Manager Development
Resume:
CURRICULUM VITAE
Dr.Devendra Narayanrao Ridhurkar
M.Pharm., Ph.D. (P'ceutics)
Flat No 101, Jyoti Pearl Apartment,
Srinivas Nagar Colony, Dr.A.S. Rao Nagar
Kapra, Hyderabad (A.P), India
Contact No.080********, 093********
E-mail: *******@*****.**.**
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Career Objective:
To become an essential intellectual asset to the company, by contributing
my proficiency comprehension and management skills.
About Me:
An upbeat, self-assured and ambitious young man. Assertive in nature,
clarity in thoughts with strongly inquisitive and research oriented mind.
Excellent outlook to work in a group having problem solving approach in
work and ability to plan and implement novel ideas. Well informed and can
put forth my ideas and arguments very lucidly and succinctly and having
excellent theoretical background with a good practical hand. Ambition in
life is to reach the heights in the field I am working, for which
prerequisites would be, honesty, hardworking and determination to success.
Personal Profile:
Name : Devendra N.Ridhurkar
Father's Name : Narayanrao M. Ridhurkar
Mother's Name : Maltitai N.
Ridhurkar
Present address : Devendra N. Ridhurkar
Flat No 101, Jyoti Pearl Apartment,
Srinivas Nagar Colony, Dr.A.S. Rao Nagar
Kapra, Hyderabad (A.P), India
*****************@*****.***
Date of Birth : 22nd November1977
Sex : Male
Nationality : Indian
Languages known : Hindi, English, Marathi and French
Marital status : Married
Educational Qualification:
Sr.N Exam Passed Board/University Year of % of Marks/
o. Passing CGPA
1 Ph.D.(Pharmaceutics) I.T.,B.H.U., Varanasi June 2007 Degree
awarded
2 M.Pharm.(Pharmaceutics I.T.,B.H.U., Varanasi May 2003 7.89 (CGPA)
)
3 B.Pharm Nagpur University July 2001 60.10
4 D.Pharm. B.T.E. Mumbai June 1997 60.10
5 S.S.C. Nagpur April 1993 68.0
6 Diploma in French B.H.U., Varanasi April 2007 57.2
Research Interests:
> Formulation and development of oral solid, Parenteral and liquid drug
delivery systems.
> Extended, modified and controlled drug delivery system.
> NDDS and targeted drug delivery systems.
> Pharmacokinetics and Bioavailability studies.
> Intellectual Property Rights (IPR), ANDA, formulation and development
of NCE and NDA for regulatory markets.
Projects:
Title of M.Pharm Dissertation:
"Formulation, characterization and in-vitro evaluation of floating
microspheres of cimetidine"under A .K.Srivastava, Department of
Pharmaceutics, I.T., B.H.U, Varanasi.(Abstract attached - Annexure I)
Title of Ph.D. Thesis:
"Hydrophilic swellable polymer based gastric floating systems for oral
controlled delivery of cinnarizine hydrochloride" under Prof J.K.Pandit,
Department of Pharmaceutics, I.T.B.H.U.,Varanasi. (Abstract attached -
Annexure II)
Present Position:
Working as Deputy Manager in Center of Excellence (Formulation and
Technology) Dr. Reddy's Laboratories, Hyderabad from December 2010 to till
date.
Membership in Professional Bodies:
Life member of Indian Pharmaceutical Graduate Association (IPGA).
Extracurricular Activities and Hobbies:
o Played Cricket and volleyball at College level.
o Volunteer for organizing "PTFD-2004"Pharmaceutical conference
organized by Society of department of Pharmaceutics held at BHU-
2004".
o Swimming, traveling and reading tabloids.
Working Experience:
Total working experience -5.0 years.
A) Presently Working as a Deputy Manager in Center of Excellence
(Formulation and Technology Dr. Reddy's Laboratories, Hyderabad from
December 2010 to till date.
Handling NDA and Platform Technology based Projects for US/EU Market like
lyophilisation, nanotechnology, cyclodextrin complexation and hot melt
extrudation.
