Software Development

FRANCIS “DAVID” TINGLEY, III Contact

SCIENTIST

cell 860-***-****

email: *********@*****.***

LinkedIn URL:

http://www.linkedin.com/in/fdavidtingley

A science-related research or lab position with a Biotech, Pharma or R&D company

Career Objective:

Summary

Experienced in vivo and in vitro pharmacologist with neurochemistry and mechanistic emphasis. Consummate project team member

for drug discovery, experimental design, and assay development. Highly proficient in all types of small rodent dosing techniq ues and

pharmacology sampling. Seasoned HPLC operator (EC, fluoro) and chromatography software server for data capture and usage by

8 clients. Motivated, energetic, communicative and detail-oriented scientist that works well in a team environment. Co-discoverer of

TM

marketed Chantix drug, successful clinical biomarker groundwork on 3 drugs, and developed novel in vivo assays for psychosis

and CNS targets.

Education

Masters Degree– Biology

University of Illinois, Springfield, Illinois

Thesis: Evidence for clonidine presynaptically modulating amino acid release in the r ostral ventral medulla: role in hypertension.

Bachelors Degree– Zoology

Olivet Nazarene University, Bourbonnais, Illinois

Chemistry and English, double minor

Work Experience

Pfizer Global Research & Development, Groton, Connecticut Full Time

Senior Scientist (Neurochemistry, HPLC for amino acids and monoamines, some behavioral Jul 1990 to Jun 2011

testing, ELISAs, RIAs, biomarker and assay development)

Extensive rodent in vivo skills utilizing all types of injection routes (SC, IP, IV, PO, ICV) plus cardiac puncture and CSF.

HPLC-EC and fluorescence maintenance with responsibility for Agilent EZChrom Server software application and data

capture (8 users, 15 instruments, 8 PCs). Waters, Shimadzu, ANTEC, ESA.

Drug dissolution and formulation skills for animal dosing along with sample preparation using tissues and body fluids.

Assay development for biomarkers, behavior and HPLC methods. CSF drawing skills in rodents and the mentoring of

others.

Program Proficiencies: MS office, MS Excel, MS Powerpoint, SAS Statview, LabStats, GraphPad Prism, Softmax, IDBS

Biobook e-notebook GDMS regulatory doc preparation, PYXIS Controlled Substances, Granite software for Animal Use

protocols

Implemented and managed f departmental lab notebooks, guidelines, mentoring and use of archiving software

SIU School of Medicine, Springfield, Illinois Full Time

Research Assistant (Neurochemistry, Gilson HPLC, amino acid release studies) Aug 1988 to 1990

HPLC maintenance, protein purification, blood pressure studies, enzyme kinetics, gel electrophoresis, fraction collector

use, rodent handling, tissue preparation, and centrifugation techniques.

Accomplishments

Co-discoverer of marketed drug (smoking cessation, CHANTIXTM

Supervised the work of 6 summer students and mentored them in drug discovery process

Established groundwork results for 3 successful biomarker programs for clinical trials yielding proof of mechanism

Initiated, managed, and maintained chromatography server for HPLC data capture using Agilent EZChrom

software

Established and managed laboratory notebook system for archiving and QC’ing of colleague notebooks

Memberships/Awards

New York Academy of Sciences 2009 - present

1992 – present

Society for Neuroscience

Julius Axelrod Travel Award to present original research at Society for Neuroscience 2009, Chicago, IL

TM

Prix Galien Award 2007 for discovery of Chantix drug (original project team member)

3 Individual Performance Awards (Pfizer, Inc) 2006, 2007 and 2010 (translational biomarkers, profiling competitor’s

drug for licensing, and integration of new employees to chromatography client server)

Community service award for local Science Fair Design and Participation

Who's Who Among American Colleges and Universities

Some Recent Publications:

C A. Strick, C. Li, L. Scott, B. Harvey, M. H., S. J. Steyn, M. A. Piotrowski, L. C. James, J. T. Downs, B. Rago, S. L.

Becker, A. El-Kattan, Y. Xu, A. Ganong, F. D. Tingley,III, A. D. Ramirez, P. A Seymour, M. Boucher, V.

Guanowsky, D. Chapin, M. J. Majchrzak, C. B. Fox, C. J. Schmidt, A. J. Duplantier, Modulation of NMDA receptor

function by inhibition of d-amino acid oxidase in rodent brain. Neuropharm. 2011 (submitted).

Y. Zhang, F. D. Tingley, III, M.Tella, X. Yang, J. Liu, Wenlin Li, C. Schmidt, and R. Steenwyk. Development and

validation of a sample stabilization strategy and a UPLC-MS/MS method for the simultaneous quantitation of

acetylcholine, histamine, and its metabolites in rat cerebrospinal fluid. Jnl of Neurosci Meth. 2011 (accepted).

Zhang, L; Brodney, M.; Candler, J.; Doran, A.; Duplantier, A.; Efremov, I.; Evrard, E.; Kraus, K.; Ganong, A.; Haas

J; Hanks, Ashley; J., K.; Lazzaro, J.; Maklad, N.; McCarthy, S.; Qian, W.; Rogers, B.; Rottas, M.; Schmidt, C.;

Siuciak, J.; Tingley, F; Zhang, Q. 1-((1-Methyl-1H-imidazol-2-yl)methyl)-4-phenylpiperidines as mGluR2 Positive

Allosteric Modulators for the Treatment of Psychosis. J. Med. Chem. 2011 (online 03-03-2011).

H. Rollema, A. Shrikande, K.M. Ward, F.D. Tingley,III, J.W. Coe, B.T. O’Neill, E. Tseng, E.Q. Wang, R.J. Mather,

R.S. Hurst, K.E. Williams, M. de Vries, T. Cremers, S. Bertrand, and D. Bertrand. Pre-clinical properties of the

a4B2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy

for nicotine dependence. Brit. Jnl. Pharm. (2010), 1476-5381.

J.A. Lowe, S.L. DeNinno, S.E. Drozda, C.J. Schmidt, K.M. Ward, F.D. Tingley,III, M. Sanner, D. Tunucci, J.

Valentine. An octahydro-cyclopental[c]pyrrole series of inhibitors of the type 1 glycine transporter. Bioorganic &

Med. Chem. Letters, 20 (2010) 907-911.

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