Process Manager

Seung-Yong Choi Ph.D.

**** ******* ***** *****

Kernersville, NC 27284

336-***-**** (mobile) ********@*****.***

Subject: Application for chemical research scientist/process development

chemist position.

Dear Sir/Madam:

I am writing this letter to join your company as an organic chemist. I

was working for PharmaCore, High Point, NC since Oct 2000 until Mar 2013.

During my employment at PharmaCore, I have made significant contribution in

R&D, process development and taking some of those projects from GLP to cGMP

in the pilot plant for various pharmaceutical companies some of which

allows them to scale up to multi-kg. I have had the opportunity to work on

control substance for our clients as well.

During the last 12 years of professional experience, I have had the

privilege of working as Sr. Principal Scientist/Group Leader at PharmaCore

where I take the responsibility of production of building blocks, custom

synthesis, FTEs and its bulk API intermediates. I also handled all

customer technical questions, mentor production group and the pleasure of

dealing with custom synthesis and contract FTE research.

Before coming to PharmaCore in 2000, I worked as a post-doctoral

fellow with Prof. Martin E. Newcomb (currently University of Illinois at

Chicago, IL) and the late Prof. Sir Derek H. R. Barton (the 1969 Nobel

Laureate in Chemistry at Texas A&M University) in the areas of organic

chemistry, enzymatic hydrocarbon oxidation, and synthetic methodology.

During the course of my Ph.D. program at Wayne State University and

Texas A&M University, I have been trained as a synthetic organic chemist

and bioorganic chemist worked on the hypersensitive radical clock and its

application to enzymatic system.

With these experiences, I am looking for a research scientist or

process chemist position, which emphasizes creativity, analytical skills

and knowledge in developing new targets of pharmaceutical application.

I would appreciate working in your company and value the opportunity

to discuss my qualifications and potential with you.

Sincerely,

Seung-Yong Choi

Seung-Yong Choi Ph.D.

7616 Charles Place Drive

Kernersville, NC 27284

336-***-**** (mobile) ********@*****.***

SUMMARY

Ph.D. synthetic organic chemist with extensive hands-on medicinal

chemistry, multi-step synthesis, process development and scale-up of

pharmaceutical chemicals, and management experience with multiple projects

while working in cross-functional teams with analytical science, process

safety, pharmaceutical API's, and pilot plant groups.

RESEARCH/WORK EXPERIENCE

PharmaCore, High Point, NC Chemical Research and Development (CRD)

. Senior Principal Scientist/Group Leader (Apr 2012 - Mar 2013)

. Principal Scientist /Group Leader (Feb 2002 - Mar 2012)

. Senior Research Scientist (Oct 2000 - Jan 2002)

1. Focus on leading research teams developing early/late process projects

to scale up in the pilot plant

2. Group leader with direct supervision of multiple chemists

3. Responsibilities include: project leadership, laboratory synthesis,

supervision of laboratory activities, creating and optimizing novel

synthetic routes to enable delivery of intermediates and API's

(GLP/cGMP processes) including timely completion of delivery and

technical reports

4. Comfortable working at any scale of multi-step synthesis of

biologically active small molecules and scale-up of pharmaceutical

chemicals (mg to multi-kg)

5. Experience setting up a 20-50L and 100L glassware lab for mid-scale

synthesis

6. Utilization of high throughput reaction screening to enable route

development for a customer

7. Isolation and characterization of key process intermediates and

impurities from bulk API chemicals

8. Custom organic synthesis/process development for gram, multi-kg, multi-

step, cGMP synthesis of API

9. FTEs research with big pharmaceutical and biotech companies

10. Significant contribution of designing building blocks (>1000 molecule)

and production of multi-million sales

Wayne State University, MI (Advisor: Professor Martin E. Newcomb)

. Postdoctoral Research Fellow/Group Leader (Sep 1996 - Sep 2000)

1. Design and Synthesis of Biologically Active Radical Precursors and

Applications of Hypersensitive Mechanistic Probes by Enzymatic Systems

(Cytochrome P450 / Methane monooxygenase)

Texas A&M University, TX (Advisor: Professor Sir Derek H. R. Barton, Nobel

Laureate in Chemistry in 1969)

. Postdoctoral Research Fellow (Sep 1994 - Aug 1996)

1. New synthetic methods with steroids and carbohydrates by Me3Al and

manganese catalytic oxidations

2. Industrial project experience of metal catalytic oxidations

(Detergents and Dye). This work was in collaboration with Unilever Co.

