High School Pharmaceutical

Katina Sylvestre DOSSOU (Ph.D)

Address in USA: **0 Conway Court, Exton, PA 19341;

E-mail: *********@*******.***

Social Security (available upon request)

Immigration Status in the US: Permanent Resident (Green Card Holder;

available upon request)

. EDUCATION

2007-2011: Ph.D. in Pharmaceutical and Biomedical Sciences, Title of

Thesis:

"LC enantioseparation of basic pharmaceuticals using chlorinated

polysaccharide based chiral stationary phase and non-aqueous

polar mobile phases" at the Laboratory of Analytical

Pharmaceutical Chemistry Ph.D. Degree earned in March 2011.

(Advisor: Professor J. Crommen).

2005-2007: MSc in Pharmaceutical sciences. Title of Thesis:

" HPLC enantioseparation of basic pharmaceuticals using a new

polysaccharide based chiral stationary phase and non-aqueous

polar mobile phases" The study was conducted at the Laboratory

of Analytical Pharmaceutical Chemistry, University of Liege-

Belgium (Advisor: Professor J. Crommen).

2003-2005: MSc in Biomedical Sciences in Toxicology (University of Liege-

Belgium)

Topic "Evaluation of the quality of ambient air and the risk for

the bordering population of the cement factories of Tournai and

Antoing (Belgium)" (Advisor: Professor Jean Degraeve, Laboratory

of Industrial Toxicology, University of Li ge-Belgium)

1998-1999: MSc in Natural Sciences and Biochemistry (National University

of Benin, Benin)

1997-1998 BS in Natural Sciences and Biochemistry (National University of

Benin, Benin)

1995-1997: Diploma in Chemistry - Biology - Geology (National University

of Benin)

1994-1995: Baccalaureat "D" Mathematics and Biology (National High School

Leaving

Diploma) (Best of the Class of 1995)

. LIST OF Publcation

1. K.S. S. Dossou, P. Chiap, B. Chankvetadze, A.-C. Servais, M. Fillet, J.

Crommen.

Enantioseparation of basic pharmaceuticals using cellulose tris(4-chloro-

3-

methylphenylcarbamate) as chiral stationary phase and polar organic

mobile

phases. Journal of Chromatography A 2009; 1216, 7450-7455. DOI: 10.1016/

j.chroma.2009.05.081.

2. K.S.S. Dossou, P. Chiap, B. Chankvetadze, A.-C. Servais, M. Fillet, J.

Crommen.

Optimization of the LC enantioseparation of chiral pharmaceuticals using

cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral selector and

polar

non-aqueous mobile phases. Journal of Separation Science 2010, 33; 1699-

1707.

DOI: 10.1002/ jssc.201000049

3. K.S.S. Dossou, P. Chiap, A.-C. Servais, M. Fillet, J. Crommen.

Development and validation of LC method for the enantiomeric purity

determination of S-ropivacaine in a pharmaceutical formulation using a

recently commercialized cellulose-based chiral stationary phase and polar

non-

aqueous mobile phase. Journal of Pharmaceutical and biomedical analysis

2011, 54,

687-693 DOI: 10.1016/ j.jpba.2010.10.020.

4. K.S. S. Dossou, P. Chiap, A.-C. Servais, M. Fillet, J. Crommen

Evaluation of chlorine containing cellulose-based chiral stationary

phases for the LC enantioseparation of basic pharmaceuticals using polar

non-aqueous mobile phases. Journal of Separation Science 2011, 34, 617-

622. DOI 10.1002/ jssc.201000774

5. K.S.S. Dossou, P.A. Edorh, P. Chiap, B. Chankvetadze, A.-C. Servais, M.

Fillet, J. Crommen.

Determination of enantiomeric purity of S-amlodipine by chiral LC

with emphasis on reversal of enantiomer elution ordeDetermination of

enantiomeric purity of S-amlodipine by chiral LC with emphasis on

reversal of enantiomeric elution order (Journal of Separation Sciences,

2011, in press).

