Senior Cheminformatics Analyst- Chemical Biology and Therapeutics

Join Our Team!

The Department of Chemical Biology and Therapeutics is seeking a Senior Cheminformatics Analyst to join our innovative and multidisciplinary team. In this role, you will leverage your expertise in cheminformatics, systems biology, and drug-gene interactions, and network analysis to drive forward cutting-edge drug discovery projects. You’ll work closely with researchers in the Center of Excellence for Data-Driven Discovery, applying advanced computational techniques to develop novel therapeutics.

This position will work closely with researchers in the Center of Excellence for Data Driven Discovery. The Ideal candidate will work on Projects that will focus on advancing cutting-edge drug discovery programs for childhood catastrophic diseases using the latest approaches in proximity-based targeting. Specifically, based on the mechanistic basis of disease, our goal is to develop unique chemical approaches (protein degraders, synthetic gene regulators and/or functional effectors) to degrade or manipulate targets relevant to pediatric oncology, neurodegenerative disorders and sickle cell disease.

The Department of Chemical Biology and Therapeutics is a leader in pioneering research for childhood catastrophic diseases. We are dedicated to advancing drug discovery using the latest in proximity-based targeting and data-driven science. Join our collaborative team, where your expertise will directly impact the future of pediatric oncology, neurodegenerative disorders, and sickle cell disease.

Job Responsibilities:

Analyze biomedical data with minimal supervision by performing advanced analysis, algorithm implementation, programming, and quality check.

Assist senior analysts and scientists in the courses and training - with in-house training programs, user groups, seminars, documentation, and newsletters.

Evaluate and integrate products, solutions, tools, and web-based applications.

Assist in the development, implementation, and maintenance of relevant databases or data warehouse.

Develop prototypes for cloud portals and visualization tools; programs for the analysis of data within databases.

Develop web services to query the database.

Communicate with project managers on design and implementation of analytical processes, project progress, and results.

Minimum Education and/or Training:

Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.

Master's degree or PhD preferred.

Industry experience preferred

Minimum Experience:

Minimum Requirement: 4+ years of relevant experience required.

Experience Exception: Master's degree and 1+ years of relevant experience.

Experience in at least one programming or scripting language and at least one statistical package, with R preferred.

Preferred Technical Expertise:

Proficient in structure-based drug design (SBDD), including small molecule docking, pharmacophore modeling, virtual screening, and molecular dynamics.

Skilled in ligand-based modeling (QSAR, conformational analysis) and protein modeling (homology modeling, ab initio prediction, protein-protein docking).

Experience with cheminformatics techniques: chemical reaction/library enumeration, similarity analysis, clustering, and dimensionality reduction.

Application of machine learning in drug discovery: target identification, drug repurposing, virtual screening, PK/PD modeling, and drug-drug interaction prediction.

Data mining, statistical algorithm design, and biostatistical analysis.

Ideal Candidate

Team Player: Thrives in a collaborative, multidisciplinary environment and enjoys working closely with colleagues from diverse backgrounds.

Multitasker: Demonstrates the ability to manage multiple projects and priorities simultaneously without compromising quality or deadlines.

Flexible: Adapts quickly to shifting project needs, new technologies, and evolving scientific challenges.

Proactive Communicator: Shares ideas openly, seeks feedback, and keeps stakeholders informed.

Creative Problem Solver: Approaches challenges with curiosity, innovation, and a solutions-oriented mindset.

CompensationIn recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $78,000 - $139,360 per year for the role of Senior Cheminformatics Analyst- Chemical Biology and Therapeutics.

Explore our exceptional benefits!

St. Jude is an Equal Opportunity Employer

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