Senior Associate Scientist II-Protein Scientist

Job Description

Job Title:

Senior Associate Scientist II - Protein Scientist

Reports to (title):

Xiaofei E, Senior Principal Scientist, Molecular Therapeutics

Solid Summary:

Solid Biosciences is a life science company focused on advancing a portfolio of neuromuscular and cardiac programs, including SGT-003, a differentiated gene therapy candidate for the treatment of Duchenne, SGT212, a gene therapy program for the treatment of Friedreich’s Ataxia, SGT-501, a gene therapy program for the treatment of catecholaminergic polymorphic ventricular tachycardia, SGT-401 a gene therapy program for the treatment of BAG3 mediated dilated cardiomyopathy, and additional assets for the treatment of fatal cardiac diseases. Solid aims to be the center of excellence across a given disease spectrum bringing together those with expertise in science, technology, disease management, and care. Patient-focused and founded by those directly impacted, Solid’s mandate is to improve the daily lives of patients living with these devastating diseases.

Position Summary:

We are seeking a skilled and motivated associate scientist to join the Molecular Therapeutics team to purify AAV libraries and to define the mechanism of transduction of selected capsids. The ideal candidate will have a strong background in protein science including protein binding assays, protein structure, and cell biology.

Key Duties & Accountabilities:

Optimize methods for production and isolation of AAV capsid libraries using automated liquid handlers such as Tecan

In vitro AAV transduction experiments in normal and CRISPr KO cells

Protein binding and inhibition experiments

Contribute to modelling of protein structures

Collaborate within the molecular therapeutics team and across the R&D organization including computational biologists, analytical development, and process development

Communicate findings and insights to stakeholders through reports, presentations, and visualizations.

Core Competencies Required:

Experience with AAV and/or antibody production and drug development

Strong technical skills in protein biochemistry and cell biology to define the mechanism of AAV transduction

Proficiency in computing include Geneious, BLAST, Ensembl, NCBI, Uniprot, USCS, GTEx, Microsoft, PRISM statistics program

Candidates with experience in molecular modeling such as alpha-fold, DynamicBind, or equivalent will be preferred

Strong problem-solving skills and the ability to work independently and collaboratively.

Excellent communication and presentation skills.

Knowledge: Education, Experience, & Skills:

Bachelor of Science with either a Master’s degree and/or 3 years’ industry experience in protein science research

Travel Commitment:

Solid Biosciences, Charlestown, MA

Role Location

(HQ, Hybrid, Remote, NC, etc.)

HQ

Full-time

Hybrid remote