Postdoctoral Researcher, Arce Lab

Overview

The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

Funding: Arc fully funds Core Investigators (PIs) research groups, liberating scientists from the typical constraints of project-based external grants.

Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.

Support: Arc aims to provide first-class supportoperationally, financially, and scientificallythat will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.

Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc has scaled to nearly 200 people. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.

About the position

The Arce Lab investigates the regulatory mechanisms that are required for distinct immune functions in an effort to identify and correct the origins of immune-mediated disease. We are seeking a highly motivated, enthusiastic postdoctoral researcher to join our team at Arc. In this role, you will adapt and integrate cutting edge gene editing techniques and genomic assays to investigate the genetic origins of autoimmune diseases. With consideration for the multi-factorial nature of complex disease, you will design and execute experiments aimed at understanding how dysfunction occurs at a cellular level. From the non-coding genome, to the multimeric proteome, there are opportunities to identify novel mechanisms controlling important immune functions that can be leveraged for therapeutic benefit. Within this role you will have the opportunity to investigate how each of these components contributes to immune homeostasis. You will be expected to make decisions regarding the direction of the project(s) that you lead and work independently on a daily basis.

About you

You are deeply curious about the mechanisms that control immune cell function

You are a creative problem solver and are resilient in finding solutions

You are enthusiastic about the opportunity to develop and refine projects and processes

You are passionate about understanding how biological systems work and excited to make discoveries that may improve human health

You are self-motivated and work efficiently with diligence

You prioritize a positive work environment for yourself and your teammates

In this position you will

Investigate the role of autoimmune risk variants on cellular functions

Apply CRISPR genome editing in primary human immune cells

Generate and analyze single cell multi-omics data

Collaborate both internally and with external institutions to pursue the biochemical mechanism of specific regulatory factors

Communicate your work in the form of publications and presentations

Participate in lab meetings and Institute-wide activities (seminars, symposiums, etc).

Requirements

PhD in immunology, genomics, genetics, biological sciences or related fields

Highly collaborative team player willing to both learn from and train others

Ability to work independently to establish new technical protocols and derive biological insight from findings

Resourceful and eager to push forward progress

Excellent written and verbal communication skills

Preferred Qualifications

Experience with CRISPR gene editing and high throughput screening

Proficiency in coding languages such as R or Python for genomic data analysis

Experience with immune cell culturing and immunological functional assays

The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.

Apply for this job

* indicates a required field

First Name *

Last Name *

Email *

Phone

Country *

Phone *

Resume/CV *

Enter manually

Accepted file types: pdf, doc, docx, txt, rtf

Enter manually

Accepted file types: pdf, doc, docx, txt, rtf

LinkedIn Profile

Website

Are you currently authorized to work in the US? *

Will you now, or in the future, require employer visa sponsorship (e.g., H-1B)? *

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Arc Institutes Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305

OMB Control Number 1250-0005; Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. If you want to learn more about the law or this form, visit the U.S. Department of Labors Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your major life activities. If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

Alcohol or other substance use disorder (not currently using drugs illegally)

Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS

Blind or low vision

Cancer (past or present)

Cardiovascular or heart disease

Celiac disease

Cerebral palsy

Deaf or serious difficulty hearing

Diabetes

Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders

Epilepsy or other seizure disorder

Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome

Intellectual or developmental disability

Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD

Missing limbs or partially missing limbs

Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports

Nervous system condition, for example, migraine headaches, Parkinsons disease, multiple sclerosis (MS)

Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities

Partial or complete paralysis (any cause)

Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema

Short stature (dwarfism)

Traumatic brain injury

Disability Status

Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete. #J-18808-Ljbffr