B) Worked as an Assistant Manager in formulation and development department
in IPCA Laboratories, Mumbai in Formulation and Development division from
July 2009 to November 2010.
*successfully completed projects while working with IPCA Laboratories.
Handling sustained release and extended release projects based on
Reservoir, Matrix and MUPS Technology to be developed for US and Europe
Market like.
1. Development of extended release tablets based on matrix approach for
higher dose BCS class I drug used as oral antihyperglycemic
agent.(With PARA-IV Approach)
2. Development of extended release tablets based on Floating Bilayer and
monolithic matrix approach for class -I molecule which is light and
moisture sensitive. Also the molecule is having stomach specific
absorption and used in the treatment of benign prostate hyperplasia
(with PARA-IV Approach).
3. Development of extended release tablets for 24 hours, based on
Reservoir approach for class-I molecule generally used as an
antidepressant. (With PARA-IV Approach).
4. Development of sustained release tablets for 12 hours, based on Matrix
approach for highly unstable molecule generally used as an
antidepressant and seasonal affective disorder. (With PARA-III
Approach).
5. Development of extended release tablets for 24 hours, based on Matrix
approach for class II molecule generally used as an anti-inflammatory
(With PARA-III Approach).
6. Development of extended release tablets for 24 hours based on
Reservoir approach for class I molecule generally used as an anti-
inflammatory/analgesic using water insoluble polymers like ethyl
cellulose. (With PARA-III Approach).
7. Development of trilayer, bilayer tablets for combination of Sustained
and Immediate release layers containing 3-4 drugs using various
solubilising techniques to solubilise the class II and IV drugs
present in formulation.
C) Worked as a Research Scientist with Macleods Research Center, Andheri,
Mumbai in Formulation and Development division from June 2007 to July 2009.
*successfully completed projects while working with Macleods Research
Center.
1. Extended release tablets for BCS class I Drugs like beta blockers.
2. Sustained release capsules for poorly soluble drugs having dosage in
microgram used for benign prostate hyperplasia.
3. Developed delayed release tablets for acid sensitive proton pump
inhibitor used as an antiulcer agent for ANDA filing with
noninfringement strategy.
4. Recently filled two patent applications for Development of D.R.
Tablets for acid sensitive drug like PPI and extended release bilayer
tablet containing antipyretic drugs.
5. Two pilot bioequivalence for ANDA (with PARA-IV approach) was conceded
for two of my project handling in Macleods.
a) For delayed release tablets of acid sensitive Benzimidazole
derivative used as a proton pump inhibitor using enteric coated
polymer like Eudragit.
b) For film coated IR tablets for drug used for Alzheimer disease.
6. Knowledge about international GMP guidelines and experience in
a GMP environment in
Pharmaceutical sector.
C) Worked as a Principal for 3 months at IDIOP Digras, Maharashtra during
February 2004 to May 2004.
D) Worked as an R&D officer in F&D division in Indchemie (Alkem group) for
8 months at Daman during May 2003 to December 2003.
*successfully completed projects while working with Indchemie (Alkem group)
1) Development of antiviral drugs (Saquinavir and Lopinavir) and
2) Antiallergics and Antitussives in soft gelatin during working with
Indchemie.
Practical Skills:
< Formulation of novel drug delivery systems, formulation and
development of soft gelatin capsules and tablets.
< Sound knowledge of development of formulation for regulatory market
like USA, Europe, Japan and Australia, Intellectual Property Rights
(IPR),
< Sound knowledge of Quality by design and Design of experiment.
< Documentation and validation of formulations prepared on pilot plant
and commercial scale.
< Stability studies according to ICH guidelines.
< Handling of instruments viz.U.V. Spectrophotometer, HPLC, and
fluorometer and also having exposure to XRD, NMR, DSC, SEM and FT-IR
during M.Pharm.and Ph.D. projects.
< Handled critical projects like benzimidazole and statin derivatives,
and successfully developed the formulations up to Exhibit batch for
US/EU with Para IV filling.
