Assistant C
Resume:
Cristina Grosanu
M.S. Medicinal Chemistry
Billerica MA 01821
e-mail ********@***.***
OBJECTIVE:
A position where I can leverage my skills and experience to advance drug
discovery efforts.
SUMMARY STATEMENT:
. Competent, resourceful, and industrious medicinal chemist with over 10
years of experience in small scale multi-step synthesis and compound
management.
. Extended experience toward the development of lead candidates within
several teams.
PROFESSIONAL EXPERIENCE
Pfizer, Cambridge Sample Logistics, Cambridge, MA
Research Scientist I 01/2010-
present
. Participated in the setup of the Sample Logistics lab, calibration,
validation, and programming of Tecan and Hamilton Star liquid
handlers, as well as nanoliter liquid handlers such as the humming
bird and mosquito.
. Assisted biologists in the creation of submittal sets appropriate to
their biological assays.
. Prepared near assay ready plates for a variety of projects, as well as
single point concentration plates for pharmaceutical profile assays.
. Organized the lab schedule efficiently which ensured a four hour turn-
around time from the ordering instance.
. Maintained the sample storage system (Tekcel) for in house and
outsourced compounds.
. Established a professional relationship with service engineers
representing companies such as Tecan, Hamilton, TTP labtech.
.
Wyeth Research, Discovery Medicinal Chemistry, Princeton, NJ
Research Scientist I 01/2008-
12/2009
Scientist II 02/2002-
01/2008
Scientist I 04/1999-12/2001
. Developed the SAR around lead molecules by synthesizing compounds of
interest and proposing target modifications to address program
criteria. Designed and synthesized compound libraries via parallel
synthesis to address the issues quickly and efficiently.
. Designed alternative synthetic routes and potential ways to improve
synthetic schemes/steps. Proficient in searching the literature and
pertinent databases for new starting points and synthetic strategies.
. Carried out the scale-up of potential drug candidates in a timely
manner.
. As a discovery team member, followed up on the biological data of all
the compounds, drew conclusions, and communicated these results to the
team.
. Compiled, prepared and presented posters summarizing the compounds
synthesized, as well as the biological data and the results drawn.
Collaborated on numerous publications based on the work conducted.
FMC Corp., Princeton, NJ 08/1998-
03/1999
Synthetic Chemist
. Synthesized various organic molecules under specific deadlines,
purified and characterized them by means of NMR, MS, HPLC, GC, and
TLC.
Long Island University, Brooklyn, NY
Teaching Assistant, Organic Chemistry Lab 09/1996-
05/1998
Research Assistant 09/1995-
04/1996
. Supervised organic chemistry lab.
. Synthesized and characterized various organic molecules such as
Grignard reagents, aspirin, and many others, using IR and NMR to
identify different functional groups.
EDUCATION
Master of Science in Chemistry, Physical Organic Chemistry, May 1998
Long Island University, University Plaza, Brooklyn, NY.
Bachelor of Science in Chemistry, Analytical Chemistry, September 1996
Long Island University, University Plaza, Brooklyn, NY.
PRESENTATIONS and PUBLICATIONS
1. Greenfield, A.; Grosanu, C., 'Convenient synthesis of primary
sulfonamides'. Tetrahedron Letters (2008), 49(44), 6300-6303.
2. Greenfield, A.; Grosanu, C.; Elokdah, H.; Robichaud, A. 'Dihydro [1, 4]
dioxino [2, 3-e] indazole derivatives as 5-hydroxytryptamine-6 ligands'.
U.S. Pat. Appl. Publ. (2007).
3. Elokdah, H.; Greenfield, A.; Grosanu, C.; Robichaud, A. Substituted-
dihydro [1, 4] oxazino [2, 3, 4-hi] indazole derivatives as 5-HT6 ligands.
U.S. Pat. Appl. Publ. (2007).
4. Greenfield, A.; Grosanu, C.; Elokdah, H.; Robichaud, A. 'Dihydro [1, 4]
oxazino [2, 3, 4-hi] indazole derivatives as 5-hydroxytryptamine-6
ligands'. U.S. Pat. Appl. Publ. (2007).
5. Elokdah, H.; Greenfield, A.; Liu, K.; Mcfarlane, G.; Grosanu, C.; Lo,
J.; Robichaud, A. 'Preparation of azinyl-3-sulfonylindazole derivatives as
5-hydroxytryptamine-6 ligands'. U.S. Pat. Appl. Publ. (2007).
6. Elokdah, H.; Greenfield, A.; Liu, K.; McDevitt, R.; McFarlane, G.;
Grosanu, C.; Lo, J.; Li, Y.; Robichaud, A.; Bernotas, R. 'Preparation of
substituted-3-sulfonylindazole derivatives as 5-HT6 receptor modulators for
treating CNS disorders'. U.S. Pat. Appl. Publ. (2007).