EXPERTISE SKILLS

. Design and synthesis of biologically active compounds and pharmaceutical

intermediates

. Crystallization, column purification, trouble shouting, structural

elucidation of organic compounds

. Analytical instrumental (HPLC, LC/MS, GC/MS, NMR, FT-IR, DSC, Karl

Fisher, XRPD, Laser Flash Photolysis)

SPECIALIZED TRAINING/PROFESSIONAL COURSES

. Completed courses of cGMP requirement for multi-disciplinary teams

. Completed courses of "Practical Process Research and Scale-up" by a

concentrated program on chemical process development of drug candidate

and intermediates, presented by Neal G. Anderson, July 26-27, 2002.

. Completed courses of Heterocyclic Chemistry- Concepts, Synthesis &

Applications presented by Peter Wipf, May 16, 2005.

. Completed courses of "Secrets of Batch Process Scale-Up" (Ensuring

Effective Translation of Laboratory Processes to Pilot Plant Scale) by

Scientific Update, October, 2007.

. Completed the Certificate of "Management and Leadership Strategies/

Bullet Proof Manager" by Crestcom International, Ltd. March - June, 2008

. 2010 Chemistry Nobel Prize Winner (Prof. Ei-ichi Negishi at Purdue

University) Spoke at PharmaCore Chemistry Symposium, June, 2011

. Completed the Certificate of "Project Management Fundamentals" by New

Horizons April 3, 2012

EDUCATION

9/91- 8/94 Ph.D. Organic Chemistry, Wayne State University, Detroit, MI

48202 Advisor: Professor Martin E. Newcomb

9/89 - 8/91 Texas A&M University, College Station, TX 77843

Advisor: Professor Martin E. Newcomb (Lab was

transferred to Wayne State University)

3/83 - 2/85 M.S. Organic Chemistry, Inha University, South Korea

Advisor: Professor Sung Soo Kim

3/79 - 2/83 B.S. Chemistry, Inha University, South Korea

HONOR

. R. Welch Fellowship at Texas A&M University (1989-1990)

. Korean Science and Engineering Foundation Award (1984-1985)

PUBLICATIONS

1. "The Reality of Polar Transition States in Photobromination of Toluenes

by N-Bromosuccinimide (NBS)" S. S. Kim, S.-Y. Choi, and C. H. Kang J.

Am. Chem. Soc. 1985, 107, 4234-4237.

2. "Comparative Hammett Studies of Imidoyl, Benzylic, and Aldehydic

Hydrogen Atom Transfer Reactions by t-Butoxy Radical" S. S. Kim, H. M.

Koo, and S.-Y. Choi. Tetrahedron Lett. 1985, 26, 891-894.

3. "Reinvestigation of a Criticized Mechanistic Probe Study of Metal

Hydride Reductions of Alkyl Halides" M. Newcomb, T. R. Varick, and S.-

Y. Choi. J. Org. Chem. 1992, 57, 373-378.

4. "Picosecond Radical Kinetics. Bond Cleavage of the Cubylcarbinyl

Radical" S.-Y. Choi, P. E. Eaton, M. Newcomb, and Y. C. Yip. J. Am.

Chem. Soc. 1992, 114, 6326-6329.

5. "Ethoxycarbonyl Acceleration of Cyclopropylcarbinyl Radical Ring

Opening" M. Newcomb and S.-Y. Choi. Tetrahedron Lett. 1993, 34, 6363-

6364.

6. "Picosecond Radical Kinetics. Alkoxycarbonyl Accelerated

Cyclopropylcarbiny Radical Ring Opening" S.-Y. Choi and M. Newcomb.

