Research Scientist, Biochemistry

Job Summary

We are seeking a biochemist to join the Biochemistry group within Protein Science and Technology Department. In this role, the scientist will contribute to our early drug discovery efforts by supporting design, development, and execution of a variety of biochemical and biophysical assays. They will collaborate closely with cross-functional teams to advance projects from hit identification and qualification through lead optimization. The ideal candidate will be scientifically curious, team-oriented, and driven by a growth mindset.

Summary of the Essential Functions of the Job

Assay development and execution

Support the design, development and execution of biochemical and biophysical assays (e.g., enzyme activity assays, and biophysical assays, including SPR, ITC, DSF) to drive small molecule hit identification, and lead optimization.

Data collection and analysis

Collect, organize and record biochemical and biophysical assay data, opportunities for data analysis and presentation.

Protein purification and characterization

Apply various protein purification techniques (e.g., affinity, ion-exchange, size-exclusion chromatography) to obtain high-quality proteins for assay and structural biology need.

Lab equipment proficiency

Operate various laboratory instruments and automation tools, including multichannel pipettes, multi-well plate liquid dispensers, multimode plate readers, and other biophysical instruments.

Minimum Requirements

Master’s, or Ph.D. in Biochemistry, Biophysics, Chemical Biology, Protein Science, or a related life science field, 1+ year industry experience is preferred

Fundamental understanding of enzymology and biophysics (e.g., enzyme kinetics, enzyme inhibition and activation; and kinetics and thermodynamics of protein ligand interactions

Experiment efficiency with wet lab work, such as preparation, characterization and caretaking of buffers, reagents, and consumables.

Hands-on experience with protein purification and characterization, biochemical and biophysical assays with various throughputs and technologies.

Experience with data analysis and curve-fitting software (e.g., Prism, Genedata).

Effective oral and written communication skills, including presenting data and project updates.