Medical High School
Resume:
CURRICULUM VITAE:
Kelly J. Gauger
Pioneer Valley Life Sciences Institute
Baystate Health, Inc.
Springfield MA, 01199
Tel. 413-***-**** Fax 413-***-****
Email: *****.******@***.***
Academic Appointments
2007-Present Adjunct Research Assistant Professor, Department of Biology, University
of Massachusetts-Amherst
Education and Employment:
1996-2000. B.S., University of Miami, Miami, FL. 2000 (Biochemistry)
2000-2006 Ph. D., University of Massachusetts, Amherst, MA. 2006 (Molecular and
Cellular Biology)
2006-2011 Postdoc, Pioneer Valley Life Sciences Institute, Baystate Medical Center
(Breast Cancer)
2012-present Research Scientist, Pioneer Valley Life Sciences Institute, Baystate
Medical Center
Affiliations:
2000-2005 University of Massachusetts Molecular and Cellular Biology Program
2000-2005 University of Massachusetts Center for Neuroendocrine Studies
2006-Present Pioneer Valley Life Sciences Institute Breast Cancer Working Group
2008-Present American Association for Cancer Research, Member No. 137621
Awards, Distinctions, and Fellowships:
1996-2000 Deans List, University of Miami
1998-2000 University of Miami Peer Advisor
1999 Provost Honor Roll, University of Miami
1999 University of Miami Travel Stipend Award
1999 University of Massachusetts, Amherst NSF summer fellowship
2000 Graduation cum Laude, University of Miami
2000-2001 University of Massachusetts, Amherst Graduate Student Fellowship:
Teaching Assistant
2001 University of Massachusetts, Amherst Graduate Student Fellowship:
Research Assistant
2002 NIEHS Travel Stipend Award
2002-2004 University of Massachusetts, Amherst Center for Neuroendocrine
Studies NIMH training grant (T32MH47538)
2004 Gordon Research Conference on Environmental Endocrine Disruptors
Award recognizing Outstanding Work and Presentation
2006 American Association for Cancer Research Frontiers in Cancer Prevention
Research Scholar-in-Training Award
2007 Byron Prize: Annual award for the top dissertation in the Molecular and
Cellular Biology Program at the University of Massachusetts-Amherst
2011 Keystone Symposia Scholarship
Invited Talks:
Oct 2002 “Developmental Exposure to Polychlorinated Biphenyls (PCBs) Exerts a
Thyroid Hormone-Like Effect on Gene Expression in the Fetal Rat Brain.”
29th New England Endocrinology Conference, University of
Massachusetts, Amherst, MA
June 2004 “Polychlorinated Biphenyls (PCBs) Exert Thyroid Hormone-Like
Effects in the Fetal Rat Brain but do not bind to Thyroid Hormone
Receptors.” PCB Workshop, University of Illinois, College of Veterinary
Medicine, Champaign, IL
Sept 2004 “Thyroid hormone and brain development: Integrating information
from molecular approaches yields basic and applied insights to address
risk analysis of potential thyroid toxicants.” 32nd Annual Conference of
the European Teratology Society, Thessaloniki, Greece
Poster Presentations:
Sept 2001 Thyroid Hormone and Brain Development: Translating Molecular
Mechanisms to Population Risk, Research Triangle Park, NC
Society of Toxicology 41st Annual Meeting, Nashville, TN
March 2002
Center for Neuroendocrine Studies 6th Annual Symposium, University of
Oct 2003
Massachusetts, Amherst, MA
Society for Neuroscience 33rd Annual Meeting, New Orleans, MI
Nov 2003
June 2004 Gordon Research Conference, Environmental Endocrine Disruptors, New
London, NH
Center for Neuroendocrine Studies 7th Annual Symposium, University of
Oct 2004
Massachusetts, Amherst, MA
Society of Toxicology 44th Annual Meeting, New Orleans, MI
March 2005
American Association for Cancer Research 5th Annual Frontiers in Cancer
Nov 2006
Prevention Research Conference, Boston, MA
March 2008 Keystone Symposium: Signaling Pathways in Cancer and Development,
Steamboat Springs, CO.
October 2008 Research Day on Cancer: Tufts Medical Center, MA
January 2011 Keystone Symposium: Epithelial Plasticity and Epithelial to Mesenchymal
Transition meeting, Vancouver, BC
American Association for Cancer Research 102nd Annual Meeting;
April 2011
Innovation and Collaboration: The Path to Progress. Orlando, FL.