Tetrahedron 1995, 51, 657-664.

7. "Regiochemical Variations in Reactions of Methylcubane with tert-

Butoxyl Radical, Cytochrome P-450 Enzymes and a Methane Monooxygenase

System" S.-Y. Choi, P. E. Eaton, P. F. Hollenberg, K. E. Liu, S. J.

Lippard, M. Newcomb, D. A. Putt, and S. P. Upadhyaya, and Y. Xiong. J.

Am. Chem. Soc. 1996, 118, 6547-6555.

8. "An Efficient Rearrangement of Secondary Alkyl S-methyl Xanthate by

Trimethylaluminum (TMA)" D. H. R. Barton and S.-Y. Choi. Tetrahedron

Lett. 1996, 37, 2695-2698.

9. "Oxidation of Phenylhydrazones with Benzeneseleninic Anhydride (BSA): A

New Mechanistically Interesting Observation" D. H. R. Barton, S.-Y.

Choi, and W. Liu, and J. A. Smith Molecules Online 1998, 2, 22-28.

10. "Evidence for a Higher Oxidation State of Manganese in the Reaction of

Dinuclear Manganese Complexes with Oxidants" D. H. R. Barton, S.-Y.

Choi, B. Hu, and J. Smith. Tetrahedron 1998, 54, 3367-3386.

11. "Absence of Diffusively Free Radical Cation Intermediates in Reactions

of b- (Phosphatoxy)alkyl Radicals " S.-Y. Choi, D. Crich, J. H. Horner,

X. Huang, F. N. Martinez, M. Newcomb, D. J. Wink, and Q. Yao J. Am.

Chem. Soc. 1998, 120, 211-212.

12. "Absolute Rate Constants for a-Amide Radical Reactions" O. M. Musa, S.-

Y. Choi, J. H. Horner, and M. Newcomb. J. Org. Chem. 1998, 63, 786-

793.

13. "Picosecond Radical Kinetics. Fast Ring Openings of Secondary and

Tertiary trans-2-Phenyl cyclopropylcarbinyl Radicals" S.-Y. Choi, P. H.

Toy, and M. Newcomb. J. Org. Chem. 1998, 63, 8609-8613.

14. "Dimethyldioxirane Hydroxylation of a Hypersensitive Radical Probe:

Supporting Evidence for an Oxene Insertion Pathway" P. A. Simakov, S.-

Y. Choi, and M. Newcomb. Tetrahedron Lett. 1998, 39, 8187-8190.

15. "Adjusting the Top End of the Alkyl Radical Kinetic Scale. Laser Flash

Photolysis Calibrations of Fast Radical Clocks and Rate Constants for

Reactions of Benzeneselenol" M. Newcomb S.-Y. Choi, and J. H. Horner.

J. Org. Chem. 1999, 64, 1225-1231.

16. "Concerted b-(Phosphatoxy)alkyl and b-(Acyloxy)alkyl Radical Migrations

Studied by Laser Flash Photolysis" S.-Y. Choi, D. Crich, J. H. Horner,

X. Huang, and M. Newcomb. Tetrahedron 1999, 54, 3317-3326.

17. "Picosecond Radical Kinetics. Rate Constants for Ring Openings of 2-

Aryl-Substituted Cyclopropylcarbinyl Radicals" M. Newcomb, S.-Y. Choi,

and P. H. Toy. Can. J. Chem. 1999, 77, 1123-1135.

18. "Cationic Species Can Be Produced in Soluble Methane Monooxygenase-

Catalyzed Hydroxylation Reactions; Radical Intermediate Are Not Formed"

S.-Y. Choi, P. E. Eaton, D. A. Kopp, S. J. Lippard, M. Newcomb, and R.

Shen. J. Am. Chem. Soc. 1999, 121, 121**-*****.

19. "Cytochrome P-450 Catalyzed Hydroxylation of Mechanistic Probes that

Distinguish Between Radicals and Cations. Evidence for Cationic but

Not for Radical Intermediate" M. Newcomb, R. Shen, S.-Y. Choi, P. F.