< Knowledge about SOP,cGMP,SUPCA-IR/MR and instrument qualifications.
< Documentations required for scale up like MMF, Process optimizations
report, patent write up, and ANDA filling like product development
report as per CTD format
Awards and achievements:
* Recipient of Suresh Kare Indoco foundation scholarship from December
2004 to June 2005 and University Grant Commission, New Delhi granted
Junior Research Fellowship (JRF) for Ph.D. from July 2005 till June
2006. Banaras Hindu University granted Senior Research Fellowship
(SRF) for Ph.D. from July 2006 up to June 2007.
Publications:
a) Published: International -4, National-1 b) Under Review: 1 c)
International and National Conferences: 9 and patent application-2 ((List
attached - annexure III)
Computer literacy:
Windows, M.S. word, Microsoft excel, Power Point, Outlook express, Sigma
plot -5 and origin-6
Reference:
Prof.J.K.Pandit
Professor of Pharmaceutics
Department of Pharmaceutics, I.T.,B.H.U.Varanasi - 221 005
Tel.: (054*-*******, 49 (O) 098********
Declaration:
I here by declare that the information furnished above is true to the
best of my knowledge.
Date: / /2011
Place: Hyderabad
Dr.Devendra N. Ridhurkar
ANNEXURE-I
M.Pharm Project: Formulation, characterization and in-vitro evaluation of
floating microspheres of cimetidine.
Project Abstract: The present study involves preparation and evaluation of
floating microspheres of cimetidine for prolongation of gastric residence
time. Cimetidine is a H2 receptor antagonist having an antiulcer activity.
The choice of cimetidine is because of its poor absorption in lower
gastrointestinal tract; short half life and pH dependent solubility. The
microspheres were prepared by the solvent evaporation method using polymers
hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface
morphology of prepared microspheres were characterized by optical and
scanning electron microscopy, respectively. In vitro drug release studies
were performed and drug release kinetics was evaluated using the linear
regression method. The prepared microspheres exhibited prolonged drug
release (8 h) and remained buoyant for > 10 h. In vitro studies
demonstrated diffusion-controlled drug release from the microspheres.It is
also observed that there is decrease in release in pH 7.4 as compared to
pH1.2.
ANNEXURE-II
Ph.D. Project: Hydrophilic swellable polymer based gastric floating systems
for oral Controlled delivery of Cinnarizine
hydrochloride.
Project Abstract:
The present work is designed to develop monolithic and bilayer
floating matrix tablets of Cinnarizine HCl, which on oral administration
would be retained in gastric environment for prolonged times and thereby
increase its bioavailability and diminished side effects. Cinnarizine HCl
has a half-life of 3- 6 hr, pH dependent solubility and is better absorbed
in the upper part of gastrointestinal tract (Martindale 1993).
The major objectives of the present work were I) To develop a single unit
and bilayer gastroretentive drug delivery system employing swellable
polymers. II) To find out the relationship of swelling, erosion properties
of hydrophilic polymers with kinetics, mechanism of drug release and
floating behavior. III) In vivo evaluation of pharmacokinetics properties
(Bioavailability study) on animals.
Matrix tablets were comprised of an active ingredient, 0-80% by weight
inert materials and 20-75% by weight of one or more polymers along with
tablet excipients. All fabricated systems were evaluated for hardness,
thickness, drug content uniformity, friability, density of tablets,
resultant weight kinetics, swelling kinetics, measurement of matrix erosion
and in-vitro drug release. Compatibility study was performed on DSC and FT-
IR in order to find out drug -excipients interaction. Stability studies
were also conducted for selected formulations at room temp (27 10C) and at
50 10C for a period of 6 months. Selected formulation was also evaluated
for in vivo bioequivalence study on animals.
ANNEXURE -III
Publications:
A) Patent applications-
1) D.N.Ridhurkar, Rajendra Agarwal and Hitesh Maheshwari, Application no-
534/MUM/2009, "Extended Release Formulation Of Cyclobenzaprine".
