Large Molecule Principal Scientist

Job Description

Salary:

JOB SUMMARY

We are seeking a highly experienced and innovative Principal Scientist to lead the design, execution, and development of small molecules, large molecules, biologics, and mRNA-based projects. This role requires a deep understanding of complex biologics including monoclonal antibodies, proteins, mRNA vaccines/therapeutics, and other next-generation modalities. The ideal candidate will have a proven track record in leading scientific teams, supervising and training junior scientists, and managing cross-functional projects in a fast-paced GMP regulated environment.

The Principal Scientist will apply a diverse portfolio of analytical, molecular, and cell-based techniques to support method development, optimization and validation. Responsibilities include setting technical strategies, overseeing experimental execution, interpreting complex data, and driving innovation across diverse programs. This position requires strong leadership, communication, and collaborative skills to work effectively with internal and external stakeholders.

PRIMARY DUTIES AND RESPONSIBILITIES

Lead the development, optimization, and execution of analytical and bioanalytical methods for biologics and mRNA-based therapeutics. Additional experience in small molecules is a plus.

Design and supervise experimental studies supporting product characterization, assay development and Validation.

Train and mentor scientists and foster a culture of scientific rigor and continuous learning.

Drive troubleshooting, data interpretation, and technical problem-solving across multiple platforms.

Collaborate with cross-functional teams (e.g., QC, QA, RM etc.) to advance project goals.

Manage timelines, resources, and scientific strategy for multiple concurrent projects.

Assists division director as necessary providing updates on projects, system and personnel capacity as well as visibility into project timelines.

Ensure all appropriate work is performed in compliance with standard operating procedures, good manufacturing practices, and the regulations of the Food and Drug Administration and United States Pharmacopeia or other compendial methodologies.

Reverse Phase (RP-HPLC), Ion Exchange (IEX), Size-Exclusion Chromatography (SEC), Hydrophobic Interaction Chromatography (HIC)

Purity, charge variants, aggregation, and fragmentation analysis

Intact mass analysis, peptide mapping, glycan profiling, and post-translational modification (PTM) analysis using LC-MS/MS and QTOF/Orbitrap platforms

Capillary Gel Electrophoresis (CGE), Isoelectric Focusing (IEF), SDS-PAGE, Western blotting, ELISA, and cell-based functional assays

DLS, LC/MS, encapsulation efficiency via RiboGreen, Cell culture, Potency assays

REQUIREMENTS & QUALIFICATIONS

Qualifications include a PhD, Masters or Bachelors degree in Biochemistry or a related discipline. Must have laboratory experience with a minimum of 3+ years of experience related to large molecules/ mRNA with a PhD, or 6+ years of experience related to protein drug development combined with a Masters degree, or a minimum of 8+ years of related to protein drug development work experience combined with a Bachelors degree and 0-2 years in a leadership role.

MINIMUM SKILLS REQUIREMENTS

Must have the ability and skill to perform the detailed job requirements noted above competently, safely and proficiently.

Must have excellent organizational, verbal communication and technical documentation skills.

Solid writing ability and computer skills.

Knowledge of safe laboratory practices, including the proper procedures in handling chemicals and samples.

Must be a team player with integrity and concern for the quality of Company products, services and staff members. Ability to be an effective hands-on leader.

Full-time