Supply Chain Project

A mina Ferraz – Curr iculum Vitae

Amina FERRAZ

M Pha rm, PhD

* ********** ********, **** **** 8JL

Tel: +44 (0-758*******

D.o.B: 13 September 1980

Nationality: Bri tish

*****.******@*****.***

Education

Doctorate

Oct 2003 – Sep 2007: Ph.D. in Pharmaceutical Science (Pulmonary Drug Delivery)

The School of Pharmacy, University of London in collaboration

w ith AstraZeneca, UK

Project: To produce a stable system in pMD I aerosol

p ropellants, which forms a drug carrier upon delivery from

t he device. M ixed solvent systems in HFA aerosol

p ropellants, containing dissolved carrier-forming materials,

such as phosphatidylcholines and non-ionic surfactants,

were prepared. Both hydrophilic and hydrophobic drugs

were incorporated in to these solvent systems and

i nvestigated. A novel time release profile was achieved.

Master of Philosophy

Oct 2003 – Oct 2004: MPhil in Pharmaceutical Science

The School of Pharmacy, University of London

Master of Pha rmacy

Oct 1999 – Jun 2003: Pharmacy, MPharm (Hons) (2.1)

The School of Pharmacy, University of London

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A mina Ferraz – Curr iculum Vitae

Computer skills: Diploma in Computer Li teracy & Information Technology Stage I

& a qualification in In tegral Business Technology Stage I I, 1998.

E xperienced user of MS Office, MS Visio, MS Project.

Computer skills: polyglot: English, French, Spanish, Arabic.

Work experience

Feb 2007 – Dec 2010: Pfizer Inc, U K

Role: Senior Inhalation Formulation Scientist

Formulation Lead for novel drug candidates to First-in-Human (FIH) projects in the Research

I nhalation team, specifically delivering dry powder formulations suitable for use in the FI H

s tudy for each compound . Formulation lead for development compounds, namely responsible

for formulation development of dry powder inhaler products undergoing late stage

clinical t r ials and for dose selection and bridging in vivo and in vitro studies, as well as

engaging with various stakeholders to enable efficient and t imely delivery of the project goals

and proactively advising line management and Pharm Sciences Team Leaders to facilitate the

development of quality formulations. Other responsibilities include coordinating clinical t r ials,

collecting inhalation profiles from healthy volunteers and patients and carrying out clinically-

focused formulation development using the Breathing Simulator and the Inhalation Profile

Recorder.

Leadership roles

– Formulation Process Improvement Lead, responsible for pursuing continuous

CAN to FI H formulation process improvement through the integration of formulation and

p rocess development, accomplish ‘fit for purpose’ product performance in as lit t le time as

possible.

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A mina Ferraz – Curr iculum Vitae

– Co-lead for a Supply Chain – Research Inhalation collaboration, responsible for

mapping the CAN to FIH multidisciplinary process in order to identify a strategic plan to

reduce t imeline and improve organisational performance.

– Co-lead for an internal B lending Technology Focus Group.

– Lead for an internal Biopharmaceutics Technology Focus Group.

Supervisory roles

– Supervisor for a few industrial t rainees, Pre-Registration pharmacists and

summer students.

Courses and t raining

Training courses include cGMP, COSHH, DSEAR, r isk assessment, hazardous process

containment, and various personal skills development.

Technical skills and personal att r ibutes

Clinical pharmacy background; Pressure filling & cold filling of pressurised systems, including

solubili ty evaluation of pMDI formulations; Blending and filling of dry powder inhaled dosage

forms; Microscopy: L M, TEM, SEM & Photomicrography; Spectroscopy: PCS, UV, NMR, IR &

M S; Single-Stage L iquid Impinger, Mul ti-Stage Liquid Impinger, Anderson Cascade Impactor

& Next Generation Impactor i n-vitro studies; Chromatography: HPLC, TLC, Flash column

chromatography; Empower user; Turbiscan, APS & Spraytec; Controlled release

measurement; Collection of inhalation profiles using the Inhalation Profile Recorder (IPR);