. ATTENDANCE AT NATIONAL & INTERNATIONAL CONFERENCES:

posters and oral communications

"LC method for the enantiomeric purity determination of S-amlodipine with

special emphasis on reversal of enantiomer elution order using chlorinated

cellulose-based chiral stationary phases and polar non-aqueous mobile

phases"

K. S.S. Dossou, P. A. Edorh, P. Chiap, B. Chankvetadze, A.-C. Servais, M.

Fillet, J. Crommen.

Poster presentation at 36th International Symposium on High Performance

Liquid Phase

Separations and related techniques, "HPLC 2011" (Budapest, hungary), June

2011.

"Development and validation of LC method for determination of enantiomeric

purity of S-ropivacaine in a pharmaceutical formulation using a recently

commercialized cellulose based chiral stationary phase and non-aqueaous

mobile phases."

K.S.S. Dossou, P. Chiap, A.-C. Servais, M. Fillet, J. Crommen.

Poster presentation at Drug Analysis 2010 (Antwerp, Belgium), September 21-

24, 2010.

"Evaluation of recently developed cellulose-based chiral stationary phases

for the LC enantioseparation of basic pharmaceuticals using polar non-

aqueous mobile phases."

K.S.S. Dossou, P. Chiap, A.-C. Servais, M. Fillet, J. Crommen.

Poster presentation at 34th International Symposium on High Performance

Liquid Phase

Separations and related techniques, "HPLC 2009" (Dresden, Germany), June

2009.

"A screening study of chiral pharmaceutical using tris(4-chloro-3-

methylphenylcarbamate) of cellulose-based stationary phase and polar

organic phases."

K.S.S. Dossou, P. Chiap, A.-C. Servais, M. Fillet, J. Crommen.

Poster Presentation at 33rd International Symposium on High Performance

Liquid Phase Separations and related techniques, "HPLC 2008" (Kyoto,

Japan), December, 2008.

"Comparison of different cellulose based chiral stationary phases for the

LC enantioresolution of basic drugs using polar organic mobile phases."

K.S.S. Dossou, P. Chiap, A.-C. Servais, M. Fillet, J. Crommen.

Contribution to oral communication at 19th International symposium on

Pharmaceutical & Biomedical Analysis, "PBA 2008" (Gdansk, Poland), June

2008.

"Enantios paration de substances m dicamenteuses basiques par

chromatographie liquide l'aide d'une nouvelle phase stationnaire chirale

et de phases mobiles polaires non aqueuses."

K.S.S. Dossou, P. Chiap, A.-C. Servais, M. Fillet, J. Crommen.

Oral communication at Forum des Jeunes Chercheurs du CIRM (Liege,

Belgium), February 02 2008.

"HPLC enantioseparation of basic drugs using recently developed

polysacharide-based CSPs with polar organic mobile phases."

K.S.S. Dossou, P. Chiap, A.-C. Servais, M. Fillet, J. Crommen.

Contribution to oral communication at 12th International Meeting on Recent

Development in Pharmaceutical Analysis, "RDPA 2007" (Elbe Island, Italy),

September 2007.

"HPLC enantioseparation of basic pharmaceuticals using a new polysaccharide-

based chiral stationary and non-aqueous polar mobile phases."

K.S.S. Dossou, S. Ghiani, P. Chiap, A.-C. Servais, M. Fillet, J.Crommen.

Poster presentation at 31st International Symposium on High Performance

Liquid Phase Separations and Related Techniques, "HPLC 2007" (Gand,

Belgium), June 21-24, 2007.

. WORK EXPERIENCE

03-09/2011: Graduate Teaching Assistant working under Professor Marianne

Fillet.

