S. Ghosh,S.,Dutta,S.K. Compexity and Challenges to

establish the disease Biomarkers for PCB Exposed Human population.

Accelerating Development and personalized therapy(ADAPT)

Congress.Washington,D.C. Dec.22-25,2009.

4. Nikhil Kumar Basu, Partha S Mitra, Amanda Garza, Mousumi Basu, Rajat

Banerjee and Ida S Owens. Understanding How Phoshorylation of the

UDP-Glucuronosyltransferase System Controls and Protects Against

Chemical Toxins. The FASEB Journal. 2007;21:807.13.

5. Mitra,P.S., Basu,N.K., and Owens,I,S., UGT2B7 requires

phosphorylation for activity ( Poster Presentation.) Abstract Number:

1289 THE FASEB JOURNAL 18 (2004) pp C73.

6. Basu,N.K., Kole,L..,Mitra,P.S.,and Owens,I,S., Phosphorylation of

UDP-glucuronosyl transferases (UGT1A1) is require for activity and

involves Protein Kinase C Selected for Oral and Poster Presentation.

THE FASEB JOURNAL 17 (2003) pp A1308

7. Sarker, S., Mitra P.S., Bhattacharyya K.K., and Hati, R.N. (1990)

Action of venom protease and hemorrhage in Russell's viper

envenomation. (Presented at 86th INDIAN SCIENCE CONGRESS, 1-3rd Jan

1999, Chennai, India).

8. Mitra, P.S., Sarker, S., Bhattacharyya, K.K., and Hati,R.N. (1999)

The hemorrhage due to the Russell's viper bite and the role of

metalloprotease. Proceedings of 6th West Bengal State Science and

Technology Congress, Calcutta, India, February 26 to 28, 1999.

Partha S Mitra

December 22nd, 2010

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