Yuhua "Hugh" Zhang

Permanent Resident (Green Card holder)

*** ***** **** **., ******, CT 06518; 504-***-**** (cell);

ab8z37@r.postjobfree.com

I. QUALIFICATIONS AND SKILLS

Strong experiences in Organic, Analytical and Inorganic Chemistry:

1. Strong experiences in operation, calibration, and trouble shootings with

LC/MS (Waters 2790; Varian 500MS), GC/MS(Varian Saturn 2200),

GC/FID(Varian CP-3800), HPLC/UV(Schimazu), FT-IR, Viscometer, pH meter,

and other equipments in chemical laboratory.

2. Multiple-step organic synthesis, retro-synthetic analysis, new reaction

methodology, and identification of unknown compounds by various

spectroscopic methods (1D/2D NMR, MS, IR, UV etc.), identification of

reaction mechanism, organic synthesis and separation skills.

3. Strong experience in analytical method R&D for active ingredients in OTC

cosmetic products with LC/MS and GC.

4. Experience at Kilogram-scale reactions; Low-temperature and high-

pressure techniques.

5. Strong oral and written communication skills.

II. EMPLOYMENT

1/2012 - 8/2012 Synthetic Chemist in Organic Chemistry

Aris Pharmaceutical, Inc., Ewing, NJ

1) Customer Organic Synthesis / Process Development in the

pharmaceutical/chemical industry.

2) Operated and maintained laboratory instrument Water 2790

LC/MS.

6/2009 - 7/2011 Research Chemist in Analytical Chemistry

MW LABS, Inc., Savannah, GA

1) Developed and validated analytical methods to test active

ingredients in OTC cosmetic products;

2) Prepared method validation protocol, method validation

report and SOPs by following ICH regulations;

3) Operated and maintained laboratory instruments including

Varian LC/500-MS, Varian CP-3800 GC, Bruker ALPHA FT-IR, pH

meter, and Viscometer.

10/2007 - 6/2009 Postdoc Research Associate in Organic Chemistry

Department of Chemistry, Washington University in St. Louis,

St. Louis, MO

1) Designed and asymmetrically synthesized new bicyclic

imidines and isothiazoleurea compounds; developed the fourth

generation of amidine-based catalysts for enantioselective

acyl transfer catalysis.

2) Improved their asymmetric catalyses in kinetic resolution of

racemic alcohols and related organic reactions (for example,

steglich rearrangement) by using Shimazu HPLC/UV.

12/2003 -10/2007 Postdoc Research Associate in Organic Chemistry

Department of Chemistry, Tulane University, New Orleans, LA

1) Accomplished new cross-dehydrogenative-coupling reactions by

using GC/MS, established the shortest route to form the key

intermediate of some specific oxygen-containing natural

products from simple organic compounds;

2) Developed a neat Au(III)-catalyzed tandem synthesis of N-

vinyl indole.

3) Found out a microwave-promoted direct addition of ether to

alkyne compounds.

8/2001 - 12/2003 Assistant Professor in Organic/organometallic Chemistry

Lanzhou Institute of Chemical Physics, Chinese Academy of

Sciences, China

1) Designed and synthesized novel organometallic clusters

containing Cobalt, Nickel and other transition metals;

2) Developed a simple procedure to prepare organometallic

macromolecules.

9/1996 - 7/2001 Graduate Research Assistant in Organic/organometallic

Chemistry

Lanzhou Institute of Chemical Physics, Chinese Academy of

Sciences, China

1) Developed three methods to asymmetrically synthesize chiral

metal cluster complexes;

2) Designed and synthesized novel organometallic clusters

containing Cobalt, Ruthenium, Iron, Molybdenum and etc.

III. EDUCATION

1996 - 2001 Ph.D. in Organic/organometallic Chemistry

Lanzhou Institute of Chemical Physics, Chinese Academy of

Sciences, China

1992 - 1996 B.S. in Chemistry

Shandong Normal University, China

IV. AWARDS AND AFFILIATIONS

1. The Outstanding Award honored by the Chinese Academy of Sciences'

President in 2002.

2. The Top-class Peng Yingang Scholarship, Chinese Academy of Sciences in

2001.

3. The Outstanding Graduate of the Year, Shandong Normal University in

1996.

4. Member of the American Chemical Society since 2004.

V. REPRESENTATIVE PUBLICATIONS

1. Yuhua Zhang, Vladimir B. Birman, Effects of methyl substituents on the

activity and enantioselectivity of homobenzotetramisole-based catalysts

in the kinetic resolution of alcohols, Adv. Synth. Catal., 2009, 351,

2525.

2. Woo-jin, Yoo, Camille A, Correia, Yuhua Zhang, Chao-Jun Li, Oxidative

alkylation of cyclic benzyl ethers with malonates and ketones, Synlett,

2009, 138.

3. Yuhua Zhang, Jianqing Feng, Chao-Jun Li, Palladium-catalyzed methylation

of aryl C-H bond by using peroxides, J. Am. Chem. Soc., 2008, 130(10),

2900.

4. Yuhua Zhang, Chao-Jun Li, Highly efficient direct alkylation of

activated methylene by simple alkanes, Eur. J. Org. Chem., 2007, 4654.

5. Carolyn S. Reid, Yuhua Zhang and Chao-Jun Li, Fluorous-Tag: An enabling

isolation technique for indium-mediated allylations reactions in water,

Org. & Biomol. Chem., 2007, 5(22), 3589.

6. Yuhua Zhang, James P. Donahue, Chao-Jun Li, Highly efficient double

hydroaminition of ortho-alkynylaniline with terminal alkynes leading 1-

alkene indoles, Org. Lett., 2007, 9, 627.

