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Medical High School

Location:
Springfield, MA
Posted:
August 07, 2013

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Resume:

CURRICULUM VITAE:

Kelly J. Gauger

Pioneer Valley Life Sciences Institute

Baystate Health, Inc.

**** **** **.

Springfield MA, 01199

Tel. 413-***-**** Fax 413-***-****

Email: ab9nxo@r.postjobfree.com

Academic Appointments

2007-Present Adjunct Research Assistant Professor, Department of Biology, University

of Massachusetts-Amherst

Education and Employment:

1996-2000. B.S., University of Miami, Miami, FL. 2000 (Biochemistry)

2000-2006 Ph. D., University of Massachusetts, Amherst, MA. 2006 (Molecular and

Cellular Biology)

2006-2011 Postdoc, Pioneer Valley Life Sciences Institute, Baystate Medical Center

(Breast Cancer)

2012-present Research Scientist, Pioneer Valley Life Sciences Institute, Baystate

Medical Center

Affiliations:

2000-2005 University of Massachusetts Molecular and Cellular Biology Program

2000-2005 University of Massachusetts Center for Neuroendocrine Studies

2006-Present Pioneer Valley Life Sciences Institute Breast Cancer Working Group

2008-Present American Association for Cancer Research, Member No. 137621

Awards, Distinctions, and Fellowships:

1996-2000 Deans List, University of Miami

1998-2000 University of Miami Peer Advisor

1999 Provost Honor Roll, University of Miami

1999 University of Miami Travel Stipend Award

1999 University of Massachusetts, Amherst NSF summer fellowship

2000 Graduation cum Laude, University of Miami

2000-2001 University of Massachusetts, Amherst Graduate Student Fellowship:

Teaching Assistant

2001 University of Massachusetts, Amherst Graduate Student Fellowship:

Research Assistant

2002 NIEHS Travel Stipend Award

2002-2004 University of Massachusetts, Amherst Center for Neuroendocrine

Studies NIMH training grant (T32MH47538)

2004 Gordon Research Conference on Environmental Endocrine Disruptors

Award recognizing Outstanding Work and Presentation

2006 American Association for Cancer Research Frontiers in Cancer Prevention

Research Scholar-in-Training Award

2007 Byron Prize: Annual award for the top dissertation in the Molecular and

Cellular Biology Program at the University of Massachusetts-Amherst

2011 Keystone Symposia Scholarship

Invited Talks:

Oct 2002 “Developmental Exposure to Polychlorinated Biphenyls (PCBs) Exerts a

Thyroid Hormone-Like Effect on Gene Expression in the Fetal Rat Brain.”

29th New England Endocrinology Conference, University of

Massachusetts, Amherst, MA

June 2004 “Polychlorinated Biphenyls (PCBs) Exert Thyroid Hormone-Like

Effects in the Fetal Rat Brain but do not bind to Thyroid Hormone

Receptors.” PCB Workshop, University of Illinois, College of Veterinary

Medicine, Champaign, IL

Sept 2004 “Thyroid hormone and brain development: Integrating information

from molecular approaches yields basic and applied insights to address

risk analysis of potential thyroid toxicants.” 32nd Annual Conference of

the European Teratology Society, Thessaloniki, Greece

Poster Presentations:

Sept 2001 Thyroid Hormone and Brain Development: Translating Molecular

Mechanisms to Population Risk, Research Triangle Park, NC

Society of Toxicology 41st Annual Meeting, Nashville, TN

March 2002

Center for Neuroendocrine Studies 6th Annual Symposium, University of

Oct 2003

Massachusetts, Amherst, MA

Society for Neuroscience 33rd Annual Meeting, New Orleans, MI

Nov 2003

June 2004 Gordon Research Conference, Environmental Endocrine Disruptors, New

London, NH

Center for Neuroendocrine Studies 7th Annual Symposium, University of

Oct 2004

Massachusetts, Amherst, MA

Society of Toxicology 44th Annual Meeting, New Orleans, MI

March 2005

American Association for Cancer Research 5th Annual Frontiers in Cancer

Nov 2006

Prevention Research Conference, Boston, MA

March 2008 Keystone Symposium: Signaling Pathways in Cancer and Development,

Steamboat Springs, CO.

October 2008 Research Day on Cancer: Tufts Medical Center, MA

January 2011 Keystone Symposium: Epithelial Plasticity and Epithelial to Mesenchymal

Transition meeting, Vancouver, BC

American Association for Cancer Research 102nd Annual Meeting;

April 2011

Innovation and Collaboration: The Path to Progress. Orlando, FL.

