SRA / Scientist, Biotherapeutics Mass Spectrometry

Who We Are

EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, is on schedule to enter clinical trials in 2025. Additional collaboration pipeline programs and wholly owned programs are progressing toward candidate nomination. EvolveImmune's team consists of over 45 FTEs in R&D, business development and operations with immediate plans for additional growth. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston/New York City corridor.

We value curiosity, collaboration, and diverse perspectives-if you're excited by our mission but unsure if you meet every requirement, we encourage you to apply.

What You'll Work On

• Design and execute LC-MS-based workflows to characterize antibody and protein-based therapeutics, including intact and subunit mass analysis, peptide mapping, glycan profiling, and post-translational modifications.

• Perform biochemical and biophysical analyses to evaluate structural integrity, stability, and binding properties using SEC, HIC, DSC, ELISA, SPR, and BLI.

• Interpret data, identify molecular trends, and generate actionable insights to guide therapeutic candidate selection and optimization.

• Collaborate cross-functionally with colleagues in protein engineering, immunobiology, and translational science to support pipeline advancement.

• Present findings in internal meetings and contribute to publications and patent filings.

• Stay current with innovations in analytical and biophysical characterization of biologics.

What You Bring

• PhD in Protein Biochemistry, Biophysics, Analytical Chemistry, or a related field with 2+ years of postdoctoral or industry experience; or MS with 5+ years, or BS with 8+ years of relevant experience in biotech/pharma in biotherapeutic characterization by mass spectrometry.

• Hands-on expertise with protein and peptide liquid chromatography and mass spectrometry instrumentation, protein and peptide mass spectrometry sample preparation, and mass spectrometry biotherapeutic characterization of intact, reduced mass, and peptide mapping of posttranslational modifications.

• Strong analytical mindset and ability to troubleshoot instrumentation and experimental workflows.

• Excellent communication skills and ability to contribute in a team-based setting.

Preferred Qualifications

• Experience in biotherapeutic sample preparation includes protein deglycosylation, reduction, and in-solution digestion of proteins.

• Experience with Waters Xevo line of mass spectrometers and familiarity with UNIFI software

• Experience with peptide mapping post-translational modifications and release-glycan assessment

• Understanding of antibody structure-function relationships and T cell engager formats.

What You'll Gain

• A critical role on the Biotherapeutics team developing novel biologics and platform innovations.

• Opportunity to expand your skills in protein science, immuno-oncology, and cross-functional drug discovery.

• Access to cutting-edge instrumentation in a purpose-built lab space.

• Mentorship from experienced scientific leaders and collaboration with passionate scientists across disciplines.

• The chance to advance a pipeline of first-in-class cancer immunotherapies.

Why You'll Love Working Here

• Direct impact: Your work will inform candidate selection and shape next-gen platform designs.

• Cutting-edge science: Join a team at the forefront of T cell engager and immunotherapy innovation.

• Personal growth: Gain broad exposure to discovery-stage drug development in a high-growth company.

• Collaborative culture: Work in a supportive, cross-functional environment where your ideas matter.

• Top-tier facilities: Enjoy our modern, collaborative lab space in Branford, CT.

Additional Info

• This is a full-time, onsite position based in Branford, CT.

• EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered.

• We offer a competitive salary, benefits, equity, and paid time off.

• EvolveImmune is an equal opportunity employer committed to fostering a diverse and inclusive workplace. • Learn more about our science and team at

Search Keywords:

Senior Research Associate Scientist Biotherapeutics Mass Spec Protein Chemistry Antibody Characterization T Cell Engagers Biotech Branford CT LC-MS Jobs Immuno-Oncology Careers Biologics Discovery Protein Engineering Biophysical Analysis Oncology Therapeutics Biotech Research Jobs CT EvolveImmune Careers