Responsible for Introductory Course in High Performance Liquid

Chromatography (HPLC) at the Laboratory of Analytical Pharmaceutical

Chemistry of Professor Marianne Fillet (University of Li ge) for unemployed

workers aiming to re-oriente themselves in analytical chemistry in order to

re-enter the job market

03-06/2008; /2009; /2010: Responsible for Introductory Course in High

Performance

Liquid Chromatography (HPLC) at the Laboratory of Analytical

Pharmaceutical Chemistry of Professor J. Crommen (University of Li ge) for

unemployed workers

aiming to re-enter the job market for a career in analytical chemistry.

.

11/2009 & 04/2010: Responsible for Introductory and Training Course in High

Performance Liquid Chromatography (HPLC) at the Laboratory of Analytical

Pharmaceutical Chemistry of Professor J. Crommen (University of Li ge) in

pharmaceutical analysis for graduate students in Masters Degree Program in

Biomedical and Pharmaceutical sciences at University of Liege, Belgium

(Equivalent of Graduate Teaching Assistantship).

10/06-09/07: LC Method Development and Optimization of enantioseparation of

twelve basic pharmaceuticals using a new polysaccharides-based chiral

stationary and non-aqueous polar mobile phases at the Laboratory of

Analytical Pharmaceutical Chemistry under the mentorship of Prof. J.

Crommen.

07/05-10/05: Training Course in High Performance Liquid Chromatography

(HPLC) for

undergraduate and entry graduate students at the Laboratory of Analytical

Pharmaceutical Chemistry of Professor J. Crommen (University of Li ge-

Belgium) .

01/03-09/03: Research Assistant in Biochemistry of Proteins Laboratory of

Professor

Hyacinthe AHISSOU, Cotonou, Republic of Benin (West Africa).

10/99-06/03: High School Teacher; Biology & Mathematics, Public School,

Cotonou,

Republic of Benin (West Africa).

Technical Skills

- Method development and validation

- High Performance Liquid Chromatography (HPLC)

- Gas chromatography and capillary electrophoresis

- Chromatography of affinity on GSH-agarose column

- Chromatography of exclusion on Sephadex column

- Gel electrophoresis

- Extraction of DNA of Plasmodium faciparum

- Purification of acid phosphatase and study of its enzymatic parameters

- PCR: amplification of DihydroFolate R ductase (DHFR) gene

- Cloning and expression of Luciferase's cDNA in pBLUESCRIPT II / SK+

. Languages and computer skills

French: Fluent

English: Spoken and written

Informatic: Microsoft Word, Excel, PowerPoint, Origin 7.0, Modde 6.0,

JMP , Drylab, Chemwin, Internet.

. Extra-curricula activities

Basket Ball, soccer, movies and reading.

. Membership in Professional Society

Member of the "Soci t Belge des Sciences Pharmaceutiques" (The Belgium

Society of Pharmaceutical Sciences).

. Names and adress of referees

Professor Jacques Crommen, University of liege, Department of Analytical

Pharmaceutical Chemistry, Avenue de l'Hopital 1, Tower 4, level +3, 4000

Li ge-Belgium

Phone: 003*-*-***-**-** Fax: 003*-*-*******

Email: ********@***.**.**

Professor Marianne Fillet, University of liege, Department of Analytical

Pharmaceutical Chemistry, Avenue de l'Hopital 1, Tower 4, level +3, 4000

Li ge-Belgium

Phone: +32 4 366 4345 Fax: 003*-*-***-****

Email: ********.******@***.**.**

Dr Patrice Chiap, University Hospital of Li ge, Advanced Technology

Corporation (A.T.C.), Avenue de l'Hopital 1, 4000 Li ge-Belgium

Phone: 003*-*-***-**-**

Email: *.*****@***.**.**

Dr Cornelius E. Uboh, PA Equine Toxicology and Research Center, West

Chester University, 220 East Rosedale Avenue, West Chester, PA 19382, USA

Phone: 610-***-**** fax: 610-***-****

Email: ********@***.*****.***

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