Available Upon Request
Resume:
Alex K. Mathies, Ph.D.
Hubertus, WI 53033
Email: ***********@*****.***
Phone: 262-***-****
Highlights
. Optimized and scaled syntheses of a variety of compounds up to tens of
kilogram scale
. Developed master production records for GMP synthesis of API's
. Developed methodology in the areas of radical chemistry and O-silyl
protected carbinols additions to electrophiles
. Responsible for qualification of the Bruker 300 NMR for GMP usage.
. Conducted training of R&D, QC and QA on use of NMR for analysis.
. Completed the total synthesis of L-daunosamine
. Utilized radical cyclization methodology towards the synthesis of -
dysiherbaine
. Effective communicator with clients, colleagues, support staff and
plant staff.
Experience
Research Scientist 2 (Process Research and Development), Cambridge Major
Laboratories, Inc., Germantown, Wisconsin, Oct. 2007- Oct. 2013.
. Optimized synthesis of API's for kilogram scale
. Wrote master production records for GMP syntheses of API's
. Responsible for multiple projects simultaneously (up to 5) from lab
scale to overseeing plant production
. Independently involved in detailed discussions with clients
. Responsible for operation, shimming and maintenance of NMR
. Transferred to Process Research and Development and promoted to
Research Scientist 2 in 2010.
. Organized the qualification of the Bruker NMR including coordination
with Bruker engineers, oversight on the protocol generation and
execution.
. Written SOPs and test methods for NMR use.
. Chair of the CMPliance committee which in aimed at controlling CML's
environmental impact.
. Chair of the Safety Committee which is a inter-departmental group
aimed at identifying and solving employee safety concerns.
Postdoctoral Research Assistant, Northwestern University, Evanston, IL,
2006-2007.
. Professor Karl A. Scheidt research group
. Umpolung additions of acyl anion equivalents generated from
triethylsilyl carbinols and cesium fluoride
. Responsible for chemical safety
. Supervised and maintained glove box
Research Assistant, University of Iowa, Iowa City, IA, 2005-2006.
Research/Teaching Assistant, University of Vermont, Burlington, VT, 1999-
2005.
. 6-exo radical cyclization to chiral hydroxyhydrazones via a silicon-
tether
. Synthetic studies towards syntheses of -dysiherbaine and L-
daunosamine
. Directed chemical safety and training for fellow researchers
. Responsible for chemical inventory and ordering
. Supervised and maintained glove box, IR and HPLC
. Mentored graduate and undergraduate students
. Responsible for instructing laboratory for general chemistry and
organic chemistry
. Instructed chemistry majors, non-chemistry majors and non-science
majors students
. Organized supplementary review sessions for general and organic
chemistry
. Substitute lecturer for general, organic, inorganic and analytical
chemistry courses
Adjunct Faculty, University of New England, Biddeford, ME, 2004.
. Summer faculty position for organic chemistry
. Responsible for lecture and laboratory
Education
Doctor of Philosophy, University of Iowa, Iowa City, IA, 2006.
Advisor - Professor Gregory K. Friestad
Thesis: "Radical Cyclizations to Imino Acceptors Directed Toward the
Total Syntheses of Aminosugars."
Bachelor of Science, Norwich University, Northfield, VT, 1999.
Manuscripts
Mathies, A. K.; Mattson, A. E.; Scheidt, K. A. "Intermolecular Crossed-
Acyloin Reactions by Fluoride-Promoted Additions of O-Silyl Thiazolium
Carbinols," Synthesis, Invited Contribution to Special Edition for Journal
Awardees. 2009, 377-383.
Gregory K. Friestad; Alex K. Mathies "Effects of ?-Alkoxy Substitution and
Conformational Constraints on 6-exo Radical Cyclizations of Hydrazones via
Reversible Thiyl and Stannyl Additions." Tetrahedron 2007, 63, 9373-9381.
Gregory K. Friestad; Tao Jiang; Alex K. Mathies "Enhanced Reactivity in
Radical Cyclizations of Hydrazones Using the Silicon-Tethered 1-Bromovinyl
Group." Tetrahedron 2007, 63, 3964-3972.
