Design Assistant
Resume:
XIANGYING GUAN, Ph.D.
Wynnewood, PA 19096
*************@*****.***
EDUCATION
**** ****** ** **********, *********
State University of New York (SUNY) at Buffalo, Buffalo, NY
1999 Master of Science, Chemistry
Tianjin Normal University, Tianjin, China
WORKING EXPERIENCE
2008-present (Postdoctoral Research Fellow, Thomas Jefferson University)
• Investigating the interaction between anti-alcoholism drug abuse and normal aging
processes
• Design and Delivery of antisense nucleotides for knock-out of ALDH model both in vitro and
in vivo rat model
• Functional and proteomic analysis of alcoholic cardiomyopathy
• Developing and application of sensitive Reverse Phase – High Performance Liquid
Chromatography (HPLC) for an end-point measurement of drug action the level of
alcoholic-related metabolites.
2007-2008 (Postdoctoral Research Fellow, Drexel University)
• Applying various bioinformatics tools to design exon-skipping antisense oligonucleotides for
treatment of Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA)
• Developing and applying novel Nanopolymers for enhanced delivery of exon-splicing
oligonucleotides for treatment of DMD and SMA using germ-line knockout genetic mouse
models.
2002 to 2007 (Research Assistant, SUNY at Buffalo)
• Study function and kinetics of various matrix protein/mineral interactions under biological as
well as pathological conditions such that occur in tooth enamel formation, aggregation of
kidney stones, and opacity occurrence in intraocular lens.
EXPERIMENTAL SKILLS
Chemistry
Liquid chromatography–mass spectrometry (LC-MS or HPLC-MS)
Surface analysis: SEM, HR-TEM, XRD, DLS, SSA, XPS, and Zeta Potential
Chemical Analysis: NMR, MS, DSC/TGA/DTA, FT-IR, UV, AAS
Kinetics study: AFM, CC, DCC, SAX.
Bioassay
Immunohistochemistry
Gel Electrophoresis
Quantitive western blotting
Spectroscopic techniques including UV-Visible, Fluorescence and Circular Dichroism
Cell culture and maintenance
Rat hepatoma cell lines
Human hepatoma cell lines
Animal handling
Colony maintenance, IM and IP injections, various organs collection.
Genotyping PCR
Bioinformatics
Antisense oligoneucleotide design using DS Gene, and RNA Structure
Others
Lens implantation techniques were trained by Bausch & Lomb Inc, 2003.
PROFESSIONAL SOCIETIES AND ORGANIZATIONS
2007- American Chemical Society (ACS)
2009- Royal Society of Chemistry (MRSC)
2007- Optical Society of America (OSA)
2010- Research Society on Alcoholism (RSA)
OTHER PROFESSIONAL SERVICE
Journal reviewer
Crystal Growth & Design
International Journal of Immunopathology and Pharmacology
Journal of Biological Inorganic Chemistry
Journal of Biological Regulators & Homeostatic Agents
Journal of Biomedical Materials Research: Part A
Journal of Crystal Growth
Langmuir
Pediatric Nephrology
Polymers for Advanced Technologies
Consultantship
AST Products, Inc., MA (Pending)
PUBLICATIONS
Book
Guan, Xiangying. Kinetics Studies of Reactions at Solid-Liquid Interface: Simulation of
Calcification. Germany: VDM Verlag Dr. Müller Publisher, 2009.
Peer-Reviewed Articles
1. Guan, Xiangying, Rubin E, Anni H. An Optimized Method for the Measurement of Acetaldehyde
by High-Performance Liquid Chromatography (2011) Alcoholism: Clinical & Experimental
Research, IN PRESS.
2. Guan, Xiangying, Schray, Rebecca C; Lykens, Nicole M; Williams, Jason H; and Lutz, Gordon
Oligonucleotide-mediated dystrophin expression in skeletal muscle of growth stimulated dystrophic
mice at various ages (2011) SUBMIT.
3. Williams, Jason H; Schray, Rebecca C; Guan, Xiangying; Patterson, Carlyn A; Tallent, Mclanie
K; Lutz, Gordon J. Antisense mediated induction of SMN expression in brain and spinal cord tissue
improves bodyweight and righting response in the SMN mouse. Journal of Clinical Pharmacology
(2008) 48, 1117-1119.
4. Sirsi, Shashank R; Schray, Rebecca C; Guan, Xiangying; Williams, Jason H; Michelle L.
Erney; and Lutz, Gordon J. Functionalized PEG-PEI copolymers complexed to exon skipping
oligonucleotides improve dystrophin expression in mdx mice Human Gene Therapy (2008) 19, 795-
806.
5. Guan, Xiangying; Wang, Lijun; Dosen, Anja; Tang, Ruikang; Giese, Rossman F.; Gioconidi,
Jennifer L.; Orme, Christine A.; Nancollas, George H., An understanding of renal stone
development in an oxalate-phosphate system. Langmuir (2008) 24, 7058-7060.
6. Guan, Xiangying; Wang, Lijun; Tang, Ruikang; Hoyer, John R.; Wierzbicki, Andrzej ; De
Yoreo, James J.; Nancollas, George H. Phosphorylation of Osteopontin Is Required forInhibition of
Calcium Oxalate Crystallization Journal of Physical Chemistry B (2008) 112, 9151-9157.
7. Guan, Xiangying; Tang, Ruikang; Nancollas, George H. The potential calcification of
octacalcium phosphate on intraocular lens surfaces. Journal of Biomedical Materials Research,
Part A (2004), 71A (3), 488-496.
