Professional Summary

> Experience in Object Oriented Programming, design, development and

implementation of scalable and robust software systems using Java and

J2EE.

> Substantial knowledge in Core Java.

> Sound knowledge in web oriented software development using Servlets, JSP,

JDBC, JNDI, JMS, Hibernate, Struts, Spring, EJBs, and Web Services.

> Familiar with XML and related technologies like AJAX, DOM/SAX parsers,

HTML, JSTL, CSS and JavaScript.

> Good experience in Object Relational Mapping tools, Hibernate.

> Knowledge in Web services using SOAP, WSDL and frameworks such ad Axis.

> Experience in using WebLogic and Websphere.

> Good Experience with Eclipse, MyEclipse and RAD

> Proficiency in the development of Web applications using MVC frameworks

including Apache Struts and Spring MVC.

> Used Log4j for logging and debugging purposes and JUnit for testing.

> Strong experience in Unix/Linux environment and shell scripting.

Software/Technical Skills

Operating Systems Windows, UNIX, Linux

Languages Java, C, C++, SQL

Web Technologies HTML, JSP, Servlets, Struts, JUnit, UNIX Shell

scripting, JavaScript, AJAX, XML, XSD, Webservices,

Hibernate, Spring MVC

J2EE Technologies EJB, RMI, JNDI, JDBC, JMS

IDE Eclipse, MyEclipse, RAD

Design Patterns J2EE Design Patterns: Business Delegate, Service

Locator, DAO, Session Fa ade, MVC, Front Controller

Application Tomcat, BEA Web Logic Server

Servers

Databases Oracle, SQL

Protocols TCP/IP, HTTP, HTTPS

Query Tools SQL

Testing Tools JUnit

Build Tools Ant, Maven

Education

1999 - 2003 : Doctor of Philosophy (Chemistry), Bharathidasan University,

India

1996 - 1998: Master of Science (Chemistry) St.Joseph's College,

Tiruchirappalli, India

1993 - 1996: Bachelor in Science (Chemistry) St.Joseph's College,

Tiruchirappalli, India

Certification:

> Oracle Certified Professional Java SE 6 Programmer (score 85%) .

Nationwide Insurance, Columbus, OH

Jun. 2013 - July. 2013

Application Development Center

Java J2EE Developer

Overview: Nationwide is one of the largest insurance and financial services

companies in the world. It provides insurance, retirement, investments,

and other products to consumers in the US. The Application Development

Center (ADC) develops an application for policy agents, users and policy

holders to handle day-to-day policy activities.

My project was Beginning of the Day (BOD) that allows the policy agents to

update and retrieve the day-to-day policy activity from portal. Major part

of my work was code-analysis and fixing the defects. We used hibernate to

access IBM-DB2 data base.

Responsibilities:

. Used Struts MVC based framework to develop the Application

Architecture.

. Implemented DAO for data access using Hibernate.

. Code analysis and fixing the defects.

. Designed and developed stored procedures.

. Used Junit for unit testing the application.

. Used JavaScript for client side validation.

. Used Log4J for logging.

. Used Subversion as source/version control.

. Used WebSphere application server and RAD as IDE for developing,

deploying and testing the application.

Environment:

Java, WebSphere, RAD, JSP, CSS, Struts, Web services, XML, HTML,

JavaScript, Hibernate, DB2.

Intern, Idhasoft Inc. Atlanta, GA

Sept. 2012 - Dec. 2013

During the internship, I obtained training on Employee Portal Management,

Manager Portal and Personal Banking System using Java/J2EE technologies.

Research (Non-IT) Experience

2009 - 2010 : Postdoctoral Researcher, Southern Research Institute, Drug

Discovery

Division, Birmingham, AL.

2006 - 2008 : Postdoctoral Research Fellow, Department of Chemistry,

University of

Louisville, Louisville, KY.

2004 - 2006 : Postdoctoral Research Fellow, Department of Biochemistry,

University

of Iowa, IA.

2002 - 2003 : Senior Research Fellow (Council of Scientific and

Industrial Research,

Government of India)

1999 - 2001 : Research Scholar, Bharathidasan University,

Tiruchirappalli, India.

