Project Development

Professional Profile

Highly accomplished, quick learner with an impressive hands-on knowledge

base encompassing the entire spectrum of Organic chemistry, with special

expertise in Medicinal chemistry and analytical solutions. Regarded by

peers and mentors and an overachiever who is committed to excellence in

this field, as demonstrated by outstanding academic achievement.

Demonstrate thorough and detailed research capabilities. Core competencies

include:

Skilled in Multistep Organic Expert in Separation, purication Motivated individual

Synthesis and Presentation skills

7+ years of experience in drug Characterization Mentoring experience

development Skilled in Analytical Interpersonal skills

Knowledge in diverse therapeutic instrumentation Communication skills

areas HPLC, GC-MS, NMR, FT-IR, SFC, Well versed with

Expert in interpretation of SAR ESI-MS, LC-MS, H-Cube & Parr GLP, OSHA, CHP

data and designing new analogs Highly Experienced with HPLC and PPE

(SBDD) purification and method

Hands on experience with Scale up development

of key intermediates & final Handled multiple projects and

compounds meet deadlines

Summary of Qualifications

Organic/ Medicinal Chemistry Skills

. More than seven years of experience in multistep synthesis of organic

compounds

. Knowledge of developing new chemistry, improving existing chemistry

and demonstrating the process by delivering compounds at expected

purity and batch size for the appropriate phase of development.

. Design and perform synthetic organic experiments efficiently and

independently.

. Generate effective hypothesis to pursue synthesis or manufacturing

goals and set new experimental direction

. Track record of solving chemical problems and scaling-up quantities of

compounds or intermediates in the appropriate physical form.

. Reactions handled include air & moisture sensitive, oxidation,

reduction, organometallics etc.

. Extensive experience of Pharmacokinetic analysis of drug compounds by

in vitro/in vivo PK for clinical development.

. Highly experienced MS Office, PC, Mac, Chemdraw, SciFinder, share

point and Reaxys

. Strong troubleshooting, problem solving and multi-tasking skills.

Professional Experience

Postdoctoral Research Scientist, ST. JUDE CHILDREN'S RESEARCH HOSPITAL -

Memphis, TN 2010-2013

Mentor: R. Kiplin Guy, Chairman and Member, Chemical Biology and

Therapeutics

Responsible for performing synthesis, purification and analysis of novel

anti-cancer agents.

. Synthesized novel analogs of CP466722 and investigated their activity

against Cancer

. Developed Structure Activity Relationships (SAR) to improve PK

properties

. New analogs improved potency, metabolic stability and kinase

selectivity

. Optimized synthesis for the large scale production of key compounds

for parallel synthesis

. Ensure compliance of laboratory safety principles, including OSHA, CHP

and PPE

Postdoctoral Research Scientist, UNIVERSITY OF WASHINGTON - Seattle, WA

Mentor: Michael H. Gelb, Professor Department of Chemistry & Biochemistry

Performed multi-step synthesis, purification, documentation and spectral

interpretation of NCEs for Malaria and American trypanosomiasis (Changas

disease).

Project 1: Design and synthesis of THQ based Pf-PFT inhibitors as potential

Anti-malarial agents 2005- 2007

Project 2: Synthesis of 2-Oxo-tetrahydro-1,8-naphthyridine- Protein

Farnesyltransferase Inhibitors 2007- 2008

Project 3: Synthesis of Lanosterol 14?-demethylase inhibitors against

Chagas disease 2008- 2010

Highlights:

. Synthesized over 200 diverse chemical compounds for SAR development

. New analogs showed dramatic improvements in potency, metabolic

stability and oral bioavailability

. Optimized the synthesis and scaled up 2 compounds for dog toxicology

studies

. Work highlighted in 14 drug discovery review articles as cost

effective synthesis

. Mentored graduate student Sarah McGuffin ("Testing the solubility of

drug like compounds")

. Maintained laboratory equipment (HPLC, Dry solvent systems) &

Laboratory safety

. Work published in JMC-2009; BMCL-2008; JMC-2007 & Conference Abstracts

& Entrepreneur Award-SEBA 2008

Ph.D Senior Research Fellow (Organic Chemistry, Natural Products)

INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY - Hyderabad, India

2000-2005

Dissertation: Studies and some bioactive natural products and development

of novel synthetic methodologies using Lewis acids as catalysts.

. Isolation and Synthesis of Lignan based anti-cancer compounds

(Clinical progression at Indigene pharma)

. Synthesized -Carinol analogs as potential xanthine oxidase enzyme

inhibitors

. Developed novel synthetic protocols using Lewis acids (Bi(OTf)3, PTSA,

H3PW12O40)

. Expert in structural determination of complex natural products using

1D & 2D NMR techniques

. Work published in JAFC-2001, JPC-2002, Chem.Lett.-2003, JCR-2004, Syn.

Comm-2005, PCT-WO2007 & EP-2008

Analytical Experience

. Experience in the operation, calibration and maintenance of laboratory

equipment and analytical instrumentation, including NMR, IR, UV/Vis,

HPLC, SFC, GC-MS, LC/MS/MS, Centrifuge, Lyophilizer, TLC, Combiflash

and Biotage.

. Highly experienced with the purification of compounds using HPLC.

. Skilled in analysis & interpretation of compounds using UPLC & MS,

reaction monitoring, yields and purity.

. Interpretation of spectroscopic data via FT-IR, Mass, COSY, HMQC, HMBC

etc.

