Manager Development

VINCENT DARMENCY, Ph.D.

* ******* *****, **** ***, Somerville, MA 02144

Phone Number: 617-***-****

*********@*****.***

French Citizen; authorized to work in the United States

ORGANIC CHEMIST

Medicinal Chemistry

• Lead chemist in multidisciplinary project teams

• Lead generation and Lead optimization stages

• Design of new molecules through SAR analysis, using computational tools

• Working knowledge of ADMET concepts, in vitro and in vivo PK/PD,

and fundamental principles of pharmacology

• Experience in Oncology, CNS, Inflammation and Metabolic Diseases areas

Laboratory

• Plan synthetic routes and small libraries of organic molecules

• Scale-up development for in vivo and toxicology studies

• Characterization of organic molecules (NMR, LCMS, HPLC, GCMS, FTIR)

• Proficient in literature database searching (SciFinder, Reaxys)

Communication

• Effective oral and written presentation skills

• Regular project meetings and department presentations

• Ability to work in a team and in an international environment

• Fluent in English, French; and proficient scientific reading of German

EDUCATION

STANFORD UNIVERSITY, California, USA 2006 – 2008

Post-Doctoral Fellow - Synthetic Organic Chemistry

• Novel synthetic route to Merrilactone A analogues

• New analogues of highly potent cancer therapeutic lead Laulimalide

Advisor: Prof. Paul A. Wender

UNIVERSITY OF BERN, Switzerland 2003 – 2006

PhD - Synthetic Organic Chemistry

• Organoboranes as radical source for new tin-free radical transformations

• Supervisor of three undergraduate students

• Teaching Assistant in general and organic chemistry

Advisor: Prof. Philippe Renaud

UNIVERSITY OF SCIENCES OF MONTPELLIER, France 1999 – 2002

M.Sc. Automated Synthesis, Purification and Analysis of Biomolecules

B.Sc. Biomolecular Organic Chemistry

INSTITUTE OF TECHNOLOGY, Montpellier, France 1996 – 1998

Two-year Technical Degree in Chemistry

PROFESSIONAL EXPERIENCE

ADDEX THERAPEUTICS S.A., Geneva, Switzerland 2008 – 2012

Senior Scientist and Laboratory Head, Chemistry Department (2009 – 2012)

• Lead generation and Lead optimization

• Scale-up of preclinical candidates

• Management of outsourced resources for scale-up support

• Manager of two associate scientists

Vincent Darmency, Ph.D. Page 2

Industrial Post-Doctoral Position, Core Chemistry (2008 – 2009)

• Hit Validation of new allosteric modulators series

• Synthesis and development of novel molecular probes

NOVARTIS PHARMACEUTICALS, Basel, Switzerland March – Sept. 2002

Internship in Chemical and Analytical Development

• New approach of the total synthesis of antitumor agent Epothilone B

Advisors: Dr. Alain Leydet and Dr. Olivier Loiseleur

AVENTIS CROPSCIENCE, Lyon, France March - Aug. 2001

Internship in Fungicide Research

• Synthesis of heterocyclic analogues of a new fungicide Lead

Advisors: Dr. Alain Leydet and Stéphanie Gary

TOTAL CHEMISTRY RESEARCH AND DEVELOPMENT, Narbonne, France April – June 1998

Training Program

• Optimization of a kilo-lab synthesis of copper phtalocyanine

TRAINING COURSES

Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries,

Principles and Practice. Scientific Update Training Course, Nice, France April 5 – 7, 2011

9th Swiss Course on Medicinal Chemistry, Leysin, Switzerland Oct. 10 - 15, 2010

PUBLICATIONS

Novel Oral Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.

Addex Therapeutics SA, C. Bolea, S. Celanire, V. Darmency, C. Mordant, V. Pericolle, Y. Regereau, J.-P.

Rocher, R. Souissi 2013; WO Patent Application, filed January 16, 2013. Patent Pending.

Modified B-alkylcatecholboranes as radical precursors. M. Luethy; V. Darmency; P. Renaud;

European Journal of Organic Chemistry 2011, 3, 547-552.

An Efficient Radical Procedure for the Halogenation and Chalcogenation of B-alkylcatecholboranes.

A.-P. Schaffner; F. Montermini; D. Pozzi; V. Darmency; E. M. Scalan; P. Renaud;

Advanced Synthesis & Catalysis 2008, 350, 7-8, 1163-1167.

Boron: A Key Element in Radical Reactions. P. Renaud, A. Beauseigneur, A. Brecht-Forster, B.

Becattini, V. Darmency, S. Kandhasamy, F. Montermini, C. Ollivier, P. Panchaud, D. Pozzi, E. M.

Scanlan, A.-P. Schaffner, and V. Weber; Pure Appl. Chem. 2007, 79, 2, 223-233.

Radical Allylation of B-alkylcatecholboranes [ethyl 2 1S,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-

yl]methyl} acrylate. V. Darmency; E. M. Scanlan; A.- P. Schaffner; P. Renaud; B. Sui; D. P. Curran;

Organic Syntheses 2006, 83, 24-30.

Tin-free Radical Reactions Mediated by Organoboron Compounds. V. Darmency; P. Renaud;

Topics in Current Chemistry 2006, 263, (Radicals in Synthesis I), 71-106.

Radical-mediated Alkenylation, Alkynylation, Methanimination, and Cyanation of B-alkylcatecholboranes.

A.-P. Schaffner; V. Darmency; P. Renaud; Angewandte Chemie, International Edition 2006, 45, 35,

5847-5849.

Alkylation of Ethyl Pyruvate via Reductive Coupling of Alkenes and Ethyl 2-(Benzenesulfonylamino)

acrylate. V. Darmency, P. Renaud, Chimia 2005, 59, 3, 109-110.

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