Medical Engineering

Xiaoling (Charlene) Yang, PhD

** **** ** *** *** Cell phone: 706-***-****

Branford, CT 06405 E-mail: *********@*****.***

No employment sponsorship needed now or in the future http://www.linkedin.com/in/xyang

PROFILE

• Established expert in electrochemistry and bio-sensors

• Extensive experience in micro-/nano- fabrication, product development and system integration

• Solid Background in Bio-engineering and Medical Imaging

• Proficient in large dataset analysis and visualization with Matlab

• Extensive experience in modeling electrochemical systems with COMSOL

• Self-starter proactive in planning daily task and generating new ideas for the success of project

• Creative troubleshooter able to quickly identify problems and implement practical solutions

• Proven ability to quickly learn and utilize new methods, prototype instruments and technology

• Proven ability to manage multiple tasks, projects, and assignments simultaneously

EDUCATION

Ph.D. in Biological Engineering, University of Georgia, Athens, GA, Aug. 2008

•Worked in a multidisciplinary group to improve the design of nano/micro electrochemical biosensors

•Best Poster Award •Graduate Travel Funding Awards

MS in Biomedical Engineering, Zhejiang University, Hangzhou, China, Jul. 2004

•Graduate Scholarship recipient

BS in Medical Imaging, Taishan Medical College, Taishan, China, Jul. 2001

• President of 1996 class (~ 60 students)

•Deputy President of the Student Union of the Radiological Department (a size of around 500 people)

•Internship in the Fourth People’s Hospital, Jinan, China

SKILL SETS

Electrochemistry: Cyclic voltammetry, EIS, Amperometry, Potentiometry

Bioinstrumentation Powerlab, DSI ImplantableTelemetry, ISO-NO-WPI

Data acquisition: HP34970A data acquisition switch unit, Power meter

Bio-sample handling: Bio-molecule immobilization, Self-assembled monolayer formation

Material analysis: SEM, TEM, AFM, EDX, XRD, XPS, Mass spectrometry, Auger

Material preparation: Electroplating, Electro-less deposition, Anodization, Ball milling,

Semiconductor processing: Clean room, Physical vapor deposition, Photolithography, Wet etching

DNA sequencing High-throughput ISFET-based next-generation sequencing system

Fluidic systems: Electronically-controlled reagent delivery system, PDMS fluidic structures

Computer: Matlab, Large dataset analysis, LabView, Finite element analysis, CFD

Python, SolidWorks, Maple, MS Office, MS Windows, Linux

PROFESSIONAL EXPERIENCE

454 LIFE SCIENCES – A ROCHE COMPANY, Branford, CT

Research Scientist Dec. 2012 - May. 2013

Development of CMOS-based DNA sequencing platform

• Worked in an intense product development environment.

• Designed and implemented reference electrode assembly for the sequencer with demonstrated superior

stability.

• Optimized reagent delivery system with improved reagent mixing through experimental design and numerical

analysis on the fluidic manifold.

• Developed sequencing protocol and optimized its performance through improved electrochemistry.

• Explored, tested and integrated new hardware components to the instrumentation.

UNIVERSITY OF ILLINOIS, Urbana, IL 2008 - 2012

Postdoctoral Research Associate

Development of Direct Liquid Fuel Cell (DLFC)

• Improved the power density of DLFC up to 2 times by increasing the uniformity of catalytic layers and anodes

using both electro- and electroless- plating.

Xiaoling (Charlene) Yang, PhD *********@*****.*** Page Two of Three

UNIVERSITY OF ILLINOIS, continued

Design and development of nuclear power sources

• Designed and Developed Ultra-High-Vacuum system preventing convective heat loss and enabling residual

gas analysis using mass spectrometry.

• Fabricated metal alloy powders that produced 300% higher power density compared with conventional

methods.

• Demonstrated world’s first ultra-high energy deuterium ion source from laser-metal-interaction at Los Alamos

National Laboratory, which can be used for both medical therapy and hot fusion energy production.

Management

• Led hydrogen energy research group.

• Served as PI of DOE STTR Phase I project. Managed a $35k sub-award account.

• Successfully completed the proposed tasks, and reported the progress quarterly to DOE.

• Cut down the development cost of two ultra-high-vacuum systems by 50%.

• Managed multiple projects related to green energy sources.

THE UNIVERSITY OF GEORGIA – Athens, GA 2004 2004 - 2008

Research Assistant

Research and development of Electrochemical Biosensor

• Fabricated micro-array electrodes by physical vapor deposition, photolithography, and wet etching.

• Made ordered nanoporous structure by anodizing aluminum thin foil

• Made nanotubes and nanorods by electro-deposition into hard templates.

• Immobilized glucose oxidase enzyme or antigen on top of gold nanorods.

• Characterized the nanostructures by SEM, AFM, and TEM.

