Doctoral Candidate (F/M/D)

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Doctoral candidate (f/m/d)

Operational area: Clinic for Gastroenterology, Metabolic Diseases and Internal Intensive Care Medicine (Med. Clinic III) -AG Professor Dr. Pavel Strnad/Dr. hum. biol. Nurdan Güldiken-

Working hours: Part-time 65% (currently 25,3 hours/week)

Duration/Term of employment: Initially limited to 3 years in accordance with the WissZeitVG. The successful candidate is expected to pursue a doctoral degree.

Start date: As soon as possible

Remuneration/Rates: EG 13 (TV-L)

Are you interested in uncovering the molecular mechanisms underlying epithelial integrity and organ injury in the esophagus and lung? Join our research team with strong expertise in cell and tissue biology, organ pathophysiology, and translational biomedical research.

Project: PhD Opportunities: Desmoplakin-Related Epithelial and Pulmonary Biology

Investigate the role of desmoplakin (DSP) in maintaining epithelial barrier function in the esophagus and lung tissue

Analyse how alterations in DSP expression, desmosomal structures, and cell–cell adhesion mechanisms contribute to diseases such as eosinophilic esophagitis, lung injury, or fibrosis

Study human tissue samples, cell culture models (epithelial cell lines and possibly 3D cultures)

Perform omics-based approaches (RNA-seq, proteomics), and functional assays (e.G., transepithelial resistance, cell migration, and adhesion studies).

The overall goal is to increase our understanding of DSP biology in the esophagus and lung and thereby to pave the way for new diagnostic or therapeutic strategies

Tasks:

Independent development and advancement of own research project

Active contribution to ongoing research initiatives

Support in the education and supervision of students

Preparation and publication of scientific manuscripts

Profile:

Master's degree in Life Sciences or related field

Background in biology, molecular biology, immunology, or related disciplines

Experience in basic and translational research

Experience with model organisms and bioinformatics tools is welcome

Ability to independently drive research projects

Proficiency in English, with xjliken strong communication and leadership skills (Level C1)

Why choose us?

We offer...

30 days of vacation

A bonus of 3,000 euros for employees who help recruit employees in the care sector

An attractive company pension scheme from VBL

Education opportunities, including updating and upgrading

Access to public transport

In-house kindergarten (places subject to availability)

Staff residences (places subject to availability and by arrangement)

An onboarding app for new employees

Extended opening hours in the staff restaurant