Medical Research

CICELY WILLIAMS

**** ********* *****, ******, ***** Carolina 27703 Home:

910-***-**** - Cell: 910-***-**** : ******@*****.***

Professional Overview

Professional scientist with eight years of experience in molecular biology, animal microsurgery, and basic physiological

techniques. Areas of expertise include experimental study design, data collection, and analysis with focus in

Cardiovascular and Neuroscience research. Proven record of novel data findings resulting in publications, new or

extended grant funding, as well as discovery of new drug targets for treatment of various human disease.

Core Qualifications

Superb organizational skills Excellent communication skills

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Expertise in data analysis and identifying trends Strong attention to detail

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Experience

Research Analyst

January 2009 to Current

Biomedical/Biotechnology Research Institute – Durham, NC

Conducting studies using hypertensive animal models along with biochemical, physiological, and molecular

techniques to explore novel pharmacological targets for the treatment of cardiovascular disease:

● Collaborate with Principal Investigator(s) in preparation of manuscript publications, grant funding and in

developing new ideas and plans for future research studies.

● Evaluate and interpret collected research data in conjunction with principal investigator(s) when applicable;

prepare oral presentations and written reports summarizing analysis, updated progression, along with trends

and appropriate recommendations or conclusion.

● Prepare reagents and solutions as needed for daily experiments.

● Provide advanced troubleshooting and problem solving skills.

● Follow established protocols and guidelines in the collection of research data, as well as create and

establish protocols according to guidelines for new techniques.

● Provide daily supervision or oversight of laboratory operations, personnel, and, maintain sufficient

inventory of laboratory supplies to allow for performance of duties and maintenance of laboratory

equipment.

● Review journals, abstracts and scientific literature to ensure current knowledge regarding previous studies,

and to remain current of new developments to aid in future experimental design of new studies.

● Perform vital sign measurements, anesthetization, and microsurgeries in mouse and rat models according to

established protocols and in compliance with the Animal Welfare Act and Public Health Service(PHS)of Humane

Care and Use of Laboratory Animals policy

● Identify expression and translocation of specified proteins using cell culture, BCA assay and SDS page

techniques.

● Examine effects of calcium sensing agonists such as ( Calindol, NPS R568) and antagonists such as

( Calhex 231 and NPS 2143) to explore receptor signaling in mouse and rat tissue, as well as in human

embryonic kidney (HEK) 293 and neuroblastoma (B35) cells.

Graduate Research Assistant

January 2006 to January 2008

Biomedical/Biotechnology Research Institute – Durham, NC

Designed and carried out studies to investigate altered physiological processes in salt-induced hypertension using basic

physiological and molecular techniques:

● Designed cardiovascular research studies, collected and recorded data, and used statistical analysis to

conclude results.

● Prepared reports, abstracts, posters, and presentations for weekly lab meetings and annual scientific

meetings

● Collaborated with Principal Investigator and other team members on projects, manuscript publications, and

grants.

● Maintained sufficient inventory of materials and supplies, and ensured Good Laboratory Practice (GLP)

and laboratory safety procedures were followed.

● Performed small rodent microsurgeries and vessel relaxation studies in cardiovascular research.

● Employed immunochemistry, mass spectrometry, and polymerase chain reaction (PCR) techniques in

experiments carried out.

● Received American Association for Laboratory Animal Science (AALAS) certification training in animal care

for research and education through AALAS Learning Library.

Research Technician II

January 2003 to January 2006

Duke University Medical Center – Durham, NC

Managed transgenic mouse model colonies in Neuroscience Laboratory for studies conducted on normal and

abnormal development in structural body organs:

● Managed transgenic mouse colonies; duties included: setting up matings, intraperitoneal drug injections,

genotyping, and dissections with all procedures carried out according to established protocol and Animal

Welfare Act and PHS policy

● Collected, complied, and documented all daily activities and results accurately

● Ordered lab supplies, materials, and animal models to maintain sufficient inventory to ensure productivity

● Trained new personnel and medical students

● Collaborated with team members to achieve timely time lines and goals

● Acknowledged in manuscript for mouse husbandry work

● Murim Choi,Rolf W. Stottmann, Yu-Ping Yang,Erik N. Meyers, John Klingensmith. “The bone

morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis." Circulation

Research.2007;100:220-228.

Education

North Carolina Central University 2009

Durham, NC, USA

Biology w/ minor Biomedical Sciences

Master of Science

University of North Carolina at Chapel Hill 2008

Chapel Hill, NC, USA

Medical Education Program (MED)

Certificate

Program Highlights:

● Exposure through seminars to translational research, clinical studies, health disparities, and medical

education

● Interaction with medical faculty

● Academic courses taken include: gross anatomy, biochemistry, microbiology, and histology

University of North Carolina June 2003

Wilmington, NC, USA

Biology

B.S

Publications – Journal Articles

• Williams C L, Awumey E, and Pointer MA. Impaired vessel relaxation response to extracellular calcium in

Dahl salt-sensitive rat. Hypertension-, 2008 Oct. online. Abstract.

• Eley SL, Allen CM, Williams CL, Bukoski RD, and Pointer MA. Action of thiazide on renal interstitial calcium. Am

J Hypertens. 2008 Jul; 21(7):814-9.

• Bridges LE, Williams CL, Pointer MA, Awumey EM. Mesenteric artery contraction and relaxation studies using

automated wire myography. J Vis Exp. 2011 Sep 22;(55).

Presentations

• 62nd High Blood Pressure Research Conference 2008 and Scientific Sessions of the Council for High

Blood Pressure Research (HBPR, Sept 17-20, 2008). Atlanta, Georgia. • Williams C L, Awumey E, and Pointer

MA. “Impaired vessel relaxation response to extracellular calcium in Dahl salt-sensitive rats”.

• New England Science Symposium 2008 Harvard Medical School (Apr 6, 2008) Boston, Massachusetts.

Williams C L, Awumey E, and Pointer MA. “Impaired vessel relaxation response to extracellular calcium in Dahl salt-

sensitive rats”.

Experimental Biology (EB2012) San Diego, CA 2012. Awumey EM, Bridges LE, Williams CL, Diz DI. "Nitric Oxide

Synthase knockout modulates Ca2+-sensing receptor expression and signaling in mesenteric arteries." FASEBJ.

xx:A3381,2012.

Fellowships and Awards

● Biomedical Biotechnical Research Institute (BBRI) Fellow 2006

● NASA grant award recipient 2007

Technical Skills

Strategic planning, project management, data analysis, team collaboration, SDS page, cell culture, DNA and RNA

extractions, immunochemistry, PCR, RT-PCR, small animal microsurgeries,animal vital sign measurements using

plethsmography and telemetry, siRNA gene silencing, protein chemistry, Sigma Stats and Plots software, Microsoft

Office software

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