Research Support:
Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast
cancer, “sFRP: A Novel Secreted Factor as a Putative Enhancer For Treatment and
Prevention of Breast Cancer” (Kelly J. Gauger, PI, 2006-2007, $15,000)
Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast
cancer, “Inhibition of Wnt Signaling For the Treatment of Triple Negative Breast
Cancer” (Kelly J. Gauger, PI, 2007-2008, $12,000)
Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast
cancer, “Does loss of SFRP1 increase Breast Cancer Susceptibility” (Kelly J. Gauger, PI,
2008-2009, $10,000)
Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast
cancer, “Developing a treatment strategy for metastatic breast cancer” (Kelly J. Gauger,
PI, 2009-2010, $15,000)
Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast
cancer, “The role of SFRP1 loss on signaling pathways associated with the development
of breast cancer.” (Kelly J. Gauger, PI, 2010-2011, $13,000)
Collaborative Biomedical Research Program, “Protein expression patterns in primary and
metastatic breast carcinoma,” (Kelly J. Gauger, co-PI, Giovanna Crisi, co-PI, 2011-2012,
$25,000)
Published Abstracts:
Gauger KJ, Herzig CT, Zoeller RT (2002) Developmental exposure to polychlorinated
biphenyls exerts thyroid hormone-like effects on the expression of thyroid hormone-
responsive genes in the fetal rat brain. Annual Meeting of the Society of Toxicology,
Nashville, TN.
Gauger KJ, Kato Y, Haraguchi K, Lehmler HJ, Robertson LW, Zoeller RT (2003)
Paradoxical effects of PCBs on thyroid hormone action. Annual Meeting of the Society
for Neuroscience, New Orleans, LA.
Gauger KJ, Giera S, Zoeller RT (2005) The effects of PCBs on thyroid hormone
mediated action in vivo and in vitro. Annual Meeting of the Society of Toxicology, New
Orleans, LA.
Gauger KJ, Carvalho S, Smith-Schneider S (2006) The role of secreted frizzled-related
protein in parity-induced protection against breast cancer. Fifth Annual American
Association for Cancer Research International Conference: Frontiers in Cancer
Prevention Research, Boston, MA.
Gauger KJ, Hugh J, Ostrander J, Smith, Smith-Schneider S (2008) The Wnt/β-catenin
signaling antagonist, SFRP1, directly affects the tumorigenic properties of non-malignant
and malignant mammary epithelial cells. Keystone Symposium: Signaling Pathways in
Cancer and Development, Steamboat Springs, CO.
Gauger KJ, Kerry L. Chenausky KL, Murray ME, and Schneider SS (2011) Mammary
epithelial cells with reduced levels of SFRP1 exhibit an increased sensitivity to TGF-β
signaling by way of up-regulated ZEB2 expression. Keystone Symposium: Epithelial
Plasticity and Epithelial to Mesenchymal Transition, Vancouver, British Colombia,
Canada (to be published following Jan 21-Jan 26 meeting)
Gauger KJ, Kerry L. Chenausky KL, Murray ME, and Schneider SS (2011) Mammary
epithelial cells with reduced levels of SFRP1 exhibit an increased sensitivity to TGF-β
signaling. American Association for Cancer Research 102nd Annual Meeting; Innovation
and Collaboration: The Path to Progress. Orlando, FL.
Research Articles:
Iannacone EA, Yan AW, Gauger KJ, Dowling AL, Zoeller RT (2002) Thyroid hormone
exerts site specific effects on SRC-1 and N-CoR expression selectively in the neonatal rat
brain. Molecular and Cellular Endocrinology 15: 186: 49-59.
Zoeller RT, Dowling ALS, Herzig CTA, Iannacone EA, Gauger KJ, Bansal R (2002).
Thyroid hormone, brain development, and the environment. Environmental Health
Perspectives 110 (Suppl 3):355-361.
Gauger KJ, Kato Y, Haraguchi K, Lehmler HJ, Robertson LW, Bansal R, Zoeller RT
(2004). Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal
rat brain but do not bind to thyroid hormone receptors. Environmental Health
Perspectives 112 (Suppl) 5, 516-523.
You SH, Gauger KJ, Bansal R, Zoeller RT (2006). 4-Hydroxy-PCB106 acts a direct
thyroid hormone receptor agonist in rat GH3 cells. Molecular and Cellular
Endocrinology 257-258: 26-34.
Gauger KJ, Giera S, Sharlin DS, Bansal B, Iannacone E, Zoeller RT (2007).
