Assistant Research

Isabelle SEARCY (ILTIS)

**** **** *** * *****: 612-***-****

Minneapolis, MN 55406 ********.****@*****.***

PROFESSIONAL EXPERIENCE

Center for Magnetic Resonance Research, University of Minnesota

ASSISTANT PROFESSOR 2013 - Present

RESEARCH ASSISTANT PROFESSOR 2008 - 2013

POSTDOCTORAL FELLOW 2005-2008

RESEARCH TOPICS:

- Identification of potential Magnetic Resonance Imaging (MRI) and spectroscopy (MRS) biomarkers in human

pathologies (cerebellar ataxias, Huntington disease);

- Assessment of an innovative cancer treatment approach using nanoparticles delivery to tumors in mice

using MRI;

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Exploration of brain metabolism in experimental rodent models (schizophrenia, effect of anesthesia) using

proton (1H) MRS;

MRS in the rat brain using carbon 13 (13C) hyperpolarized substances.

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EDUCATION

PH. D. in Biology, Centre de Résonance Magnétique Biologique et Médicale, 2005

Université de la Méditerranée (Aix-Marseille II)

DIPLOME D’ETUDES APPROFONDIES (MASTER’S THESIS) in Genetics 2001

Laboratoire de Génétique et Physiologie du Développement,

Université de la Méditerranée (Aix-Marseille II)

MAITRISE (Master of Science) and LICENCE in Cellular Biology 1999 - 2000

DIPLOME D’ETUDES UNIVERSITAIRES GENERALES in Life and Health Sciences 1998

Université de Provence (Aix-Marseille I)

VOLUNTEERING

Safety Committee at the Center for Magnetic Resonance Research 2012-Present

Consultative role to determine safety guidelines and compliance to IRB requirements

Wildlife Rehabilitation Center, Animal Care Crew 2009-2010

Daily care of recovering injured wild animals

SKILLS AND EXPERTISE

Biology / Science

Neurodegenerative diseases

Preclinical cancer research

Magnetic Resonance Imaging and Spectroscopy

Anesthesia for small animals

Heart physiology

Writing

Research Articles, conference abstracts, oral presentations

Grants (3 awarded)

Institutional Review Board and Institutional Animal Care and Use Committee applications

Softwares

Proficient in Microsoft Office suite (Excel, Powerpoint, Word)

Proficient in Endnote X6

Proficient in Adobe Acrobat Pro, Evernote, OneNote

Languages

French (Maternal)

English (Fluent)

HONORS, AWARDS AND PROFESSIONAL MEMBERSHIPS

2001 – Present International Society for Magnetic Resonance in Medicine

2013 Friedreich’s Ataxia Clinical Research Conference: Invited Speaker (Silver Springs, MD,

United States), June 6-7th 2013

2011 Neurobiology of Disease in Children, Ataxia Symposium: Invited Young Investigator

Lecturer (Savannah, United States), October 25th 2011

2010 Invited Junior Lecturer - Third Ataxia Investigators’ Meeting (AIM) (Chicago, United

States), March 9th – 12th, 2010

Young Investigator’s Award “Rising Star in Ataxia Research 2010”, National Ataxia

Foundation

RESEARCH SUPPORT AWARDED

Friedreich’s Ataxia Research Alliance

(PI: I. Searcy (Iltis), C. Lenglet) 12/15/12 - 12/14/13 $119,938

This fund is to support research aiming at understanding the physiopathology of the spinal cord in patients

affected by Friedreich’s ataxia using non-invasive MRI techniques.

Bob Allison Ataxia Research Center (PI: I. Searcy (Iltis)) 07/01/12 - 06/30/14 $98,690

This fund is to support research aiming at finding biomarkers in the central nervous system of patients with

Friedreich’s Ataxia using MRS techniques.

National Ataxia Foundation (PI: I. Searcy (Iltis)) 01/01/11 - 12/31/11 $35,000

This fund is to support research in patients with ataxia with oculomotor apraxia type 2 (AOA2). Specifically, this

project is to investigate brain metabolism in patients with AOA2 using proton MRS.

PUBLICATIONS

SELECTED PEER-REVIEWED ARTICLES (5 out of 17)

1. Iltis I, Hutter D, Bushara KO, Clark HB, Gross M, Eberly LE, Gomez CM, Öz G. 1H MR spectroscopy in

Friedreich’s ataxia and ataxia with oculomotor apraxia type 2. Brain research 2010,

doi:10.1016/j.brainres.2010.08.030

2. Iltis I, Koski DM, Eberly LE, Nelson CD, Deelchand DK, Valette J, Uğurbil K, Lim KO, Henry PG.

Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized

1

H MRS study. NMR Biomed 2009:22(7):737-44.

3. Iltis I, Marjańska M, Du F, Koski DM, Zhu XH, Uğurbil K, Chen W, Henry PG. 1H MRS in the rat brain under

pentobarbital anesthesia: Accurate quantification of in vivo spectra in the presence of propylene glycol. Magn

Reson Med 2008;59(3):631-5.

4. Iltis I, Kober F, Dalmasso C, Cozzone PJ, Bernard M. Noninvasive characterization of myocardial blood flow

in diabetic, hypertensive, and diabetic-hypertensive rats using spin-labeling MRI. Microcirculation

2005;12(8):607-614.

5. Iltis I, Kober F, Dalmasso C, Lan C, Cozzone PJ, Bernard M. In vivo assessment of myocardial blood flow in

rat heart using magnetic resonance imaging: effect of anesthesia. J Magn Reson Imaging 2005;22(2):242-247.

BOOK CHAPTER

Chapter: Magnetic Resonance Imaging and Spectroscopy in Huntington Disease, in Magnetic Resonance Imaging

in Movement Disorders edited by Tuite and Dagher, 2012, in press.

ORAL COMMUNICATIONS

1. Iltis I, Hutter D, Bushara KO, Clark HB, Gomez CM and Öz G. 1H MR Spectroscopy in Autosomal Recessive

Ataxias: Initial Results in Friedreich’s Ataxia and AOA2. Third Ataxia Investigators’ Meeting (AIM) (Chicago,

United States), March 9th – 12th, 2010

2. Iltis I, Koski DM, Ugurbil K, Henry PG. Single-Voxel 1H MRS of the Rat Brain: Effect of Anesthesia. Proc Joint

Annual Meeting ESMRMB-ISMRM 2007 (Berlin, Germany), 711, p. 162.

3. Iltis I, Koski D, Eberly L, Deelchand DK, Valette J, Lim KO, Ugurbil K, Henry PG. Effects of PCP on the

Prefrontal Cortex Metabolism in Intact, Anesthetized Rats. Proc Joint Annual Meeting ESMRMB-ISMRM 2007

(Berlin, Germany), 716, p. 163.

4. Iltis I, Kober F, Dalmasso C, Cozzone PJ, Bernard M. Non-invasive determination of myocardial blood flow

using arterial spin-labeling MRI in rat models of hypertension and type 1 diabetes. ESMRMB 2004 (21st Annual

Scientific Meeting), Magn Reson Mater Phys 2004.

5. Iltis I, Kober F, Desrois M, Lan C, Portha B, Cozzone PJ, Bernard M. Characterization of cardiovascular

alterations in Goto-Kakizaki rats, a type 2 diabetes model, using MRI methods. Interdisciplinary program 2001-

2004 Small Animal Imaging, Scientific Meeting for contracts awarded in 2001-2002, Marseille 2003.

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