Quality Control State University

SHILPA VASHIST

Contact Information:

Home Address: Plainsboro, NJ

Phone number: 732-***-****

e-mail: ******.*******@*****.***

Work eligibility: Permanent Resident (Green Card)

CURRENT POSITION

Freelance Editor (since 2012)

American Journal Experts

AMEditor

(Content review and editing for manuscripts in Cell and Molecular Biology, Genetics, Clinical

Microbiology, Neuroscience, Genomics, Proteomics, Metabolomics, Oncology, Alternative Medicine,

and Clinical Research)

Freelance Science Writer (since 2012)

Development of informational and educational content for Labome.com (anti-GFP antibody, anti-

polyhistidine antibodies and current approaches in C. elegans research), preparation of slides,

abstracts and summaries

AREAS OF EXPERTISE

Scientific expertise

Cell and Molecular Biology

Genetics

Microbiology

Neuroscience

Basic principles of Oncology

Basic knowledge of phases of drug development, clinical trials and regulatory requirements

Other areas

Extensive publication experience, having authored highly cited, peer-reviewed journal articles in Cell, Journal of

Cell Biology and Molecular Biology of the Cell

Reviewer for Biochemical and Biophysical Research Communications (BBRC), Journal of General

Microbiology and Journal of Biological Chemistry

Strong scientific background, skilled in analyzing and interpreting scientific research data

10 years of experience in writing and editing on a wide range of scientific topics for a variety of audiences

Extensive experience in presentation of scientific data at invited talks and poster presentations

Knowledge of AMA style guidelines

Excellent command of written English

RESEARCH/WORK EXPERIENCE

University of Pennsylvania School of Medicine, Philadelphia, PA

Research Fellow (2008 –2010)

Application of remodeling enzymes to protein-misfolding disorders and neurodegenerative disorders

(Alzheimer’s and Parkinson’s diseases)

Harvard Medical School and Massachusetts General Hospital, Boston, MA

Postdoctoral Fellow (2006 –2008)

Regulation and modulation of synapse function by micro RNAs (miRNAs) using genetic, biochemical, and

fluorescent imaging techniques

Rutgers, The State University of New Jersey

Senior Research Associate (2005 –2006)

Regulation of endocytic recycling in C. elegans

Yeast Protein Sciences, Inc. (YPS), CA (a start up, which spawned from my own research)

Research Scientist (2003)

Production of pharmaceutically useful, full-length properly folded human antibodies in yeast strains

EDUCATION

Colorado State University, Fort Collins, CO, USA (Extension)

- 2013 (ongoing): Regulatory affairs for the Pharmaceuticals and Biologics Industry

University of California, San Diego, CA, USA (Extension)

- 2012: Medical Writing: Protocols, Reports, Summaries and Submissions

- 2013: Understanding Oncology

The Pennsylvania State University, University Park, PA, USA

2004: Ph.D., Biochemistry and Molecular Biology

Dissertation title: Quality control of protein folding in the endoplasmic reticulum

Jawaharlal Nehru University, Delhi, India

1996: M.Sc. Biotechnology

Thesis title: Analysis of upstream regions of ApoE gene associated with artherosclerosis

University of Delhi, Delhi, India

1994: B.Sc. (Honors in Biochemistry)

PUBLICATIONS

Vashist S, Meinhardht N, Tammaro M, Shorter J. Variants of protein disaggregases, Hsp104 and ClpB

efficiently disassemble disease causing Abeta-amyloids associated with Alzheimer’s disease (Manuscript in

preparation)

DeSantis ME, Leung E, Sweeny EA, Jackrel ME, Cushman M, Neuhaus-Follini A, Vashist S, Sochor MA,

Knight MN, and Shorter J. Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Non-

Amyloid Clients. Cell. 2012, 151(4): 778-93

Vashist S, Cushman M, Shorter J. Applying Hsp104 to protein-misfolding disorders. Biochemistry and Cell

Biology. 2010, 88(1): 1-13

Chen CC, Schweinsberg PJ, Vashist S, Mareiniss DP, Lambie EJ, Grant BD. RAB-10 is required for endocytic

recycling in the Caenorhabditis elegans intestine. Molecular Biology of the Cell. 2006, 17(3): 1286-97

Vashist S and Ng DT. Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality

control. Journal of Cell Biology. 2004, 165(1): 41-52

Vashist S, Frank CG, Jakob CA, Ng DT. Two distinctly localized P-type ATPases collaborate to maintain

organelle homeostasis required for glycoprotein processing and quality control. Molecular Biology of the Cell.

2002, 13(11): 3955-66

Vashist S, Kim W, Belden WJ, Spear ED, Barlowe C, Ng DT. Distinct retrieval and retention mechanisms are

required for the quality control of endoplasmic reticulum protein folding. Journal of Cell Biology. 2001, 155(3):

355-68

John MV, Parwez I, Sivaram MV, Mehta S, Marwah N, Ali S. Analysis of VNTR loci in fish genomes using

synthetic oligodeoxynucleotide probes. Gene. 1996, 172(2): 191-7

AWARDS

Pennsylvania State University Wadler Outstanding Doctoral Dissertation Award 2004

Pennsylvania State University Alumni Association Dissertation Award 2002

American Society for Cell Biology (ASCB) Predoctoral student travel award 2002

Pennsylvania State University Braddock award 2000

Jawaharlal Nehru University Merit Fellowship 1994 -1996

University of Delhi Silver Jubilee Merit award 1992

INVITED TALKS

The Carnegie Mellon University Yeast Meeting, 2004

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control.

American Society for Cell Biology (ASCB) annual meeting minisymposium, 2002

Topologically distinct surveillance systems in ER quality control.

The Carnegie Mellon University Yeast Meeting, 2000

A transport and retrieval mechanism for misfolded proteins destined for ER-associated degradation.

The Penn State Intercampus Yeast Meeting, 1999

A novel UPR-regulated P-type ATPase required for secretory protein biogenesis and quality control.

PRESENTATIONS

American Society of Cell Biology Annual Meeting, 2003

ER quality control employs a sequential checkpoint mechanism for sorting misfolded proteins.

American Society of Cell Biology Annual Meeting, 2001

Collaboration of two distinct P-type ATPases in secretory protein biogenesis and quality control.

American Society of Cell Biology Annual Meeting, 2000

A transport and retrieval mechanism for misfolded proteins destined for ER associated degradation.

TEACHING EXPERIENCE

Teaching Assistant, Department of Biochemistry and Molecular Biology, Pennsylvania State University

Microbiology laboratory course for Honors students - Fall semester, 1999

Biochemistry laboratory course for undergraduates - Spring semester, 2000

Contact this candidate