Scientist
Resume:
Yong-Chun Zeng
**** ***** ****, *** *****, NC ***10
******@*****.***
OBJECTIVE
To obtain a challenging and rewarding position that allows me to contribute
my advanced educational, research, and organizational skills to a reputable
organization committed to excellence and advancements in science
SUMMARY OF QUALIFICATIONS
Leadership Skills
. Capable problem solver and decision maker; skilled in coaching and
delegating
. Proficient at planning, organizing and implementing projects and
programs
. Can operate effectively as a leader or member of a team
. In depth knowledge of GLP for drug safety study
. Capable of writing protocol, SOPs and relative forms
Technical Skills
. Pharmacokinetics/Toxicokinetics (WinNonlin),
Bioequivalence/Bioavailability, statistic analysis
. Pathological evaluation report for preclinical toxicity
. whole cell patch clamp
. in vivo surgery techniques such as mount electrodes into
hippocampus and cerebral ischemia
. microsurgical recorded renal sympathetic nerve single fiber
activity in vivo for cardiovascular regulation
. Necropsy and trimming for non-human primates, large and small
animals
. staining, microtome sectioning, review slides, microphotography,
proficiency with troubleshooting staining inconsistencies
. Immunohistochemical staining on interneurons, neurofibres, and
biomarkers for tumor
. colony inventory of genotyping (PCR) and maintaining for knockout
mice
. Competent with computer applications and related laboratory
equipment
Research Skills
. Neuroscience
. Pharmacology
. Physiology
. Histotechnology
PROFESSIONAL EXPERIENCE
LabCorp, RTP, NC 2012
Lab Service Team Leader, Dept. of Histology
Medicilon Preclinical Research LLC, Shanghai, China 2010-2011
Associate Director, Department of Pathology
MPI Research, Mattawan, MI 2007-2008
Research Associate III, Histology Plastics Laboratory, Analytical Dept, Bio-
Statistics Group
North Carolina State University, College of Veterinary Medicine, Raleigh,
NC 2005-2007
Postdoctoral Research Associate, Department of Molecular Biomedical Science
University of Nebraska Medical Center, Omaha, NE 1998-2004
Postdoctoral Research Associate, Department of Physiology, Department of
Microbiology & Pathology
Univ. of Rome 'la Sapienza', Univ. of Rome 'Tor Vergata', Rome, Univ.
of Camerino,Italy 1991-1994
Visiting Researcher
National Institute of Health, Rome, Italy
1989-1990
Visiting Researcher,Laboratory of Pharmacology
School of Medicine, Shanghai Jiao Tong University, Shanghai, China
1984-1989
Assistant Lecturer, Department of Pharmacology
EDUCATION
School of Medicine, Shanghai Jiao Tong University, Shanghai, China
MD in Medicine & Surgery
School of Medicine, Shanghai Jiao Tong University, Shanghai, China
MSc in Pharmacology
School of Medicine & Surgery, University of Rome "Tor Vergata", Rome, Italy
PhD in Neuroscience
PROFESSIONAL ORGANIZATIONS
. HTL(ASCP)CM (Histotechnologist Board Certification #2579) 2008-
2011, American Society for Clinical Pathology (member #04226410)
. The American Physiological Society, 2000-2005 (regular member
#33142, Neural Control & Autonomic Regulation)
. American Association for the Advancement of Science, 1993, 2005-
2006
PRESENTATED ABSTRACTS /PUBLISHED PAPERS
ABSTRACTS:
1) Zeng Y.C. Reddy D.S.
Progesterone-derived neurosteroid 3alpha-hydroxy 5alpha-pregnan-20-one
inhibits spontaneous recurrent seizures in a rat model of temporal lobe
epilepsy
The FASEB Journal, 21: 885.15, 2007
2) Reddy D.S. Zeng Y.C., Shetty A.K.
Diminished spontaneous recurrent seizure activity following GABAergic
neurosteroid therapy in the pilocarpine model of chronic epilepsy
2006 Neuroscience Meeting, Atlanta, Oct 14-18, 2006
3) Zeng Y.C., Schultz H.D.
Effects of oxidative stress on TTX-r Nav 1.8 and Nav 1.9 INa in cardiac
afferent vagal neurons in diabetic rats.
The FASEB Journal, 18(5):A1258, 2004
4) Zeng Y.C., Li Y., Schultz H.D.