7. Yuhua Zhang, Chao-Jun Li, Highly efficient cross-dehydrogenative-

coupling between ethers and active methylene compounds, Angew. Chem. Int.

Ed., 2006, 45, 1949.

8. Yuhua Zhang, Chao-Jun Li, DDQ-meidated direct cross-dehydrogenative-

coupling (CDC) between benzyl ethers and single ketones, J. Am. Chem.

Soc., 2006, 128, 4242.

9. Xiao-Fan Yang, Mingwen Wang, Yuhua Zhang, Chao-Jun Li, 2.4-

Diaryltetrahydropyran formation by the Prins cyclization and its

application towards the synthesis of Epicalyxin F and Calyxin I, SynLett,

2005, 12, 1912.

10. Yuhua Zhang, Chao-Jun Li, Microwave-assisted direct addition of

cycloethers to alkynes, Tetrahedron Lett., 2004, 45, 7581.

11. Quan-Yi Zhao, Yu-Hua Zhang, Bin Hu, Wei-Qiang Zhang, Bao-Hua Zhu, Yuan-

Qi Yin, Chun-Gu Xia, Asymmetric inducing synthesis of optically active

tetrahedral cluster containing SMCoW core, Chin. J. Chem., 2004, 22(7),

757.

12. Quan-Yi Zhao, Wei-Qiang Zhang, Yu-Hua Zhang, Bin Hu, Yuan-Qi Yin, Chun-

Gu Xia, Synthesis of optically active tetrahedral clusters through ester

exchange catalyzed by lipase, Organomet., 2004, 23(4), 817.

13. Yu-Hua Zhang, Pu Liu, Chun-Gu Xia, Bin Hu, Yuan-Qi Yin, Study of metal

exchange reactions in cobalt containing clusters, J. Organomet. Chem.,

2003, 676(/1-2), 55.

14. Zhang Yu-Hua, Li Qing-Shan, Xia Chun-Gu, Yin Yuan-Qi, Zhou Zhong-Yuan,

Chen Xin-Zi, Synthesis and characterization of new linked clusters, Chem.

J. Chin. Univ., 2002, 23(8), 1515.

15. Zhang Yu-Hua, Hu Bin, Xia Chun-Gu, Chen Zhi, Yin Yuan-Qi, Synthesis and

characterization of dipropargyl esters, Chin. J. Syn. Chem., 2002, 10(4),

335.

16. Zhang Yu-Hua, Yuan Jian-Chao, Yin Yuan-Qi, Zhou Zhong-Yuan, Albert S.

C. Chan, Synthesis and reactions of chiral clusters containing an SRuCoMo

core, New J. Chem., 2001, 25, 939.

17. Yu-Hua Zhang, Jian-Chao Yuan, Wen-Jian Lao, Yuan-Qi Yin, Zi-Xiang Huang

and Jiang-Jin Wu, Synthesis, characterization and reactions of cluster

complexes containing SeRuCoM (M = Mo or W) core and a functionally

substituted cyclopentadienyl ligand, J. Organomet. Chem., 2001, 628(1),

123.

18. Yu-Hua Zhang, Wen-Jian Lao, Yue-Qi Liu, Yuan-Qi Yin, Jiang-Jin Wu and

Zi-Xiang Huang, Reactions of dipropargyl manolate, terephthalate with

Co2(CO)8, Mo2Cp2(CO)4 and RuCo2(CO)11 give the di or tetranuclear

clusters. The crystal structure of [CH2(CO2CH2C2H- 2][Co2(CO)6]2 and [p-

(HC2CH2OCO)C6H4(CO2CH2C2H- ][Co2(CO)6], Polyhedron, 2001, 20(9-10),

1107.

19. Yu-Hua Zhang, Jian-Chao Yuan, Yuan-Qi Yin, Zhong-Yuan Zhou and Albert

S. C. Chan. Preparation and reactions of tetrahedrane-type clusters

containing a SCoFeM (M = Mo or W) core. The single crystal X-ray

structure of the cluster ((3-S)CoFeMo(CO)8[(5-C5H4C(O)CH2CH2CO2Me],

Polyhedron, 2001, 20(15-16), 1859.

20. Yu-Hua Zhang, Chun-Gu Xia and Yuan-Qi Yin, Attempts to resolute metal

clusters with chiral framework by optically active hydrazides, Inorg.

Chim. Acta, 2001, 325(1-2), 198.

21. Yu-Hua Zhang, Xue-Nian Chen, Jie Zhang, Yuan-Qi Yin*, Jiang-Jin Wu and

Zi-Xiang Huang, "Reactions of dipropargyl oxalate with Co2(CO)8,

RuCo2(CO)11 and crystal structure of (COOCH2C2H- 2[Co2(CO)6]2", J. Chem.

Res(S), 2000, 8, 378-378.

22. Zhang Yu-Hua, Wu Shu-Lin, Li Qing-Shan, Yin Yuan-Qi, Asymmetric

synthesis of mixed metal clusters induced by phase-transfer catalysts, J.

Mol. Cat. (China), 2001, 15(2), 134.

23. Zhang Yu-Hua, Xu Yi, Chen Min-Dong, Zhu Xin-Yi, Chen Zhi, Yin Yuan-Qi,

Resolution of chiral metal clusters catalyzed by lipase, J. Mol. Cat.

(China), 2000, 14(2), 151.

24. Jie Zhang, Yu-Hua Zhang, Xue-Nian Chen, Er-Run Ding, and Yuan-Qi Yin,

Regioselective metal exchange reactions in linked clusters, Organomet.,

2000, 19, 5032.

VI. REFERENCES

References will be provided upon request.

Contact this candidate