Director or Associate Director, Medicinal Chemistry

We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.

KEY RESPONSIBILITIES

Lead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates

Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles

Work closely with molecular and cellular biology, pharmacology, computational chemistry,

ADME, and other key functions

Act as liaison between Entos, CROs, and other external partners

Influence the prospective use of computational methods and leverage automated synthesis

and high-throughput experimentation capabilities

Work closely with AI/ML teams to develop and implement relevant predictive models to aid

in the design of new molecules

Communicate project updates clearly and effectively to the broader team and key

stakeholders

Work as a senior member of the Chemistry research group and foster a culture of scientific

excellence, innovation, and teamwork

PREFERRED QUALIFICATIONS

A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discovery

Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents

Ability to integrate multiple R&D disciplines into a successful strategic project plan

Experience in leading projects and driving programs through the preclinical development

process

Experience working with computational chemists as part of project team in design of drug targets is required

Strong interpersonal, communication, time management, and leadership skills

Experience mentoring or leading junior chemists

Creative problem solving and management of relationships with several stakeholders within

and beyond the company

Requirements

PREFERRED QUALIFICATIONS

A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discovery

Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents

Ability to integrate multiple R&D disciplines into a successful strategic project plan

Experience in leading projects and driving programs through the preclinical development

process

Experience working with computational chemists as part of project team in design of drug targets is required

Strong interpersonal, communication, time management, and leadership skills

Experience mentoring or leading junior chemists

Creative problem solving and management of relationships with several stakeholders within

and beyond the company

Benefits

Dental, Medical, Vision and 401K