7. Greenfield, A.; Grosanu, C.; Dunlop, J.; McIlvain, B.; Carrick, T.; Jow,
B.; Lu, Q.; Kowal, D.; Williams, J.; Butera, J., 'Synthesis and biological
activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and
diaminopropionic acid analogs as potent inhibitors of the high-affinity
glutamate transporter EAAT-2'. Bioorganic & Medicinal Chemistry Letters
(2005), 15(22), 4985-4988.
8. Dunlop, J.; McIlvain, H. B.; Carrick, T.; Jow, B.; Lu, Q.; Kowal, D.;
Lin, S.; Greenfield, A.; Grosanu, C.; Fan, K.; Petroski, R.; Williams, J.;
Foster, A.; Butera, J. Characterization of novel aryl-ether, biaryl, and
fluorene aspartic acid and diaminopropionic acid analogs as potent
inhibitors of the high-affinity glutamate transporter EAAT2. Molecular
Pharmacology (2005), 68(4), 974-982.
9. Greenfield, A.; Grosanu, C.; Tawa, G..; Childers, W..; Harrison, B.;
Magolda, R.; Robichaud, A.; Aulabaugh, A.; Chan, H.; Cowling, R.; Fennel,
M.; Huang, Xinyi; H., Wah-Tung; Kapoor, B.; Ling, H.; Wood, A.. Design,
synthesis and biological activity of novel quinazolinone-based Caspase 3
inhibitors. Abstracts of Papers, 230th ACS National Meeting, Washington,
DC, United States, Aug. 28-Sept. 1, 2005 (2005).
10. Butera, J.; Greenfield, A.; Grosanu, C.; Dunlop, J.; McIlvain, B.;
Carrick, T.; Jow, B.; Lu, Q.; Kowal, D.; Williams, J.. Excitatory amino
acid transporters (EAATs): I. The search for selective EAAT modulators.
Abstracts of Papers, 230th ACS National Meeting, Washington, DC, United
States, Aug. 28-Sept. 1, 2005 (2005).
11. Greenfield, A.; Grosanu, C.; Dunlop, J.; McIlvain, B.; Carrick, T.;
Jow, B.; Lu, Q.; Kowal, D.; Fan, K.; Williams, J.; Butera, J. Excitatory
amino acid transporters (EAATs): II. Identification of potent and selective
EAAT-2 inhibitors. Abstracts of Papers, 230th ACS National Meeting,
Washington, DC, United States, Aug. 28-Sept. 1, 2005
12. Lujan-Upton, H..; Mangar, D.; Grosanu, C.. Conformational behavior of
sterically hindered Kemp's molecules as models for tactic polyacids: A
study using proton NMR and fluoroscence spectroscopy. Abstracts of Papers,
221st ACS National Meeting, San Diego, CA, United States, April 1-5, 2001
(2001).
13. Lujan-Upton, H.; Mangar, D.; Grosanu, C.. Sterically hindered Kemp's
triacid analogues. Abstracts of Papers, 221st ACS National Meeting, San
Diego, CA, United States, April 1-5, 2001.
14.Greenfield, A., Grosanu, C., Dunlop, J., Carrick, T., Butera, J.,
"Glutamate Transporter Modulators: From HTS hit to chemical lead", 9th
Chemical Sciences Symposium, Wyeth Research, Princeton, NJ, October 17,
2000.
15. Grosanu, Cristina. Conformational behavior of sterically hindered
analogs of Kemp's triacid. Book of Abstracts, 216th ACS National Meeting,
Boston, August 23-27 (1998),
16. Grosanu, Cristina, Lujan-Upton, H., Watson, S., "Sterically Hindered
Kemp's Analogs that Don't Flip", Discovery '98- First Annual Student Poster
Presentation, Long Island University, Brooklyn Campus, April 29, 1998.
17. Grosanu, Cristina, Lujan-Upton, H., "Determination of the Relative
Ionic Binding Affinities of Metal Ions to Kemp's Triacid through
Fluorescence Quenching", American Chemical Society, New York Chemistry
Students Association, 44th Annual Undergraduate Research Symposium, Wagner
College, Staten Island, May 4th, 1996.
18. Grosanu, Cristina, Lujan-Upton, H., Watson, S., "Inhibition of
Conformational Ring Flip in Sterically Hindered Analogs of Kemp's Triacid",
Manuscript Master's thesis.
19. Grosanu, Cristina, "Investigation of antidepressant effects of
compounds extracted from Tiliae Flores", Romanian Young Chemists' Society,
Galati, Romania, May 1988.
SCHOLARSHIPS / AWARDS
*Long Island University Teaching Fellowship, 09/96-05/98
*ACS Recognition Award, May 4th, 1996.
*Romanian High-School Young Scientists' award, 1st prize, May 1988.
PROFESSIONAL MEMBERSHIPS
*American Chemical Society, member since 1995.
*Chemistry Club, ACS, Long Island University, treasurer, member since 1995
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