Senior/Staff Engineer, Application

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you:

Glyphic is seeking an experienced applications engineer to translate our cutting-edge single molecule proteome sequencing protocols to automated instrumentation. The ideal candidate will have extensive experience developing complex assays on the Hamilton Star liquid handling platform for DNA & protein biochemistry and/or NGS applications. The engineer will work with a cross-disciplinary team of chemists, biologists, engineers, and bio-informaticians to deploy robust production processes across a range of laboratory automation and custom microfluidic instruments.

Responsibilities:

Design, develop, deploy, and rapidly improve automated protein sequencing solutions in a fast-paced startup environment.

Evaluate new instrumentation fit for purpose and integrate new automated capabilities into existing platform

Partner with R&D to translate existing benchtop protocols and new protocol concepts across multiple platforms to demonstrate feasibility

Define standardized liquid handler programming schema for rapid protocol, labware, and liquid class reusability

Utilize scheduling software to integrate multiple instruments and optimize automated protocols for throughput

Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development.

Maintain expertise on alternate methods, techniques and best practices used in the field; routinely benchmark process performance

Thoroughly document the development lifecycle:

User requirements and instrument selection

IQ/OQ/PQ

Operator SOPs and training materials

Instrument docs and maintenance procedures Required Competencies:

Degree in bioengineering, biology, chemistry, or related field, PhD preferred

6+ years hands-on industry experience with liquid handlers and lab automation

Extensive experience developing assays on Hamilton Microlab Star / Venus

Experience troubleshooting complex instrument/assay issues, performing root cause analysis, and driving corrective actions in a production environment

Experience quantifying and qualifying your work through IQ/OQ/PQ

Experience with laboratory information management systems

Advanced programming and data modeling/analysis skills (Python, C++, vendor platforms) Preferred:

Experience with protein-based assays, nucleic acids biochemistry, and bioconjugation

Experience developing and deploying methods in a regulated environment (GxP/CLIA/CAP/ISO)

Experience with instrument integrations and scheduling software

Experience developing of a commercial product Benefits and Perks:

Employee Stock Option Plan

100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)

Employer Retirement Contributions to 401(k)

Generous Paid Time Off

Paid Maternity and Paternity Leave

Health & Wellbeing Program

Office Snacks and Beverages

Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.