Research Support:

Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast

cancer, “sFRP: A Novel Secreted Factor as a Putative Enhancer For Treatment and

Prevention of Breast Cancer” (Kelly J. Gauger, PI, 2006-2007, $15,000)

Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast

cancer, “Inhibition of Wnt Signaling For the Treatment of Triple Negative Breast

Cancer” (Kelly J. Gauger, PI, 2007-2008, $12,000)

Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast

cancer, “Does loss of SFRP1 increase Breast Cancer Susceptibility” (Kelly J. Gauger, PI,

2008-2009, $10,000)

Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast

cancer, “Developing a treatment strategy for metastatic breast cancer” (Kelly J. Gauger,

PI, 2009-2010, $15,000)

Baystate Regional Cancer Program, Rays of Hope: A walk toward the cure for breast

cancer, “The role of SFRP1 loss on signaling pathways associated with the development

of breast cancer.” (Kelly J. Gauger, PI, 2010-2011, $13,000)

Collaborative Biomedical Research Program, “Protein expression patterns in primary and

metastatic breast carcinoma,” (Kelly J. Gauger, co-PI, Giovanna Crisi, co-PI, 2011-2012,

$25,000)

Published Abstracts:

Gauger KJ, Herzig CT, Zoeller RT (2002) Developmental exposure to polychlorinated

biphenyls exerts thyroid hormone-like effects on the expression of thyroid hormone-

responsive genes in the fetal rat brain. Annual Meeting of the Society of Toxicology,

Nashville, TN.

Gauger KJ, Kato Y, Haraguchi K, Lehmler HJ, Robertson LW, Zoeller RT (2003)

Paradoxical effects of PCBs on thyroid hormone action. Annual Meeting of the Society

for Neuroscience, New Orleans, LA.

Gauger KJ, Giera S, Zoeller RT (2005) The effects of PCBs on thyroid hormone

mediated action in vivo and in vitro. Annual Meeting of the Society of Toxicology, New

Orleans, LA.

Gauger KJ, Carvalho S, Smith-Schneider S (2006) The role of secreted frizzled-related

protein in parity-induced protection against breast cancer. Fifth Annual American

Association for Cancer Research International Conference: Frontiers in Cancer

Prevention Research, Boston, MA.

Gauger KJ, Hugh J, Ostrander J, Smith, Smith-Schneider S (2008) The Wnt/β-catenin

signaling antagonist, SFRP1, directly affects the tumorigenic properties of non-malignant

and malignant mammary epithelial cells. Keystone Symposium: Signaling Pathways in

Cancer and Development, Steamboat Springs, CO.

Gauger KJ, Kerry L. Chenausky KL, Murray ME, and Schneider SS (2011) Mammary

epithelial cells with reduced levels of SFRP1 exhibit an increased sensitivity to TGF-β

signaling by way of up-regulated ZEB2 expression. Keystone Symposium: Epithelial

Plasticity and Epithelial to Mesenchymal Transition, Vancouver, British Colombia,

Canada (to be published following Jan 21-Jan 26 meeting)

Gauger KJ, Kerry L. Chenausky KL, Murray ME, and Schneider SS (2011) Mammary

epithelial cells with reduced levels of SFRP1 exhibit an increased sensitivity to TGF-β

signaling. American Association for Cancer Research 102nd Annual Meeting; Innovation

and Collaboration: The Path to Progress. Orlando, FL.

Research Articles:

Iannacone EA, Yan AW, Gauger KJ, Dowling AL, Zoeller RT (2002) Thyroid hormone

exerts site specific effects on SRC-1 and N-CoR expression selectively in the neonatal rat

brain. Molecular and Cellular Endocrinology 15: 186: 49-59.

Zoeller RT, Dowling ALS, Herzig CTA, Iannacone EA, Gauger KJ, Bansal R (2002).

Thyroid hormone, brain development, and the environment. Environmental Health

Perspectives 110 (Suppl 3):355-361.

Gauger KJ, Kato Y, Haraguchi K, Lehmler HJ, Robertson LW, Bansal R, Zoeller RT

(2004). Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal

rat brain but do not bind to thyroid hormone receptors. Environmental Health

Perspectives 112 (Suppl) 5, 516-523.

You SH, Gauger KJ, Bansal R, Zoeller RT (2006). 4-Hydroxy-PCB106 acts a direct

thyroid hormone receptor agonist in rat GH3 cells. Molecular and Cellular

Endocrinology 257-258: 26-34.

