Quality Control Assistant
Resume:
Professional Profile
Sampada A Khanapurkar
Address: *** ********* ** # * ****** MA 01801 Phone: 540-***-****
Email: **********@*****.***
Objective
To acquire a position in Biotech/Pharma firm with broad-based application of Science and Project
Management.
Technical skill-set
Excellent analytical and communication skills.
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Ability to organize and track complex information.
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Attention to detail and expertise in data acquisition and analysis.
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Effective verbal and written communication.
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Ability to work effectively with cross-functional teams.
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Experience in inventory and supply management.
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Exceptional leadership qualities including training and mentoring.
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Analytical skill-set
Experience in screening small drug candidates using solubility and TSA.
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Training in structure elucidation, isolation and characterization of organic compounds.
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Hands on experience in designing experiments and protocol development using SOPs
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Proficiency in MS Office tools(MS Word, MS Excel, MS Vizio, MS Powerpoint, MS Outlook)
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and Oracle Financials.
Expertise in data analysis and documentation using proprietary software including Masslynx,
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Acquire, ChemStation, RPT, Aspect.
Experience
ArQule Inc. – Scientist III Jul’10 – Present
• Performed quality control and data analysis of kinase screening set.
• Conducted 1D and 2D NMR studies for structure determination of small molecules.
• Initiated the NMR autosampler launch for the department to increase productivity.
• Trained and mentored juniors and interns for system maintenance and instrument
troubleshooting.
• Worked with inter-functional teams to streamline various platform processes.
• Designed and conducted fluorescence experiments for aggregate studies of low solubility
and micelle forming compounds.
• Optimized chemi-luminescence detection studies for solubility measurements.
• Reviewed and analyzed technical documents for various processes conducted in the
laboratory.
ArQule Inc. – Scientist II Mar’08 – Jul’10
• Performed high throughput library purification on kinase drug candidates.
• Provided analytical support for quality control analysis on potential drug candidates in
early discovery processes.
• Performed system maintenance and instrument troubleshooting on Shimadzu and Agilent
HPLC systems, Waters Mass Spectrometer, Leap autosamplers, Bohdan weigher, IQ5
BioRad systems, Gilson injector and collectors.
• Conducted data analysis and documentation using proprietary software like Acquire,
RPT, Aspect.
• Documented SOPs and manuals to support analytical experimentation.
• Maintained data integrity and quality by implementing online data storage and archiving.
Virginia Polytechnic & State University – Research and Teaching Assistant Jan’05 – Aug’07
• Performed bio-assay guided fractionation in isolation of natural products.
• Collected and analyzed samples using HPLC, MS, NMR, IR, and UV-VIS techniques.
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Professional Profile
Sampada A Khanapurkar
Performed data entry and analyzed data using MS Word, MS Office, MS Excel, Cache
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and ChemDraw.
Worked as a Teaching Assistant at undergraduate level chemistry labs.
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Conducted pre-lab lectures on topics related to Organic chemistry, thermodynamics, etc
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Graded lab reports, midterms as well as final exams.
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Wex Technologies – Research Assistant May’03 – June’03
• Performed Acid-Base titrations to evaluate the contents in the water samples.
• Performed data documentation and data archiving.
TDM Labs – Research Trainee Oct’02 – Nov’02
• Analyzed Pharmaceutical Samples using HPLC.
• Monitored bioavailability and bioequivalence of therapeutic drugs to determine the efficacy
and safety of the drug sample.
Education & Certification
Colorado State University, Denver, CO Jan’11 - Present
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o Regulatory Affairs – Professional Certification
o Coursework: IND/NDA/ANDA submission, ICH Guidelines and CTD, FDA, EU and
Canadian Regulations, CMC in drug industry, Pediatric laws and exclusivity, Drug
approval processes, Warning letters, cGMP, Hatch-Waxman amendments
Virginia Polytechnic Institute & State University
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o MS (Organic Chemistry)
University of Mumbai (Bombay), India
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o MS (Inorganic Chemistry)
University of Mumbai (Bombay), India
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o BS (Chemistry)
Chromatography Institute of America
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o HPLC Proficiency Certification
Awards and Affiliations
Received “Team of the Year” award for achieving targets and meeting timelines for delivering
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candidates for H2L and LO projects, 2010 at ArQule Inc.
Received “Reward and Recognition” for devising creative ways to ensure elimination of
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bottlenecks in various processes the platform chemistry, 2009 at ArQule Inc.
Received recognition for completing the screening of AKIP compounds to meet the
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deadlines, 2008 at ArQule Inc.
Received Assistantship for academic performance, 2004-2007
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Received academic scholarship for BS as well as MS Programs for outstanding academic
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performance at the University of Mumbai, India.
American Chemical Society of Pharmacognosy Travel Award at the ACS conference in
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Portland, ME (2007)
Member of the Safety Committee at ArQule, 2009-present
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Member of American Chemical Society, 2005-2008
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Honors
Joint Secretary of Science at Ramnarain Ruia College
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Division Representative at Ramnarain Ruia College
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Event manager for the college festival at Ramnarain Ruia College
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Publications
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Professional Profile
Sampada A Khanapurkar
Mass spectrometric identification and characterization of novel kinase inhibitors that
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preferentially target the auto-inhibited conformation of the protein
Volckova, Erika; Eathiraj, Sudharshan; Nguyen, Khanh; Khanapurkar, Sampada; Hirschi,
Marsha; Ashwell, Mark A. From Abstracts of Papers, 240th ACS National Meeting, Boston,
MA, United States, August 22-26, 2010 (2010), ANYL-135.
Sampada Karkare, Eba Adou, Shugeng Cao, Peggy Brodie, James S. Miller, Fidisoa
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Ratovoson, Rabodo Andriantsiferana, Vincent E. Rasamison, David G. I. Kingston.
Cytotoxic cardenolide glycosides from Madagascar rainforest. J. Nat. Prod., 70 (11),
1766–1770 10.1021/np070336n
Sampada Karkare, Shugeng Cao, Peggy Brodie, James S. Miller, Fidisoa
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Ratovoson, Rabodo Andriantsiferana, Vincent E. Rasamison, David G. I. Kingston.
Antiproliferative triterpenoids from Grewia sp.
Presentations
Sampada Karkare, Shugeng Cao, Peggy Brodie, James S. Miller, Fidisoa
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Ratovoson, Rabodo Andriantsiferana, Vincent E. Rasamison, David G. I. Kingston.
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Cytotoxic cardenolide glycosides from Madagascar rainforest. 48 Annual Meeting of
American Chemical Society of Pharmacognosy, Portland, Maine; July 14-19, 2007.
Sampada Karkare, Dr. Kingston. Anti-cancer agents from Madagascar rainforests. Vtech,
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B’burg, April 04, 2007.
Sampada Karkare. Fullerenes. Ramnarain Ruia College, India, March15, 2004
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References will be provided on request.
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