Assistant Construction

Patrick T. Sheehan

*** ******** ** *** 2-401-***-****

Charlestown, MA 02129 *******.*.*******@*****.***

Professional Experience

The Broad Institute, June 2010 – August 2013 Chemical Biology Platform

Research Chemist

The Broad Institute, December 2007 – July 2010 Genome Sequencing Platform

Research Associate II

Apogee Technology, Inc., January 2007 – November 2007

Research Scientist

Genzyme, February 2006 – January 2007 Drug Discovery & Design

Analytical R&D Associate

Millennium Pharmaceuticals, Inc., October 2004 – December 2005

Research Assistant, Intern

Education

Suffolk University, Boston, MA

Bachelor of Science in Chemistry

(American Chemical Society Certified) January 2006

GPA 3.06/4.00

Honors: Dean’s List 2003, 2005

Research Experience

The Broad Institute, Research Chemist

● Executed multi-step syntheses to provide leads for fragment based drug discovery against

biological targets

● Performed purification, analysis, and compound characterizati on of synthesized fragment

libraries

● Screened fragment based libraries against biological targets using established methods and

techniques

The Broad Institute, Research Associate II

● Responsible for development, implementation, and method transfer of a size -selective

analytical method for DNA library construction using ion-exchange chromatography

● Investigated and executed new DNA library construction techniques including method

development and method transfer

● Performed routine DNA library construction and analysis using pre -established techniques

and protocols

Apogee Technology, Inc., Research Scientist

● Developed and executed analysis methods for polymer and MEMs based drug delivery

systems

● Created and analyzed formulations for solid state transdermal drug delivery as well design

and develop an accompanying coating device for the delivery system

● Performed routine enzymatic assays and HPLC analysis of in -process formulations and

formulation candidates

Genzyme, Analytical R&D Associate

● Accountable for analytical chemistry method execution and project assistance for new drug

trials

● Completed work within appropriate regulatory requirements, including FDA, EPA, Good

Laboratory Practices (GLP), and FDA current Good Manufacturing Practices (cGMPs)

● Provide investigations, and problem solving solutions for new drug candidates

Millennium Pharmaceuticals, Inc., Research Assistant, Intern

● Independently performed multistep organic synthesis using modern synthetic, purification,

and characterization techniques for an oncology drug

Investigated, designed and executed organic synthetic methods for 2H stable-isotope

●

compounds for a commercial product

● Characterized compounds by spectrometric techniques such as LC-MS, HPLC, and FT-

NMR to monitor the progress of the compound throughout the synthesis

Publications

“Selective Access to Trisubstituted Macrocyclic E- and Z-Alkenes from the Ring-Closing Metathesis

of Vinylsiloxanes” Y. Wang, M. Jimenez, P. Sheehan, C. Zhong, A. W. Hung, D.W. Young. Org.

Lett., 2013, 15 (6), pp 1218-122.

"Diversity-Oriented Synthesis Approach to Fragment-Based Screening" Wang, Y., Wach, JY,

Sheehan, P., Zhong, C., Zhan, C,. Harris, R., Almo, S, Bishop, J, Haggarty, S., Ramek, A., Berry, K.,

O'Herin, C., Koehler, A., Hung, A., Young, D.W., ACS Chem. Bio., Submitted July 2013.

“A Strategy Toward Enantioenriched Functionalized sp 2-sp3 Hybrid Heterocycles.” Wacht,, Jean-

Yves; Sheehan, Patrick; Schreiber, Stuart L.; Young, Damian. Org. Lett., Submitted August 2013.

“Synthesis of Four Isotopically Labeled Forms of a Proteasome Inhibitor, Bortezomib” Y. Li, M.

Plesescu, P. Sheehan, J. S. Daniels, S. Prakash. J. Labelled Comp. Radiopharm., 2007, 50 (5-6), pp

402-406.

Contact this candidate