I nvestigate the promise of novel formulations in terms of clinically-relevant parameters

t hrough analysis on the Breathing Simulator using real inhalation profiles as well as

comparing various marketed products; Design and undertake a research project for both

p ressurised and dry powder inhalers; Design and undertake scientific experimentation to

f ur ther the formulation development and manufacturing process of dry powder inhalers for

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A mina Ferraz – Curr iculum Vitae

novel drug candidates, including analytical activities; Define manufacturing processes and

p rovide scientific support to the GMP manufacture of clinical supplies and provide assistance

i n scale-up and technology t ransfer to the Supply Chain group; L i terature searching strategies

and use of statistical tools in research; Effective time management and team working;

I ndependence, productivity and innovation in own work; Planning, prioritisation and

i nterpretation of own research findings; Appropriate wri ting and presentation skills and

effective communication with colleagues within Pharm Sciences and the candidate

m ultidisciplinary teams; supervision and coaching of direct reports within the team.

Awards

– UL LA (European University Consortium for Pharmaceutical Research) Best Poster &

P resentation Award (Uppsala, Sweden), 2005;

– Best MPharm Fourth Year Pharmaceutics Paper Award (UK), 2003;

– Best MPharm Third Year Project Award (UK), 2002;

– First National result in the Baccalaureate Exam Full Scholarship Award (Algeria),

1997 to 2006;

– BP (Bri tish Petroleum) Scholarship Award (UK), 1998;

– Sonatrach Scholarship Award (Algeria/UK), 1997.

I n terests

– World Travel and experiencing different cultures and customs;

– Sports, chess, gardening, voluntary work at local cancer research charities.

Articles/Publications

– Alouache, A.I., Kellaway, I.W., Taylor, K.M.G. Novel Controlled-Release Colloids

Generated From Salbutamol Base and Budesonide Pressurised Metered Dose Inhaler Solution

Formulations. I n publication.

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A mina Ferraz – Curr iculum Vitae

– Alouache, A.I., Kellaway, I.W., Taylor, K.M.G., Rogueda, P. Assessment of Spray

Performance and Stability Kinetics of HFA 134a Suspensions Prepared with 1H,1H,2H,2H-

Perfluorooctan-1-ol and PEG-Phospholipids. I n publication.

– Alouache, A.I., Kellaway, I.W., Taylor, K.M.G., Rogueda, P., (2006). Effect of

F luoroalcohol on Product Performance in PEG-Phospholipid-Containing Pressurised Metered Dose

I nhalers. Journal of Aerosol Medicine, 20: 372.

– Alouache, A.I., Kellaway, I.W., Taylor, K.M.G., Rogueda, P., (2006). Stability

K inetics of HFA Suspensions Prepared with a Fluoroalcohol and PEG-Phospholipids. Journal of Aerosol

Medicine, 20: 373.

– Alouache, A.I., Kellaway, I.W., Taylor, K.M.G., Rogueda, P., (2006). Controlled-

Release Colloids Generated From Budesonide Pressurised Metered Dose Inhaler Solution

Formulations. Journal of Aerosol Medicine, 20: 372.

– Alouache, A.I., Kellaway, I.W. & Taylor, K.M.G. (2006) Pressurised Metered Dose

I nhaler Solution Formulations To Generate Controlled Release Colloids. In: Dalby, R.N., Byron, P.R.,

Peart, J., Suman, J.D. and Farr, S.J., (Eds), Respiratory Drug Delivery X . Interpharm Press, Buffalo

G rove, I L.

Conferences

– May 2009: Respiratory Drug Delivery Europe (RDD Europe), Lisbon, Portugal.

– Dec 2008: Drug Delivery to the Lung (DDL) 19, Edinburgh, UK.

– Dec 2007: Drug Delivery to the Lung (DDL) 18 in Edinburgh, UK.

– Nov-Dec 2006: Drug Delivery to the Lung (DDL) 17 in Edinburgh, UK. Three

poster presentations & three abstract submissions.

– Apr 2006: Respiratory Drug Delivery (RDD) X in Boca Raton, Florida, US.

Poster presentation & abstract submission.

– Jul 2005: UL LA European University Consortium for Pharmaceutical

Research Symposium at Uppsala, Sweden. Poster presentation.

References

Provided as requested.

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