SRA/Assoc Scientist/Scientist, Biotherapeutics

Job Description

Who We Are

EvolveImmune Therapeutics is a next-generation immunotherapy company pioneering a new class of precision cancer medicines to transform patient outcomes, compared to current solid tumor therapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell co-stimulation to directly target tumor cells to deliver durable, tissue-localized anti-tumor adaptive immune responses. Our newly expanded, state-of-the-art 16,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor and our laboratory footprint in Farmington, CT support in-house biologics, immunobiology, and translational activities, enabling our rapid pipeline progress. This includes EV-104, our lead solid tumor program rapidly advancing toward IND filing.

The Role

We are seeking a highly motivated and skilled Scientist to join our dynamic Biotherapeutics team and contribute to the characterization and development of our next-generation immuno-oncology pipeline. This role will focus on utilizing LC-MS, biochemical and biophysical methods to analyze and characterize the structural integrity, functionality, and stability of these innovative molecules.

Key Responsibilities

Develop and execute LC-MS workflows for biotherapeutics characterization, including intact and subunit mass analysis, peptide mapping, glycan profiling, and post-translational modification analysis.

Perform analytical, biochemical, and biophysical assays using techniques such as SEC, HIC, DSC, ELISA, SPR, and BLI to assess purity, stability, aggregation propensity, and target binding kinetics and affinity.

Collaborate effectively with cross-functional teams to ensure alignment of project goals and deliver accurate and timely results.

Analyze and interpret experimental data to draw meaningful conclusions, present findings and recommendations to team and management.

Address and resolve technical challenges related to LC-MS instrumentation and data analysis.

Stay current with advancement in LC-MS and biophysical techniques, implementing innovative approaches where applicable, contribute to scientific publications.

Qualifications

PhD in Protein Biochemistry and Biophysics, or a related field with 2+ years of relevant experience; or MS with 5+ years, or BS with 8+ years of experience in industry settings.

Strong expertise in LC-MS techniques for protein analysis, including hands-on experience with instruments and data analysis.

Proficiency in biophysical methods for protein characterization, particularly in analyzing antibody stability and target interactions.

Strong analytical and problem-solving skills with attention to detail.

Effective communication skills for presenting complex data to diverse teams.

Ability to work collaboratively in a cross-disciplinary environment.

Preferred Qualifications

Experience with protein expression in mammalian systems and purification techniques.

Familiarity with the structure and function of T cell engagers and their unique analytical challenges.

Experience in immune cell biology and functional cell-based assays relevant to T cell engagers.

EvolveImmune Therapeutics requires all employees to be fully vaccinated against COVID-19. You may seek reasonable accommodations for medical and religious reasons. However, your application is no guarantee that such accommodations will be made available.

EvolveImmune provides a competitive compensation and benefits package.

EvolveImmune Therapeutics, Inc. is an equal opportunity employer.

Full-time