State University Design

Olga O. Alekseeva

**** ****** **** **., ***. ***, Midland, GA 31820

Tel.: 440-***-**** (home); 617-***-**** (cell)

E-mail: ab9cpd@r.postjobfree.com

SUMMARY

. Synthetic organic and medicinal chemist with pharmaceutical and CRO

industrial experience

. Bioassay guided SAR studies for hit-to-lead and lead optimization

research

. Design and execution of multi-step syntheses of complex organic molecules

. Expertise in experimental work with high-energy, heat-, air-, and light-

sensitive compounds

. Analytical methods for structural and mechanistic studies; instrument

maintenance

EXPERIENCE

HPPE, LLC, Columbus, GA; Principal Scientist / Director 2013-present

. Set up a new R&D laboratory for custom synthesis, medicinal chemistry,

and analytical characterization. Synthesized compounds for pharmaceutical

and chemical industry.

Ricerca Biosciences, Concord, OH; Scientist, Sr. Scientist, Assoc.

Principal Scientist 2004-2012

. Lead optimization and hit-to-lead SAR studies in Parkinson's ((-syn,

MAO), cystic fibrosis (CFTR modulators), cancer (Trp-p8), and anti-

infective (DNA ligase) therapeutic areas using structure and ligand-based

drug design, including Src and other kinase inhibitors. Several compounds

advanced to animal studies.

. Designed and synthesized various N-, O-, and S-heterocycles; guanidines,

thioureas, and related compounds; substituted cyclopropanes; aliphatic

oligopeptides and retinoids; molecular probes with diazirine, azide, and

biotin groups. Prepared compounds in a fast-paced, productivity driven

environment.

. Optimized processes for pharmaceutical intermediates and API. Developed a

novel synthesis for opioid metabolites and optimized it for production.

Developed reactive crystallizations to improve solid form properties of

API. Handled multiple projects.

. Maintained NMR (400 MHz Bruker), LC-MS (Agilent), and prep-HPLC (Gilson)

instruments. Managed projects and teams, communicated with clients and

collaborators, prepared proposals and reports, technical parts of PCT

applications, NIH grants and contracts.

EMD Serono, Rockland, MA (Aerotek Scientific) -- Senior Scientist 2004-

2004

. Developed drug candidates for reproductive biology and related areas (DP

and EP agonists). SAR studies and lead optimization in cancer

chemotherapeutic agents (PI3K and MEK inhibitors).

. Accomplished multi-step syntheses of chiral prostaglandins. Synthesized

substituted quinazolines and other heterocycles. Purified compounds by

automated flash-chromatography, prep-HPLC; analyzed by HPLC, LCMS, NMR.

Organix, Inc., Woburn, MA -- Postdoctoral Research Associate 2001-2003

. SAR study in GPCR ligand area: for elucidation of pharmacological

mechanisms of marijuana and development of drugs for central nervous

system, CNS

. Synthesized (8-tetrahydrocannabinol (THC) analogs with diacetylene side

chains and a new series of pyrazole cannabinoid antagonists

. Separated complex mixtures by prep-TLC, flash, and dry-column vacuum

chromatography; characterized compounds with 1D, 2D (COSY, HSQC, HMBC)

NMR, LC/MS, FTIR

The Ohio State University, Columbus, OH -- Postdoctoral Researcher 1997-

2001

. Synthesized strained polyfunctional cyclopropanes and spiropentanes,

developed syntheses towards dinitroacetylene via various alkynes, alkenes,

and triazoles

. Developed new polyamide dendritic macro-monomers for low-shrinkage

composites for dentistry. Designed new hyperbranched amido-ester

biocompatible polymers

. Employed various preparative techniques for compounds from gases to

polymers. Purified light-sensitive, unstable, high-energy, etc. compounds.

Calculated organic structures with AM1, PM3, DFT, HF methods

St. Petersburg State University, Russia -- Instructor; Research/Teaching

Associate 1991-1997

Ph.D. Thesis: "Reactions of Aromatic N-Oxides with (-Acceptors" (1996)

. Developed efficient syntheses of 2-diazo-1,3-diketones with bulky and

heteroaromatic substituents. Established conformational composition of the

diazodiketones for mechanistic study of their Wolff rearrangement and

other transformations

. Synthesized 1,3-cycloadducts, stable molecular complexes, radical-ion

salts, and other products of aromatic N-oxides with electron deficient

alkenes. Developed synthetic methods using molecular complexes. Applied

spectral methods for mechanistic and structural studies.

. Taught undergraduate (synthetic) organic chemistry for 10 semesters. Co-

advised 4 M.S. graduates.

TRAINING AND PROFESSIONAL ACTIVITIES

Process Research in the Pharmaceutical Industry (ACS Course, E. Grabowski,

U. Dolling) 2012

. Design and Development of Practical Syntheses

Residential School on Medicinal Chemistry, Drew University, Madison, NJ

2009

. Chemistry and biology in drug discovery

Drug-Like Properties in Drug Discovery (ACS Course, Ed Kerns, Li Di)

2008

. Key pharmaceutical properties and their practical applications for lead

optimization.

Bruker NMR Training (Avance II), Billerica, MA 2008

. Advanced operation of the spectrometer for structure elucidation and

analysis of reactions.

Secretary of Organizing Committee of the 1-st International Conference of

Young Scholars 1994

St. Petersburg, Russia

. Prepared invitations, programs, and book of abstracts; communicated with

150 participants; managed site prep for oral and poster sessions;

submitted financial reports.

EDUCATION

Ph.D., Organic Chemistry, St. Petersburg State University (Russia) 1996

B.S./M.S., Chemistry, Leningrad State University (Russia)

PUBLICATIONS AND PRESENTATIONS

Fourteen publications and four international conference papers

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