. Strong understanding and hands-on experience of small molecule

analysis, structure elucidation and experience with techniques,

including MS, NMR, FTIR, chromatography and pKa analysis.

. Knowledge of Oral gavage, Euthanasia, Organ harvesting, extraction and

analysis of PK samples using LC-MS/MS.

Teaching Experience

Postdoctoral Research Mentor 2008

Graduate Research Mentor IICT - Hyderabad, India 2003

Teaching Assistant, Organic Chemistry BAPATLA ENGINNERING COLLEGE 1998

Teaching Associate, Intermediate Organic Chemistry SREESANJEEVANI COLLEGE

- Hyderabad, India 1996

Education

PhD, Organic Chemistry (Natural Product Chemistry)

IICT, KAKATIYA UNIVERSITY India

Master of Science, Organic Chemistry

NAGARJUNA UNIVERSITY India

Bachelor of Science, Chemistry and Biology

KAKATIYA UNIVERSITY India

Affiliations & RECOGNITIONS

Scientific Memberships - ACS, AAAS, AAPS, SigmaXi, Pac Mass

Scientific Reviewer - ChemComm, OBC, JCC, BMC, MRMC, AIAMC, MC

Scientific Awards - Most Enthusiastic Entrepreneur SEBA 2008, Senior

Research Fellow CSIR India 2002

Teaching and research interest

. Teaching General chemistry, Organic Chemistry and Laboratory

experiments (1-3 years of experience)

. Design and synthesis of novel anti-cancer agents and anti-infectious

(7 years of experience)

. Isolation and synthesis of biologically active small molecules from

Medicinal plants (5 years of experience)

Publications

1) Praveen Kumar Suryadevara, et al. Dialkylimidazole inhibitors of

Trypanosoma cruzi lanosterol 14 -demethylase against Chagas disease.

J. Med. Chem. Lett 2013 (Communicated).

2) Praveen Kumar Suryadevara, et. al. Novel C-9, 9?-O-acyl esters of -

Carinol as Free-radical Scavengers and Xanthine oxidase enzyme

inhibitors: Synthesis and Biological evaluation. Med. Chem. 2013 (9),

1, 100.

3) Buckner, F. S.; Bahia, M.; Praveen Suryadevara, et. al.

Pharmacological Characterization, Structural Studies, and In Vivo

Activity of Anti-Chagas Disease Lead Compounds Derived from

Tipifarnib. Anti-microbial Agents Chemotherapy 2012, 56 (9): 4914-21.

4) Praveen Kumar Suryadevara, et. al. Structurally simple Inhibitors of

Lanosterol 14?-Demethylase Are Efficacious In a Rodent Model of Acute

Chagas Disease. J. Med. Chem. 2009, 52, (12), 3703-3715.

5) Olepu,S Praveen Kumar Suryadevara, et. al. 2-Oxo-tetrahydro-1,8-

naphthyridine-Based Protein Farnesyltransferase Inhibitor as

Antimalarials. Bio. Med. Chem. Lett. 2008, 18, 494-498.

6) Bendale, P., Olepu, S., Praveen Kumar Suryadevara, et. al.Second

generation Tetrahydroquinoline Protein Farnesyltransferas Inhibitors

as Anti- Malarial. J. Med. Chem. 2007, 50, 19, 4585-4605.

7) Babu, K.S., Raju, B. C., Rao, A. S., Praveen Kumar, et. al.

Tungstophosphoric acid (H3PW12O40) an Efficient and Reusable

Heterogenous Catalyst for the Regioselective ring opening of Epoxides

with Amines. Syn. Comm. 2005, 35, 911-917.

8) Babu, K.S., Raju, B. C., Rao, A. S., Praveen Kumar, S. et. al. Bismuth

Triflate catalyzed One Pot Synthesis of Chromanoquinolines. J. Chem.

Res. (S) 2004, 421-423.

9) K.S., Raju, B. C., Srinivas, P. V., Rao, A. S., Praveen Kumar, S. et.

al. A Simple, Effective and Highly Selective Cleavage of 3-Methylbut-

2- enyl(prenyl) Ethers Using p-Toulenesulfonic Acid. Chem. Lett.

Babu, 2003, 32, 8, 704-705.

10) Praveen Kumar, S. et. al. A New and Convenient Method for

Quantitative Estimation of Chrysophanol, an Antioxidant in the

Rhizomes of Rheum emodi Roxb. Journal of Planar Chromatograph Modern

TLC. 2002, 15, 128-131.

11) Free Radical Scavenging Active Components from Cedrus deodara. Tiwari,

A. K., Srinivas, P. V., Praveen Kumar, S. et. al. J. Agric. Food

Chem. 2001, 49, 4042.

12) Rao, J. M., Babu, K. S., Tiwari, A. K., Babu, T. H., Srinivas, P. V.,

Suryadevara, P. K., Sastry, B. S., Ali, A. Z. and Yadav, J. S.

Intestinal alpha-glucosidase inhibitors and a process for the

isolation and use thereof.PCT Int. Appl. World Patent EP1986670, 05-

Nov-2008.

13) Rao, J. M., Babu, K. S., Tiwari, A. K., Babu, T. H., Srinivas, P. V.,

Suryadevara, P. K., Sastry, B. S., Ali, A. Z. and Yadav, J. S.

Intestinal alpha-glucosidase inhibitors and a process for the

isolation and use thereof. PCT Int. Appl. World Patent

(WO/2007/09639), 30-Aug-2007.

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