8. Wang, Lijun; Guan, Xiangying; Yin, Haoyong; Moradian-Oldak, Janet; Nancollas, George H.,
Mimicking the Self-organized Microstructure of Tooth Enamel, Journal of Physical Chemistry C
(2008) 112, 5892-5899.
9. Wang, Lijun; Guan, Xiangying; Moradian-Oldak, Janet; Nancollas, George H. Amelogenin
Promotes the Formation of Elongated Apatite Microstructures in a Controlled Crystallization
System Journal of Physical Chemistry, C (2007), 111, 6398-6404.
10. Wu, Wenju; Guan, Xiangying; Tang, Ruikang; Hook, Daniel; Yan, Wenyan; Grobe, George;
Nancollas, George H. Calcification of Intraocular Implant Lens Surfaces. Langmuir (2004),
20(4), 1356-1361.
11. Pan, Yunxiang; Guan, Xiangying; Feng, Zengyuan; Wu, Yanson; Li, Xinyu. Dehydration
reaction of manganese(II) oxalate dihydrate in the solid state. New method in the study of non-
isothermal kinetics. Journal of Thermal Analysis and Calorimetry (1999), 55(3), 877-884.
12. Wang, Lijun; De Yoreo, James J.; Guan, Xiangying; Qiu, S. Roger; Hoyer, John R.; Nancollas,
George H. Constant Composition Studies Verify the Utility of the Cabrera-Vermilyea (C-V) Model
in Explaining Mechanisms of Calcium Oxalate Monohydrate Crystallization. Crystal Growth &
Design (2006), 6(8), 1769-1775.
13. Wang, Lijun; Qiu, S. Roger; Zachowicz, William; Guan, Xiangying; DeYoreo, James J.;
Nancollas, George H.; Hoyer, John R. Modulation of Calcium Oxalate Crystallization by Linear
Aspartic Acid-Rich Peptides. Langmuir (2006), 22, 7279-7285.
14. Wang, Lijun; Zhang, Wei; Qiu, S. Roger; Zachowicz, William J.; Guan, Xiangying; Tang,
Ruikang; Hoyer, John R.; De Yoreo, James J.; Nancollas, George H. Inhibition of calcium oxalate
monohydrate crystallization by the combination of citrate and osteopontin. Journal of Crystal
Growth (2006), 291(1), 160-165.
15. Tang, Ruikang; Darragh, Molly; Orme, Christine A.; Guan, Xiangying; Hoyer, John R.;
Nancollas, George H. Control of biomineralization dynamics by interfacial energies. Angewandte
Chemie, International Edition (2005), 44(24), 3698-3702.
16. Guan, Xiangying; Zhao, erru; Pan, Yunxiang. Computer Assistant Interface (CAI) Web-Page
in Physical Chemistry. Journal of Tianjin Normal University (natural science edition) (2001), 32(1),
46-50.
PRESENTATIONS
1. Guan, Xiangying; Helen Anni; Emanuel Rubin. (2009) Methods to screen for anti-alcoholism
drugs targeting aldehyde dehydrogenase. 32nd Annual Research Society on Alcoholism (RSA)
Scientific Conference. San Diego, CA, USA (Poster presentation).
2. Williams, Jason H; Schray, Rebecca C; Guan, Xiangying; Patterson, Carlyn A; Tallent, Melanie
K; Lutz. Gordon J. (2008) Antisense mediated induction of SMN expression in brain and spinal
cord tissue improves bodyweigh and righting response in the SMA mouse. 37th American College of
Clinical Pharmacology (ACCP) Annual Meeting, Philadelphia, PA, USA (Poster presentation).
3. Giocondi, Jennifer; Guan, Xiangying; King, Jonathan; Orme, Christine A; Nancollas, George H.
(2007) An In-Situ AFM Study of the Affect of Magnesium impurities on Brushite Growth. Materials
Research Society (MRS) 2007 Spring Meeting – Symposium T: The Nature of Design – Utilizing
Biology’s Protfolio, San Francisco, CA, USA. (Poster presentation).
4. Guan, Xiangying; Wang, Lijun; Dosen, Anja; Giocondi, Jennifer; Orme, Christine A.; Giese,
Ross,;Nancollas, Georege H. (2006) An understanding of renal stone development in an oxalate-
phosphate system The 75th Gordon Research Conference on Biomineralization, New London, NH,
USA. (Poster presentation).
5. Giocondi, Jennifer; Orme, Christine A; Guan, Xiangying; Nancollas, George H; Hoyer, John.
(2006) The effect of inorganic and organic modifiers on brushite crystal growth. Materials
Research Society (MRS) 2006 Fall Meeting – Symposium QQ: Solid-State Chemistry of Inorganic
Materials VI, Boston, MA, USA. (Poster presentation).
6 Guan, Xiangying; Nancollas, George H. (2005). The potential calcification of OCP on
Intraocular lens surfaces The 23rd Annual Graduate Student Symposium, Buffalo, NY, USA. (Oral
presentation).
7. Guan, Xiangying; Pan, Yunxiang; Sun, Jianhua. A kinetic and mechanistic study of the
Nonisothermal dehydration of the fourth period transition metal oxalates Proceedings of 10th
National Conference on Chemical Thermodynamics and Thermal Analysis, Plenum Press (2000) pp
267-268.
8. Pan, Yunxiang; Guan, Xiangying; Feng, Zengyuan; Li, Xiuyu; Wu, Yansun. (1998). A new
method determining mechanism function of solid state reaction – the non-isothermal kinetic of
dehydration of Nickel (II) oxalate dehydrate The 9th National Conference on Chemical
Thermodynamics and Thermal Analysis & Beijing International Hua Xia Conference on Thermal
Analysis and Calorimetry, Beijin, China. (Oral presentation by Xiangying Gaun).
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