R&D Scientist - Nucleotide Chemistry

Sarmal, an innovative biotech company based in San Diego, California, is seeking a highly skilled R&D Scientist specializing in Nucleotide Chemistry to join our cutting-edge research team. We are developing revolutionary genomics platforms that aim to transform the fields of genetic testing and sequencing.

Key Responsibilities:

Design and synthesize novel nucleotide analogs for our proprietary FLASH sequencing technology

Develop and optimize nucleic acid modification strategies for both TEEM and FLASH platforms

Lead research projects focused on improving nucleotide chemistry for enhanced sequencing and detection capabilities

Collaborate with cross-functional teams to advance project goals

Contribute to the development of intellectual property and patent applications

Required Qualifications:

Ph.D. in Organic Chemistry, Biochemistry, or a closely related field with a focus on nucleotide chemistry

5+ years of post-doctoral experience in nucleotide chemistry research

Extensive hands-on experience with nucleic acid modifications, including base, sugar, and phosphate modifications and functionalizations

Strong understanding of sequencing technologies, PCR, and enzymatic interactions

Proven expertise in synthetic and organic chemistry, particularly related to nucleotide analogs

In-depth knowledge of polymerase-substrate activity and interactions

Demonstrated ability to design, execute, and analyze complex chemical synthesis experiments

Excellent problem-solving skills and attention to detail

Strong written and verbal communication skills

Preferred Qualifications:

Industry experience in biotechnology or pharmaceutical sectors

Familiarity with next-generation sequencing technologies and their chemical foundations

Experience with luminescent or fluorescent nucleotide modifications

Track record of publications in peer-reviewed journals and/or patents in nucleotide chemistry

Experience in project management and team leadership

We Offer:

Competitive salary commensurate with experience

Opportunity to work on groundbreaking nucleotide chemistry projects

State-of-the-art laboratory facilities in La Jolla, CA

Collaborative and innovative work environment

Professional development and growth opportunities

Join our team and contribute to the development of disruptive technologies that aim to revolutionize genetic testing and sequencing.

Sarmal is an equal opportunity employer and values diversity in our workforce.

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