Scientist I, Process Development

Description

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and Huntington’s disease, and obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description:

Wave Life Sciences seeks a highly motivated Scientist I to join its Process Development team in Lexington, Massachusetts. This is an ideal position for an individual with a strong background in oligonucleotide upstream as well as downstream workflow and analytical characterization. Excellent opportunity for a candidate who thrives in a team-oriented, fast-paced, and cross-disciplinary biotech environment. The candidate will be part of a group focused on Process Development and process optimization aspect of synthesis and purification of oligonucleotides. This candidate will contribute to all levels of research to support the development of optimized nucleic acid therapies in multiple disease areas. Prior experience in industry in oligonucleotide synthesis is desired but not required.

Experience:

Requires a master’s degree in chemistry, biochemistry or related discipline with 4-7 years of related experience or a bachelor’s degree in chemistry, biochemistry or related discipline with 13-15 years of related experience

Responsibilities:

Synthesis of oligonucleotides, deprotection, purification, ultrafiltration and lyophilization of oligonucleotides to support projects in multiple disease areas.

Optimization of downstream processing methods and scaling up is required. Broad knowledge and experience of IEX and Reverse-phase chromatographic technique is required.

Supports continuous improvement initiatives and helps in implementing strategies once approved. Supporting various teams in impurity characterization and analysis. Ability to analyze and interpret data independently using HPLC and LC-MS.

Plan, organize and carry out laboratory work to improve the existing processes and develop new processes as well. Able to take directions from senior management and execute in timely manner.

Conduct laboratory work in a safe, efficient manner that ensures a safe working environment for all lab members.

Familiarity with pre-clinical drug development and IND-enabling phase of therapeutic programs is desired but not required.

Capacity to be highly productive in a fluid and fast-paced work environment.

Present results clearly in both written and oral format.

Keep accurate documentation of the experiments and summarize the results of the projects in written reports

Key Skills:

Strong knowledge of nucleic acids chemistry, oligonucleotide synthesis, deprotection and purification techniques

Experience with the ÄKTA line of synthesizers is desired and ÄKTA line of purifiers required

Familiarity with analytical techniques and data interpretation HPLC, LC-MS is required

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.