2) D.N.Ridhurkar, Rajendra Agarwal and Hitesh Maheshwari, Application no-
2741/MUM/2008, "Paracetamol Extended Release Tablet Formulation".
B) Research papers published in international journals.
1) D. N.Ridhurkar, R. Nagarwal and J.K.Pandit "In-vitro Release Kinetics
and Bioavailability of Gastroretentive Cinnarizine Hydrochloride
Tablet".AAPS PharmSciTech, Vol.II, No.1, 294-303, 2010.
2) D.N. Ridhurkar, J. K. Pandit, Romi Barat, Neelam Mittal, D. N. Mishra,
A. Srinatha and J. Balasubramaniam "Niridazole biodegradable inserts
for local long-term treatment of periodontitis: possible new life for
an orphan drug". Drug Delivery, 13:365-373, 2006.
3) D. N. Ridhurkar, A. K. Srivastava and S. Wadhwa. Floating microspheres
of cimetidine: Formulation, characterization and in-vitro evaluation.
Acta Pharm. 55,277-285, 2005.
4) D.N. Ridhurkar, A. K. Srivastava, Saurabh Wadhwa and B. Mishra "Oral
sustained delivery of atenolol from floating matrix tablets-
formulation and in-vitro evaluation". Drug Dev. Ind. Pharm.31, 377-
384, 2005.
C) Research papers published in national journals.
1) D.N. Ridhurkar, J.K.Pandit, D Bharathi, A Srinatha and S. Singh "Long
acting ophthalmic formulation of indomethacin: Evaluation of alginate
gel systems". Indian Journal Of Pharmaceutical Sciences 69(1), 37-40,
2007.
Papers Abstracted in Congress/Seminars/Symposia
1. D. N. Ridhurkar and J. K. Pandit, "Swellable polymer based
gastroretentive matrix tablets of cinnarizine HCL: relationship
between swelling, erosion, floating and in-vitro drug release". 59th
IPC, BHU, Varanasi, December 2007.
2. D. N. Ridhurkar, A.Srinatha, R.Nagarwal, and J. K. Pandit.
"Gastroretentive insitu gelling systems of metformine: A novel
platform for redesigning liquid formulations". 58th IPC, Mumbai,
December 2006.
3. D. N. Ridhurkar, M.Thilek Kumar and J. K. Pandit. "Gastroretentive
insitu gelling systems of amoxicillin". 57th IPC, Hyderabad, December
2005.
4. D. N. Ridhurkar, M.Thilek Kumar, A.Srinatha, R.Nagarwal, M.K.Senapati
and J. K. Pandit. "Formulation and invitro evaluation of matrix
tablets containing natural polysaccharides as release modulators".
57th IPC, Hyderabad, December 2005.
5. D. N. Ridhurkar, M.Thilek Kumar, A.Srinatha, S.Chakraborty,
M.K.Senapati and J.K.Pandit "Amoxicillin -Gellan gum based matrix
tablets: Fabrication and in-vitro evaluation". 56th IPC, Kolkatta,
December 2004.
6. D.N.Ridhurkar, M.Thilek Kumar, A.Srinatha, S.Chakraborty, M.K.Senapati
and J.K.Pandit "In situ gelling system of amoxicillin for sustained
delivery". 56th IPC, Kolkatta, December 2004.
7. D.N.Ridhurkar, S.Kaushik, A.K. Srivastava, S. Wadhwa, and B.Mishra.
"Swelling modulated osmotically controlled oral drug delivery systems
of Diltiazem Hydrochloride: development and evaluation". 56th IPC,
Kolkatta, December 2004.
8. D. N. Ridhurkar, A.K. Srivastava, J. Singh, S.Singh, S. Wadhwa and
B.Mishra. "Floating microspheres of cimetidine: Formulation,
characterization and invitro evaluation". 56th IPC, Kolkatta, December
2004.
9. D.N.Ridhurkar, M.Thilek Kumar, A.Srinatha, S.Chakraborty, M.K.Senapati
and J.K.Pandit "Floating beads of Amoxicillin for prolonged oral
delivery". 56th IPC, Kolkatta, December 2004.
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