Project Manager
Resume:
CURRICULUM VITAE
Michelle Elaine Fonda
Meadow Vista, CA 95722
**************@****.***
EDUCATION
University of California, Riverside, 1979, B. Sc. Biology
California State University, Sacramento, 1980, Public Health Microbiology
Courses
University of California, Berkeley, 1983, Molecular Biology Course
Project Management Courses at Novo Nordisk
Managing Projects Successfully with Microsoft Project Desktop at Abraxis
BioScience
PROFESSIONAL EXPERIENCE
10/03 to Present Microbiology Research Manager, Abraxis
BioScience, Auburn, CA. As Team Leader coordinates
and manages the activities of the Auburn Natural
Products Drug Discovery Group to maintain project
timelines. With input from the group, prioritizes
candidates for most efficient use of time and manages
the advancement of lead candidates. Coordinates the
efforts of microbiology and chemistry to efficiently
move the projects forward in order to quickly
identify lead structures. Facilitates open
communication and exchange of information between
groups. Primary responsibility is innovative strain
isolations from globally diverse soil collection.
Personally responsible for primary isolation and
selection of actinomycetes and bacteria. Directs
fungal isolations by a Research Associate.
Fermentation optimization/production for lead hit
strains to produce sufficient quantities for
structure elucidation and early MOA/clinical studies.
Maintains the company culture collection via
cryopreservation and database entry.
9/94 - 9/03 Microbiology Research Manager. Interlink
Biotechnologies, LLC., Auburn, CA.. Project and team
leader of a group of microbiologists who are
responsible for the isolation and characterization of
novel microorganisms to be used to produce unusual
secondary metabolites, enzymes, etc. Plan, administer
and coordinate projects to maintain efficient
throughput of activities while maintaining an
orientation towards achievement of set goals and
milestones. Communicate information via oral
presentations and written reports to clients and
members of the research team. Involvement with a
highly integrated research team which includes
microbiology, microbial genetics, microbial
physiology, metabolic biochemistry, protein
biochemistry, molecular biology, natural products
and analytical chemistry. Development of unique
microbial isolation techniques based on clients'
requirements. Optimization of fermentation conditions
for the production of metabolites and enzymes.
Development and implementation of protocols and
procedures for the analysis of biologically active
peptides against a panel of medically important
microorganisms including strains associated with
bioterrorism. Organize and maintain the company
culture collection. Participate in trade exhibits
and poster presentations at scientific conferences.
Responsible for establishing safety protocols and
procedures in order to meet local and federal
compliance requirements.
11/91 - 6/94 Staff Researcher. Novo Nordisk Entotech,
Inc., Davis, CA. Member of the
Discovery team whose purpose was to identify
microorganisms that produce novel biopesticides.
Researched and developed new isolation, screening and
fermentation techniques. Designed and executed GLP
protocols and procedures to support the registration
of a new biopesticide product. Organized company
culture collection. U.S. representative for Novo
Nordisk International Culture Collection. Member of
the Safety Team.
8/87 - 10/91 Senior Research Associate. Ecogen, Inc.,
Langhorne, PA. Functioned as the
Assistant Team Leader for the Biofungicide Project.
Isolated, assayed, and characterized microorganisms
that exhibited antifungal activity. Developed in
vitro and in planta screening procedures to assess
the potential efficacy of the organisms. Examined
the ecological parameters that might influence the
performance of the organism. Designed gel
electrophoresis techniques to monitor the ability of
the organism to colonize roots in growth chamber and
field tests. Aided in the fermentation and
formulation of Dagger G; the biofungicide effective
against the cotton plant pathogens, Pythium and
Rhizoctonia species. Instrumental in obtaining EPA
registration for Dagger G. Organized the culture
collection for the project. Member of the Safety
Team.
1/87 - 7/87 Culture Curator/Research Assistant. Genentech,
Inc., South San
Francisco, CA. Organized and instituted the Company
Culture Collection. Preserved and verified
recombinant strains. Developed the computer database
and retrieval system for the depository.
6/85 - 12/86 Associate Research Biologist. Stauffer
Chemical
Company,
Richmond, CA.
Member of the Fermentation Department. Conducted the
project in which the goal was to produce a functional
fermented product for use as a food ingredient.
