Research Senior Technician

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Job Title:

Research Senior Technician

Department:

CCC Sponsored Research

Research Senior Technician Job Description in Cancer Biology

School: Department of Internal Medicine, The Ohio State University.

Description: We are seeking a highly motivated and enthusiastic individual with a bachelor’s degree to join our group as research senior technician.

We are now accepting applications for a Research Senior Technician position in the laboratory of Dr. Triparna Sen at the Department of Internal Medicine, Division of Medical Oncology, at The Ohio State University.

Dr. Sen is a Professor in the Department of Internal Medicine, at The Ohio State University. The Sen lab aims to achieve a systematic and comprehensive understanding of the mechanisms of initiation, progression, and therapeutic resistance in lung cancer. The lab has established the use of multiple high-throughput screening technologies, genomics, proteomics, metabolomics, clinical samples, and animal models to accomplish these goals. The results will lead to the development of novel therapeutic strategies for the clinically relevant molecular subsets of lung cancer.

Position Summary:

The Researcher Senior Technician will be a core technical member of the lab, supporting all aspects of translational research with a focus on:

CRISPR screening platforms

Drug dosing studies in both in vitro and in vivo settings

Clinical sample processing, including the development of patient-derived xenograft (PDX) models

The successful candidate will work closely with postdoctoral fellows and other technical staff and play an integral role in executing experiments, maintaining research infrastructure, and supporting the broader goals of the lab.

Responsibilities:

Design and execute CRISPR-Cas9-based genetic screens in lung cancer cell models

Culture and manipulate human lung cancer cell lines and organoids, including transfections and viral transductions

Perform drug sensitivity assays in vitro and conduct dosing studies in mouse xenograft models

Establish and maintain PDX and CDX models using immunocompromised mouse strains (NSG, NRG, athymic nude)

Process human lung tissue specimens for downstream molecular and cellular analyses, including:

RNA/protein extraction

Flow cytometry and cell sorting

Single-cell suspensions for sequencing or culture

Operate lab equipment including GentleMACS Cell Dissociator, flow cytometers, biosafety cabinets, and centrifuges

Coordinate mouse studies: monitor health, measure tumor burden, maintain accurate animal records in compliance with IACUC protocols

Prepare experimental reagents, solutions, and maintain lab stocks

Organize and update biobank/sample databases and maintain meticulous experimental records in ELN or lab notebooks

Assist in procurement of lab reagents and equipment, coordinate with administrative staff for ordering and service contracts

Required Qualifications:

Bacheor’s Degree in Life Sciences or a related field.

Previous lab experience preferably (but not limited to) in cancer biology.

Proficiency in cell culture and standard molecular biology techniques.

Experience handling mice, including tumor implantation and drug administration is a requirement for this position.

Excellent interpersonal skills, problem-solving flexibility, and adaptability able to interface with lab staff.

Adept at planning and prioritizing work to meet commitments with a keen eye for detail.

Action-oriented and eager to take on new opportunities and tough challenges with a sense of urgency, high energy, and enthusiasm.

Function: Research and Scholarship

Sub Function: Research

Career Band: Individual Contributor - Technical

Career Level: T3

Additional Information:

Application Requirements: In addition to workday application requirements

Please send the following as a single PDF file via email to Dr. Subhamoy Chakraborty at ASAP:

Cover letter (maximum 2 pages) indicating research background, interest in the position, and expected start date

Curriculum Vitae (CV)

Reprints or PDFs of up to two relevant publications (if available)

Names and contact information of three professional references

Principal Investigator:

Dr. Triparna Sen

Professor, Department of Internal Medicine,

Associate Director of Research, Division of Medical Oncology

Director, Preclinical Therapeutics Platform,

The Ohio State University,

The Arthur G. James Comprehensive Cancer Center

508 Biomedical Research Tower

460 W 12Th Ave, Columbus, OH 43210

The Ohio State University is a dynamic community of diverse resources, where opportunity thrives and where individuals transform themselves and the world. The Ohio State University is one of the nation’s largest and most comprehensive public universities and a top employer in Ohio.

As one of only 57 designated comprehensive cancer centers in the nation, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis, and therapies – providing tomorrow’s standard of care today. A Cancer-Free World Begins Here.

The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities. is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities.

Location:

Biomedical Research Tower (0112)

Position Type:

Regular

Scheduled Hours:

40

Shift:First Shift

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

Thank you for your interest in positions at The Ohio State University and Wexner Medical Center. Once you have applied, the most updated information on the status of your application can be found by visiting the Candidate Home section of this site. Please view your submitted applications by logging in and reviewing your status. For answers to additional questions please review the frequently asked questions.

The university is an equal opportunity employer, including veterans and disability.

As required by Ohio Revised Code section 3345.0216, Ohio State will: educate students by means of free, open and rigorous intellectual inquiry to seek the truth; equip students with the opportunity to develop intellectual skills to reach their own, informed conclusions; not require, favor, disfavor or prohibit speech or lawful assembly; create a community dedicated to an ethic of civil and free inquiry, which respects the autonomy of each member, supports individual capacities for growth and tolerates differences in opinion; treat all faculty, staff and students as individuals, hold them to equal standards and provide equality of opportunity with regard to race, ethnicity, religion, sex, sexual orientation, gender identity or gender expression.

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