Polychlorinated Biphenyls 105 And 118 Form Thyroid Hormone Receptor Agonists
Following Cytochrome P4501A1 Activation In Rat Pituitary GH3 Cells. Environmental
Health Perspectives 115 (Suppl 11), 1623-1611
Gauger KJ, Hugh JM, Troester MA, Schneider SS (2009). Down-regulation of SFRP1
in a mammary epithelial cell line promotes the development of a CD44high/CD24low
population which is invasive and resistant to anoikis. Cancer Cell International. May 7;
9:11
Gauger KJ, Rodríguez-Cortés A, Hartwich M, Schneider SS (2010). Rhodiola
Crenulata inhibits the tumorigenic properties of invasive mammary epithelial cells with
stem cell characteristics. Journal of Medicinal Plants Research. March 18;4:6, 446-454
Gauger KJ, Kerry L. Chenausky KL, Murray ME, Schneider SS (2011). Mammary
epithelial cells with reduced levels of SFRP1 exhibit an increased sensitivity to TGF-β
signaling by way of up-regulated ZEB2 expression. BMC Cancer. February 8;11 (1): 59
Gauger KJ, Shimono A, Crisi CM, Schneider SS. Loss of SFRP1 promotes ductal
branching in the murine mammary gland. BMC Developmental Biology. August 28;
12:25
Dunphy KA, Seo JH, Kim DJ, Roberts AL, Tao L, DiRenzo J, Balboni AL, Crisi GM,
Hagen MJ, Chandrasekaran T, Gauger KJ, Schneider SS, Jerry DJ. Oncogenic
transformation of mammary epithelial cells by Transforming Growth Factor beta
independent of mammary stem cell regulation. Cancer Cell International (In press)
Gauger KJ, Bassa LM, Henchey EM, Wyman J, Bentley B, Brown M, Shimono A,
Schneider SS. Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose
metabolism, and enhanced macrophage infiltration. Plos One (In press)
Gauger KJ and Schneider SS. The tumor suppressor secreted frizzled related protein 1
regulates p53-mediated apoptosis. Cell Biology International (In press)
Gauger KJ, Bassa LM, Henchey EM, Wyman J, Bentley B, Ser-Dolansky, Shimono A,
Schneider SS The effects of diet induced obesity on breast cancer associated pathways in
mice deficient in Sfrp1. Molecular Cancer (In review)
Invited Book Chapters:
Gauger KJ, Sharlin D, Zoeller RT (2006) Polychlorinated biphenyls as disruptors of
thyroid hormone action. In: PCBs: Recent Advances. L.W. Robertson and L.G. Hansen,
Eds. Univ Illinois Press, Champaign, IL
Gauger KJ and Schneider SS (2010) Rhodiola and Related Plants: A Role in Cancer
Prevention and Therapy. In: Bioactive Foods and Extracts: Cancer Treatment and
Prevention. R. R. Watson and V. R. Preedy, Eds. Taylor and Francis Group Boca Raton,
FL
Committee Services
Member of the Baystate Medical Center Institutional Animal Care and Use of Committee
(IACUC). 2006-Present.
Member of the Baystate Medical Center Institutional Biosafety Committee (IBC). 2006-
Present.
Students trained
Undergraduate Honors:
2006-2008 Jeremy Hugh, B.S. (2008) Admitted to New York Medical College.
Honors thesis submitted to the Honors College, University of Massachusetts. Thesis
Title: “SFRP1 Antagonizes the Wnt Pathway: Implications in Breast Cancer.”
2009-2010 Kerry Chenausky, B.S. (2010) Admitted to Massachusetts General
Hospital Institute of Health Professionals, M.S. program in adult/women’s health.
Honors thesis submitted to the Honors College, University of Massachusetts. Thesis
Title: “The Role ZEB Proteins Play in an Invasive Mammary Epithelial Cell Line”
Undergraduate Researchers:
2008-2009 Jennifer Ostrander, University of Massachusetts
2009-2011 Molly Murray, University of Massachusetts
High School Internships:
Summer 2010 Benjamin Gonzalaz (primary) along with 5 additional students with
Baystate Springfield Educational Partnership summer high school research program.
Student Committees
Jeremy Hugh, B.S.,University of Massachusetts
Kerry Chenausky, B.S., University of Massachusetts
Katherine Geromini, M.S., Molecular and Cellular Biology Program, University of
Massachusetts
Stefanie Giera, Ph.D., Molecular and Cellular Biology Program, University of
Massachusetts
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