Brief description of the current work at Southern Research Institute,

Birmingham

Structure and Function of Proline-rich Tyrosine Kinase (PYK2): Pyk2 is a

non-receptor tyrosine kinase (PTKs) implicated in integrin-dependent

tyrosine-phosphorylation and engage in focal adhesion where it colocalizes

with several other proteins to transduce information from cells to the

extracellular matrix and vice versa. Increased expression of PYK2 has been

observed in several human tumors and that presents this kinase a potential

molecular therapeutic target for cancer. Also it is considered a potential

drug target for osteoporosis treatment. Pyk2 composed of number of

functional domains including the NH2-terminal FERM domain, a central

catalytic kinase domain and a carboxyl-terminal focal adhesion targeting

(FAT) domain.

To date, the regulatory FERM domain of Pyk2 was the only functional domain

which lacked structural information, though the homology model of the FERM

domain of Pyk2 has recently been reported. In order to understand the

structural basis for the regulation of Pyk2, the data were collected to

3.2 from a crystal of Pyk2 Ferm domain and the manuscript is in

preparation. In pursuit of studying the full length Pyk2 structure,

recently we collected several data sets ranging from 1.7 - 2.0 from

crystals containing Ferm and kinase domains of Pyk2. Studying the structure

of this enzyme would reveal the functional role that Pyk2 plays in cellular

biology and facilitate in manipulating this drug target for therapeutic

purpose.

Summary of the work done at Department of Chemistry, University of

Louisville

Study on the structure and function of self-aminoacylating ribonucleic

acids (RNA) using x-ray crystallography: RNA can act as biocatalysts and

should, in principle, be able to catalyze most biological reactions

currently catalyzed by proteins. Our aim in studying the structure of RNA

was

. To unravel the functions of a catalytic RNA at the atomic level

. To understand how ribozymes (RNA) recognize substrates and perform

catalytic functions

. How can we modify these functions through structure-based RNA design

To address these, I had crystallized and optimized growth conditions in two

different crystal lattices of a particular RNA that has 66 nucleotides. The

crystallographic data has been collected both on a diffractometer (a

rotating anode x-ray source) as well as at the synchrotron facility

(Advanced Photon Source-Argonne National Lab., Chicago).

Summary of the work done at Department of Biochemistry, The University of

Iowa

Study on high resolution structures of Alcohol Dehydrogenases (ADH): ADH

plays an important physiological function in Mammals, where it facilitates

the reversible oxidation of alcohols into aldehydes and ketones with

Nicotinamide Adenine Dinucleotide (NAD) as the coenzyme. In yeast and

bacteria, ADH plays a similar role in fermentation, where it catalyzes

acetaldehyde into ethanol. These structural studies of ADHs are important

in developing therapeutic drugs for acute alcoholism and drug dependency in

patients.

Towards this effort I had worked on three different projects.

. Solved complex structures of Liver Alcohol Dehydrogenase with selected

lead compounds that would potentially treat poisoning by methanol and

ethylene glycol.

. Determined the structures of Liver ADH apo-enzyme and complexes with

ligands that bind to the catalytic zinc ion.

. Determined the Yeast (Saccharomyces cerevisiae) ADH, the enzyme of

choice for the production of ethanol from corn.

Summary of the Research work done at School of Chemistry, Bharathidasan

University

Crystallographic Studies of some complexes of Sulphoxine and Trimethoprim:

Sulphoxine and Trimethoprim are antiamoebic and antibacterial drugs

respectively.

. Studied the metal binding modes of sulphoxine.

. Studied trimethoprim-carboxylate interactions.

Obtained some remarkable structural motifs, in the form of H-bonded

chains, sheets and networks. These motifs are potentially important for

molecular recognition in the fields of crystal engineering/supramolecular

chemistry. Interestingly, some of the H-bonded interactions discovered in

my studies have actually been observed in protein-nucleic acid interactions

thereby proving that these interactions could be considered as a model for

drug-receptor recognition (the aminopyrimidine moiety of the drug forms H-

bonds with the carboxylate anion of the receptor molecule).

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