Gregory K. Friestad; Tao Jiang; Alex K. Mathies "Aldehyde-Selective Wacker
Oxidation in a Thiyl-Mediated Vinyl Group Transfer Route to Daunosamine."
Org. Lett. 2007, 9, 777-780.
Gregory K. Friestad and Alex K. Mathies "Recent Developments in Asymmetric
Catalytic Addition to C=N bonds" Tetrahedron 2007, 63, 2541-2569.
Gregory K. Friestad; Tao Jiang; Alex K. Mathies; Sara E. Massari "The
Silicon-Tether Approach for Formal Acyclic Stereocontrol in Radical
Addition to Hydrazones." Phosphorus, Sulfur and Silicon and the Related
Elements 2004, 179(4-5), 955-956.
Presentations at Scientific Meetings
Alex K. Mathies; Anita E. Mattson; Karl A. Scheidt "Nucleophilic
Acylations Using Thiazolium Carbinols: A Fluoride-promoted Umpolung
Strategy for Base-sensitive Acceptors." 234th American Chemical Society
National Meeting, Boston, MA, August 19-23, 2007, Oral presentation.
Alex K. Mathies; Gregory K. Friestad; Tao Jiang "Radical cyclizations to
imino acceptors - towards the total syntheses of aminosugars." 37th Great
Lakes Regional Meeting of the American Chemical Society, Milwaukee, WI,
May 31-June 2, 2006, Poster Presentation.
Alex K. Mathies; Gregory K. Friestad "Silicon-Tethered 6-Exo Radical
Cyclizations of Imino Radical Acceptors." National Organic Symposium,
Bloomington, IN, June 18-20, 2003, Poster Presentation.
Gregory K. Friestad; Tao Jiang; Alex K. Mathies; Sara E. Massari "Silicon-
Containing Heterocycles in Stereocontrolled Radical Additions to Chiral
Hydrazones." IRIS X: The 10th International Symposium on Inorganic Ring
Systems, Burlington, VT, August 17-21, 2003, Poster Presentation.
Gregory K. Friestad; Sara E. Massari; Gina M. Fioroni; Alex K. Mathies
"The Silicon-Tether Approach for Formal Acyclic Stereocontrol in Radical
Addition to Hydrazones." Humphrey Symposium, Burlington, VT, September
2002, Poster Presentation.
Skills
. 1H NMR (including NOE difference, NOESY and COSY), 13C NMR (including
DEPT), 31P NMR, 19P NMR, FT-IR, GC, GC-MS, HPLC, optical rotation, TGA
and DSC.
. Multi-step synthesis, asymmetric synthesis, metal catalyst
preparation.
. Inert atmosphere conditions: use of glove box (responsible for
maintenance); bench top controlled atmosphere.
. Good communication skills and the ability to work well with others.
. Able to supervise group effectively.
. Microsoft Word, Excel, PowerPoint, Beilstein, SciFinder, Isis Draw,
MestReC, ChemDraw and Chem3D.
Teaching Awards
. Senior Teaching Assistant Award, University of Vermont, Burlington,
VT, 2002.
. Graduate Student Summer Stipend Award, The Center for Teaching and
Learning, University of Vermont, Burlington, VT, 2000.
. First Year Teaching Assistant Award, University of Vermont,
Burlington, VT, 2000.
Chemistry Outreach
Graduate Student Liaison, University of Vermont Chemistry Club, 2002-2005.
. Organized demonstrations for local high schools.
. Organized demonstrations for 8th grade students from Boston (Spring
2002, 2003, 2004).
. Organized demonstrations for 1st - 3rd grade students at the
Colchester Science Camp (Summer 2002, 2003).
Treasurer, Norwich University Chemistry Club, 1998-1999.
. Organized weekly meetings with science majors to discuss literature in
all fields of science.
. Invited faculty from the University of Vermont to give a series of
lectures.
. Organized demonstrations for the Vermont Science Fair (Spring 1998,
1999).
Recommendations
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