Oxidative stress and cardiac afferents in diabetes
The FASEB Journal, 17(5):A886, 2003
5) Zeng Y.C., Sun S.Y., Rozanski G., Xia X.H., Reddy P., Schultz H.D.
Superoxide anion attenuated INa in cardiac vagal chemosensory neurons from
diabetic rats
The FASEB Journal,16(5):829, 2002
6) Zeng Y.C., Sun S.Y., Xia X.H., Reddy P., Li Y., Schultz H.D.
Effect of exercise and heart failure on NOS isoforms in the carotid body of
rabbits
The FASEB Journal, 16(5):829, 2002
7) Xia X.H., Sun S.Y., Cornish K.G., Reddy P., Zeng Y.C., Schultz H.D.
Role of dopamine in the enhancement of peripheral chemoreflex function in
heart failure
The FASEB Journal, 16(5):828, 2002
8) Amenta F., Bongrani S., Bronzetti E., Cadel S., Ricci A., Valsecchi B.,
Zeng Y.C.
Effect of long term monoamine oxidase-B inhibitor treatment on the
structure of the hippocampus of the aged rat (Proceedings of Alzheimer's
Disease and Related Disorders held in Padova, Italy on 12-17 July 1993)
Advances in the Biosciences 87: 435-440, 1993
9) Zeng Y.C., Jin Z.J., Gu P.K.
Apply flash electroretinography in visual pharmacology and toxicology
Eur. J. Pharmacol. 183(6): 2436, 1990
ORIGINAL PAPERS:
1)Reddy D.S., Zeng Y.C.
Differential anesthetic activity of ketamine and the GABAergic neurosteroid
allopregnanolone in mice lacking progesterone receptor A and B subtypes
Methods and Findings in Experimental and Clinical Pharmacology 29(10):659-
64, 2007 Dec
2) Xiong H., Zeng Y.C., Zheng J., Thylin M.R., Gendelman H.E.,
Soluble HIV-1 infected macrophage secretory products mediate blockade of
long-term potentiation: a mechanism for cognitive dysfunction in HIV-1-
associated dementia
J.NeuroVirology 5: 519-528, 1999
3) Zheng J., Thylin M.R., Ghorpade A., Xiong H., Persidsky Y., Cotter R.,
Niemann D., Che MH., Zeng Y.C., Gelbard H.A., Shepard R.B., Swartz J.M.,
Gendelman H.E.,
Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic
mechanisms of HIV-1-associated dementia
J. Neuroimmunology 98: 185-200, 1999
4) Zeng Y.C., Bongrani S., Bronzetti E., Cadel S., Ricci A., Valsecchi B.,
Amenta F.,
Influence of long term treatment with L-deprenyl on the age-dependent
microanatomical changes in the rat hippocampus
Mech. Ageing Dev. 79:169-185, 1995
5) Zeng Y.C., Bongrani S., Bronzetti E., Cadel S., Ricci A., Valsecchi B.,
Amenta F.
Influence of long term treatment with L-deprenyl on the age-dependent
changes in rat brain microanatomy
Mechanisms of Ageing and Development 73:113-26, 1994
6) Zeng Y.C., Domenici M.R., Frank C., Sagratella S., Scotti de Carolis A.
Effects of adenosinergic drugs on hypoxia-induced electrophysiological
changes in rat hippocampal slices
Life Sci. 51(13): 1073-82, 1992
7) Zeng Y.C., Pezzola A., Scotti de Carolis A., Sagratella S.
Inhibitory influence of morphinans on ictal and interictal EEG changes
induced by cortical application of penicillin in rabbits: a comparative
study with NMDA antagonists and pentobarbitone
Pharmacol. Biochem. Behav. 43(2): 651-6, 1992
8) Zeng Y.C., Jin Z.J., Gu P.K.
Retinal toxicity in albino rabbits induced by intravitreal injection of
strophanthin-K
J. Ocul. Pharmacol. 6(1): 51-60, 1990
REVIEWS:
1) Xiong H., Zeng Y.C., Lewis T., Zheng J., Persidsky Y., Gendelman H.E.,
HIV-1 infected mononuclear phagocyte secretory products affect neuronal
physiology leading to cellular demise Relevance for HIV-1-associated
dementia
J.NeuroVirology 6 Suppl 1: S14-23, 2000
2) Polidori C., Zeng Y.C., Zaccheo D., Amenta F.
Age-related changes in the visual cortex: a review
Arch. Gerontol. Geriatr. 17: 145-164, 1993
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