Gauger KJ, Giera S, Sharlin DS, Bansal B, Iannacone E, Zoeller RT (2007).

Polychlorinated Biphenyls 105 And 118 Form Thyroid Hormone Receptor Agonists

Following Cytochrome P4501A1 Activation In Rat Pituitary GH3 Cells. Environmental

Health Perspectives 115 (Suppl 11), 1623-1611

Gauger KJ, Hugh JM, Troester MA, Schneider SS (2009). Down-regulation of SFRP1

in a mammary epithelial cell line promotes the development of a CD44high/CD24low

population which is invasive and resistant to anoikis. Cancer Cell International. May 7;

9:11

Gauger KJ, Rodríguez-Cortés A, Hartwich M, Schneider SS (2010). Rhodiola

Crenulata inhibits the tumorigenic properties of invasive mammary epithelial cells with

stem cell characteristics. Journal of Medicinal Plants Research. March 18;4:6, 446-454

Gauger KJ, Kerry L. Chenausky KL, Murray ME, Schneider SS (2011). Mammary

epithelial cells with reduced levels of SFRP1 exhibit an increased sensitivity to TGF-β

signaling by way of up-regulated ZEB2 expression. BMC Cancer. February 8;11 (1): 59

Gauger KJ, Shimono A, Crisi CM, Schneider SS. Loss of SFRP1 promotes ductal

branching in the murine mammary gland. BMC Developmental Biology. August 28;

12:25

Dunphy KA, Seo JH, Kim DJ, Roberts AL, Tao L, DiRenzo J, Balboni AL, Crisi GM,

Hagen MJ, Chandrasekaran T, Gauger KJ, Schneider SS, Jerry DJ. Oncogenic

transformation of mammary epithelial cells by Transforming Growth Factor beta

independent of mammary stem cell regulation. Cancer Cell International (In press)

Gauger KJ, Bassa LM, Henchey EM, Wyman J, Bentley B, Brown M, Shimono A,

Schneider SS. Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose

metabolism, and enhanced macrophage infiltration. Plos One (In press)

Gauger KJ and Schneider SS. The tumor suppressor secreted frizzled related protein 1

regulates p53-mediated apoptosis. Cell Biology International (In press)

Gauger KJ, Bassa LM, Henchey EM, Wyman J, Bentley B, Ser-Dolansky, Shimono A,

Schneider SS The effects of diet induced obesity on breast cancer associated pathways in

mice deficient in Sfrp1. Molecular Cancer (In review)

Invited Book Chapters:

Gauger KJ, Sharlin D, Zoeller RT (2006) Polychlorinated biphenyls as disruptors of

thyroid hormone action. In: PCBs: Recent Advances. L.W. Robertson and L.G. Hansen,

Eds. Univ Illinois Press, Champaign, IL

Gauger KJ and Schneider SS (2010) Rhodiola and Related Plants: A Role in Cancer

Prevention and Therapy. In: Bioactive Foods and Extracts: Cancer Treatment and

Prevention. R. R. Watson and V. R. Preedy, Eds. Taylor and Francis Group Boca Raton,

FL

Committee Services

Member of the Baystate Medical Center Institutional Animal Care and Use of Committee

(IACUC). 2006-Present.

Member of the Baystate Medical Center Institutional Biosafety Committee (IBC). 2006-

Present.

Students trained

Undergraduate Honors:

2006-2008 Jeremy Hugh, B.S. (2008) Admitted to New York Medical College.

Honors thesis submitted to the Honors College, University of Massachusetts. Thesis

Title: “SFRP1 Antagonizes the Wnt Pathway: Implications in Breast Cancer.”

2009-2010 Kerry Chenausky, B.S. (2010) Admitted to Massachusetts General

Hospital Institute of Health Professionals, M.S. program in adult/women’s health.

Honors thesis submitted to the Honors College, University of Massachusetts. Thesis

Title: “The Role ZEB Proteins Play in an Invasive Mammary Epithelial Cell Line”

Undergraduate Researchers:

2008-2009 Jennifer Ostrander, University of Massachusetts

2009-2011 Molly Murray, University of Massachusetts

High School Internships:

Summer 2010 Benjamin Gonzalaz (primary) along with 5 additional students with

Baystate Springfield Educational Partnership summer high school research program.

Student Committees

Jeremy Hugh, B.S.,University of Massachusetts

Kerry Chenausky, B.S., University of Massachusetts

Katherine Geromini, M.S., Molecular and Cellular Biology Program, University of

Massachusetts

Stefanie Giera, Ph.D., Molecular and Cellular Biology Program, University of

Massachusetts



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