Natural substrates were used in these novel
fermentations. Organized and was responsible for the
Company Culture Collection in which recombinants,
bacteria, fungi, algae, actinomycetes, plant cells,
and yeasts were preserved. Worked on plant-pathogen
interactions in the agronomic group. Designed and
taught an on-site educational program for local high
school students. Member of the Safety Team.
7/84 - 5/85 Research Associate. Salk Institute of
Biotechnology, Inc., Assoc., La Jolla, CA.
Member of the fermentation group. Research and
development of new techniques to
increase expression in recombinant yeasts.
Experience in fermentor assembly and
function. Organized and instituted the Company
culture Collection including policy
formation, culture verification, handling of patent
deposits, and computer database
retrieval.
6/81 - 7/84 Research Assistant. Cetus Corporation,
Emeryville, CA. Member of an
innovative research team studying natural product
formation by microorganisms. Research and development
of novel isolation, screening, assay, and
fermentation techniques in order to discover new
microbial sources of enzymes used in the production
of commodity and specialty chemicals. Expertise in
the isolation, taxonomy, physiology, and ecology of
algae, bacteria, actinomycetes, and fungi. Experience
in recombinant DNA techniques including plasmid DNA
isolation, verification, and cloning. Designed
experiments involving plant-pathogen interactions
with respect to specific enzyme systems. Other
duties included preservation of cultures,
characterization of industrial and scientifically
important strains, and training and supervision of
technical staff. Analytical work involved use of gel
electrophoresis, gas chromatography,
spectrophotometric assays, and radioisotope
techniques.
3/81 - 6/81 Laboratory Technician. Morse Analytical Lab,
Sacramento, CA. Analyzed food and agricultural
products to determine the protein, fat, carbohydrate,
and water content.
3/76 - 6/78 Laboratory Assistant. University of California,
Riverside. Maintenance and
preservation of bacteria, recombinants, and virus.
Preparation of media, cultures, and laboratories for
microbiology, medical microbiology, and genetics
courses.
PROFESSIONAL & SCIENTIFIC ORGANIZATIONS
Society of Industrial Microbiology
PUBLICATIONS & PRESENTATIONS
1. Everett, N. P., M. E. Fonda, Brown, M. P., Clark, S.,
Fortier, H., Gennity, I., Kirkbride, R., Kumar, P., Loser, K.
S.,
and Woldermariam, T.. Metabolite and Protein Profiling of
Microbial Genetic Diversity. 7th International Antibacterial
Drug Discovery and Development Summit, Princeton, New
Jersey, U.S.A., March 11-12, 2002.
2. Everett, N. P., M. E. Fonda and Brown, M. P.. The continually
evolving role of microbial diversity in commercial R&D.
Sixth International Conference on the Biotechnology of
Microbial Products: Pharmacological and Agrobiological Activities.
San Diego, California, U.S.A., May 16-19, 1999.
3. Hunter-Cevera, J. C., M. E. Fonda, R. Toso, S. L. Neidleman. Screening
for Unique Haloperoxidases from Marine Sources. 1991. International
Marine Biotechnology Conference. Baltimore, Maryland.
4. Hunter-Cevera, J. C., M. E. Fonda, R. Toso, T. M'Timkulu and K. Watt.
Production of Haloperoxidases by Marine Bacilli. American Society of
Microbiology. 1989. New Orleans, LA.
5. Hunter, J. C., M. E. Fonda, L. Sotos, and A. Belt. Fungal
Chloroperoxidase Method. Patent # 4,707,447, 1987.
6. Hunter, J. C., M. E. Fonda, L. Sotos, R. Toso, A. Belt. Ecological
Approaches to Isolation. Developments in
Industrial Microbiology. 1984, Volume 25.
7. Hunter, J. C., M. E. Fonda, and A. Belt. Isolation of Cultures.
Manual of Industrial Microbiology and
Technology. 1985.
7. Hunter, J. C., M. E. Fonda, A. Belt, J. Geigert, and N. Gerber. A Novel
Nitrogen Fixing, Prodigiosin Producing,
Wax Ester Forming Bacterium. International Microbial Ecology
Meeting. August 7 - 12, 1983. East Lansing, MI.
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