DMPK Project Leader to Early CVRM

Are you a strategic DMPK expert ready to lead cross-functional teams and shape project decisions? Join us in developing future treatments for Cardiovascular, Renal, and Metabolic diseases!

We are seeking a highly skilled and passionate DMPK Project Leader to join the DMPK & BBA (Drug Metabolism and Pharmacokinetics & Biomarker Bioanalysis) team within the early Cardiovascular, Renal, and Metabolism (CVRM) therapeutic area at AstraZeneca. Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. DMPK & BBA interacts with functions like Clinical Pharmacology, Safety, Bioscience, Translational Science and Clinical Development in supporting Early CVRM projects along the value chain, from target selection all the way to market launch and life-cycle management.

This position will be based at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden.

Accountability

As a DMPK Project Leader, you will hold a strategic and scientific role with high visibility. You will be responsible for the overall non-clinical DMPK contribution (including pre-clinical PK, translational PK and PK/PD, biotransformation and bioanalysis) across projects from lead optimization throughout Life Cycle Management to fulfil both internal and regulatory requirements. You will work with skilled DMPK scientists and teams to manage and deliver timely high-quality input to the projects you represent. Accountabilities include:

Define activities to understand the DMPK properties and meet internal/regulatory requirements consistent with project milestones and timelines

Apply state of the art DMPK science and regulatory strategies for at least 2 different types of drug modalities (i.e. small molecules, PROTACs, peptides, biologics, oligonucleotides)

Evaluate, interpret and integrate DMPK data to drive project deliverables - including review and transition through internal governance bodies

Project manage deliverables from internal/external sources and facilitate interpretation/integration into project knowledge

Work collaboratively with key colleagues in the project core team as well as the DMPK design leader, Biotransformation scientists, non-clinical modelers, safety sciences and Clinical Pharmacology scientists and act as the bridge for exchanging knowledge, data and progress

Prepare the DMPK part of regulatory documents (e.g. IND, IMPD, IB, NDA)

Represent DMPK in project meetings and communications with authorities as well as in Due Diligence and in-licensing activities

Initiate and drive scientific strategic initiatives on internal cross Therapy Area DMPK level, or on a cross Pharma level for either MIST, ADME studies & peptides, Oligonucleotide non-clinical DMPK/BT aspects, biologics, cell therapy, PKPD modelling or discovery perspectives influencing the Development phase

Publish scientific papers describing the non-clinical DMPK of their projects

Essential Skills/Experience

PhD or equivalent in relevant field, and at least three years of experience relevant to the position

Broad background and comprehensive understanding of discovery and development DMPK

Significant experience of leading and managing projects and teams to deliver scientific and functional knowledge from lead optimization/early development to life cycle management

Ability to operate across operational, tactical and strategic elements of the business

Broad experience in pharmaceutical R&D including compiling regulatory submissions

Track record of delivering DMPK contribution in development settings

Have experience of influencing the development program from a discovery perspective

Good understanding of chemistry, biology, pharmacology and clinical pharmacology as well as translational medicine

Highly developed interpersonal, communication (written and oral), organizational and relationship building skills

Flexibility and ability to thrive in a rapid paced environment

Capable of making difficult decisions in uncertain/evolving situations

Proven ability to deliver high-quality solutions on time, with adequate quality and within budget in a global environment

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

AstraZeneca offers an environment where curiosity thrives. We are committed to making a difference by fusing data and technology with scientific innovations. Our inclusive culture encourages collaboration across academia, biotechs, and industry to create impactful solutions for complex diseases. With opportunities for lifelong learning and career development, you can explore without limits while contributing to life-changing medicines.

Ready to make an impact? Apply now to join our team at AstraZeneca!

Welcome with your application no later than December 7th, 2025.

Date Posted24-nov.-2025

Closing Date07-dec.-2025

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

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