• Investigated the sensing performance of the fabricated glucose sensors and affinity sensors by various

electrochemical methods.

2-D and 3-D Numerical Modeling of electrochemical sensing devices (COMSOL)

• Characterized the performance of sensing electrodes by modeling mass transport and electrode kinetics

using finite element methods.

• Modeled the signal detection of glucose enzymatic reaction byproducts in microfluidic chambers.

ZHEJIANG UNIVERSITY, China 2001 - 2004

Research Assistant

Collection of bio-signals

• Collected the ECG and blood pressure of SD rats using Powerlab and DSI Implantable Telemetry.

• Collected concentration of Nitric Oxide using ISO-NO-WPI.

Signal Processing of Physiological data (Matlab)

• Quantified heart rate variability from ECG signal through FFT frequency domain analysis.

• Inferred blood pressure and Baroreceptor reflex sensitivity from pulse signals through regression analysis.

PROFESSIONAL ACTIVITIES

• Presented research findings 10 plus times in national and international conferences

• Drafted 15 plus STTR and other research proposals in response to DOE, DOD, and other funding agencies

• Patent: Dislocation site density techniques, U.S. Patent No. 8,440,165

• Supervised undergraduate independent research conducted by students, course lecturer, invited peer-reviewer

Xiaoling (Charlene) Yang, PhD *********@*****.*** Page Three of Three

SELECTED PUBLICATIONS

1. X. Yang and G. Zhang (2008), The effect of an electrical double layer on the voltammetric performance of nanoscale

interdigitated electrodes: a simulation study, Nanotechnology 19, 465504 (8pp)

2. X. Yang, G. Zhang (2007), The voltammetric performance of interdigitated electrodes with different electron-transfer

rate constants, Sens. Actuators B 126 624–631.

3. X. Yang and G. Zhang (2007), Simulating the Structure and Effect of the Electrical Double Layer at Nanometer

Electrodes, Nanotechnology 18 335201-8.

4. V. Anandan, X. Yang, et al. (2007), Kinetics of Mass Transport at the Active Nanoelectrode Arrays During Biosensing,

Journal of Biological Engineering 1:5.

5. X. Yang, G. Zhang (2007) Effect of Electrical Double Layer on the Performance of Nanometer Interdigitated

Electrodes, IEEE Sensors Conference Publications, 367-370

6. Z. Peng, P. J. Hesketh, X. Yang, G. Zhang (2007), Interdigitated Array Electrodes with Magnetic Function as a

Particle-Based Biosensor, IEEE Sensors Conference Publications, 1097 – 1100

7. N. Luo, X. Yang, G. Miley, K.J. Kim, J. F. Stubbins, X. Huang, R. L Burton (2009), In-situ preparation of catalytic

diffusion layers and its application in direct liquid fuel cells. FuelCell2009-85201, 7th International Fuel Cell Science,

Engineering & Technology Conference, Newport Beach, CA

8. K-J. Kim, R. Bernas, N. Luo, X. Yang and G. Miley (2009), A Novel Anode Electrode for Direct Borohydride Fuel Cell.

Clean Technology Conference & Expo, Huston, TX

9. X.Yang, G. H. Miley, K. A. Flippo, H. Hora (2012), Hot spot heating process estimate using a laser-accelerated quasi-

maxwellian deuteron beam, Laser and particle beams, 30(1): 31-38

10. X.Yang, G. H. Miley, K. A. Flippo, H. Hora (2011), Energy enhancement for deuteron beam fast ignition of a

precompressed inertial confinement fusion target, Physics of Plasmas, 18(3), 032703

11. X. Yang et al., (2011), D-Cluster Converter Foil for Laser-Accelerated Deuteron Beams: Towards Deuteron-Beam-

Driven Fast Ignition, Fusion Science and Technology, 60 (2), 615-619

12. H. Hora, G.H. Miley, K. Flippo, P. Lalousis, R. Castillo, X. Yang, B. Malekynia, M. Ghoranneviss, (2011), Review of

acceleration of plasma by nonlinear forces from picoseond laser pulses and block generated fusion flame in

uncompressed fuel, Laser and Particle Beams, 29, 353–363.

13. G. H. Miley and X. Yang, (2009), Deuterium cluster target for ultra-high density fusion, Fusion Science and

Technology, 56 (1), 395-400

14. L. Holmlid, H. Hora, G. Miley and X. Yang (2009), Ultrahigh-density deuterium of Rydberg matter clusters for inertial

confinement fusion targets, Laser and Particle Beams, 27, No. 3

15. G. Ning, X. Yang, H. Li, X. Zheng (2004), Modulation of baroreflex activity by exogenous and endogenous NO in SD

rats, Hangtian Yixue Yu Yixue Gongcheng/Space Medicine and Medical Engineering, v 17, n 6, p 391

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