Hollenberg, Alfin D. Vaz, and M. J. Coon. J. Am. Chem. Soc. 2000, 122,

2677-2687.

20. "Laser Flash Photolysis Measurements of the Kinetics of Ring Opening of

the (2,2)-Diphenylcyclobutylcarbinyl Radical" S.-Y. Choi, J. H. Horner,

and M. Newcomb. J. Org. Chem. 2000, 65, 4447-4449.

21. "Models of DNA C1' Radicals. Structural, Spectral, and Chemical

properties of the Thyminylmethyl Radical and the 2'-Deoxyuridin-1'-yl

Radical" C. Chatgilialoglu; C. Ferreir; R. Bazzanini; M. Guerra; S. -Y.

Choi; C. J. Emanuel; J. H. Horner; M. Newcomb. J. Am. Chem. Soc.

2000, 122, 9525-9533.

22. "Laser Flash Photolysis Studies of Alkoxyl Radical Kinetics Using 4-

Nitrobenzenesulfenate Esters as Radical Precursors" J. H. Horner, S.-Y.

Choi, M. Newcomb. Organic Letters. 2000, 2, 3369-3372.

PATENTS

1. "Amino Acid Derivatives" 2003. Alla, S.; Choi, S.-Y.; Condeiu, C.;

Dhanoa, D.; Difranco, D.; Krokhina, G.; Li, K; Thiagarajan, B.; Zhang,

W. Patent Number WO 03/010130 A1 issued June 02, 2003.

2. "Synthesis and Method of Purification of Cyclic Nucleoside Derivative"

2004. Chait, E.; Choi, S.-Y. Patent Number 0186282 A1 issued

September 23, 2004.

PRESENTATIONS

1. S.-Y. Choi, P. E. Eaton, M. Newcomb, and Y. C. Yip "Picosecond Radical

Kinetics. Bond Cleavage of the Cubylcarbinyl Radical" ACS, 25th Great

Lakes Regional Meeting, Milwaukee, June 1-3, 1992.

2. S.-Y. Choi, M. Newcomb, P. F. Hollenberg, D. A. Putt, and P. E. Eaton,

"Methylcubane a Potential Mechanistic Probe for Enzyme Oxidations" ACS

Joint 26th Central and 27th Great Lakes Regional Meeting, Ann Arbor,

June 1-3, 1994.

3. S.-Y. Choi, M. Newcomb, "Fast Radical Ring Openings of Substituted Aryl

Cyclopropylcarbinyl Radicals" Gordon Research Conference, Holderness

School, NH. July 13-17, 1997.

4. S.-Y. Choi, R. Shen. D. A. Kopp, P. E. Eaton, P. F. Hollenberg, A. D.

A. Vaz, M. J. Coon, S. J. Lippard, and M. Newcomb,"Oxidation of

Methylcubane with Cytochrome P-450 Enzymes and Methane Monooxygenase

Systems" ACS National Meeting, San Francisco, CA. Mar 26-30, 2000.

5. S.-Y. Choi, John H. Horner, and Martin Newcomb, Kinetic Studies of Ring

Opening of the 2,2-Diphenylcyclobutylcarbinyl Radicals by Laser Flash

Photolysis 8th International Symposium on Organic Free Radicals, June

25-29, 2000. University of Michigan, Ann Arbor, MI.

REFERENCE

Dr. M. Newcomb Dr. Joe Miller

Distinguished Prof. Department of Chemistry Sr. Vice President

University of Illinois at Chicago PharmaCore Inc.

Chicago, IL 60607 336-***-****

312-***-**** Fax 312-***-**** ************@***.***

***@***.***

Dr. Elso DiFranco Dr. Joseph Swaroop Mathen

Director, Chemical R&D Associate Director

PharmaCore Inc. PharmaCore Inc.

336-***-**** EXT 109 336-***-**** EXT 107

*********@**********.*** ********@**********.***

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