Postdoctoral Fellow in Bioinformatics

Position Summary

Neuroimaging Genomics Lab Center for Neuroimaging Indiana University School of Medicine, Indianapolis, IN, USA Description The Neuroimaging Genomics Laboratory, co-led by Drs. Kwangsik Nho and Andrew Saykin of the Indiana University School of Medicine Center for Neuroimaging (CfN), has immediate full-time openings for one or more outstanding, highly motivated post-doctoral research fellows with special interest in human genomics/computational systems biology to work on multi-omics analyses of Alzheimer’s disease and related disorders ( ADRD ). The Lab’s overarching goals are 1) to achieve a better understanding of the complex causes and mechanisms leading to ADRD, 2) to improve early detection and longitudinal monitoring by combining genomics, fluid biomarkers and advanced neuroimaging and 3) to identify novel targets for diagnostic applications and therapeutic intervention. Fellows will work on research problems leveraging multiple rich data sets and leading-edge analytic approaches supported by multiple NIH grants (R, U and P programs). Topics include (a) human genetics of ADRD using quantitative endophenotypes from neuroimaging and fluid biomarkers, (b) systems biology analysis of pathways from multi-omics data using multi-layered network approaches, © machine learning for identification of genetic risk factors in ADRD, (d) relation of central and peripheral omics to ADRD biomarkers and clinical measures, and (e) studies in diverse multiethnic populations to broaden our understanding of genetics and ADRD biomarkers. Fellows will take the lead in preparing manuscripts for publication and contribute to grant applications while collaborating on other projects as part of a multidisciplinary team science effort. Special opportunities afforded by this fellowship include experience working with the Genetics Core of the Alzheimer’s Disease Neuroimaging Initiative ( ADNI ), Indiana Alzheimer’s Disease Research Center ( IADRC ), Center for Computational Biology and Bioinformatics ( CCBB ), and multiple NIH sponsored multicenter programs including the Alzheimer’s Disease Genetics Consortium ( ADGC ), Alzheimer’s Disease Sequencing Project ( ADSP ), Centrally-linked longitudinal peripheral biomarkers of AD in multi-ethnic populations ( CLEAR -AD.org), Artificial Intelligence for Alzheimer’s Disease (AI4AD.org), Alzheimer’s Disease Metabolomics Consortium ( ADMC ), Accelerating Medicines Partnership Program for Alzheimer’s disease ( AMP -AD), and Model Organism Development & Evaluation for Late-Onset Alzheimer’s disease ( MODEL -AD). Requirements Successful applicants will have strong academic preparation (PhD, MD, MD/PhD or equivalent, in a relevant discipline), high motivation and enthusiasm for research, excellent written and oral communication skills including evidence of successful manuscript writing and publication productivity, strong intellectual curiosity, creativity, flexibility, a commitment to the scientific goals of the program, desire to make a contribution, and the ability to work independently and as part of a collaborative transdisciplinary team, which includes mentoring graduate and undergraduate students. Preference will be given to candidates with experience in one or more of the following areas: human genetics, computational neuroscience, multi-omics data analysis including RNA -Seq, and systems biology/network analysis. Strong data science skills are required. Applicants who have recently completed their terminal degree and plan to develop an independent research career are especially encouraged to apply, as are candidates from groups underrepresented in biomedical research. Application Instructions Review of applicants will continue until the positions are filled. Please email a cover letter with a brief description of research experience, interests and goals, full CV, and contact information for three references to Dr. Kwangsik Nho ( ). Indiana University Indiana University is a multi-campus public research institution and a world leader in professional, medical, and technological education with an annual operating budget of $2.1 billion. The Indiana University School of Medicine ( IUSM ) is annually ranked among the top medical schools in the nation by U.S. News & World Report. IU School of Medicine is the largest medical school in the United States and offers high-quality medical education, access to leading medical research and rich campus life in nine different Indiana cities, including rural and urban locations consistently recognized for livability. IUSM is committed to being a welcoming campus community and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for all students, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana. The IUSM researchers received over $243 million in total funding from the NIH during federal fiscal year 2023. IUSM’s 2023 NIH funding ranked No. 13 among public universities. Additionally, IUSM provides an interdisciplinary, collaborative, and interactive scientific environment with many multidisciplinary centers and state-of-the-art core facilities. IUSM’s clinical partner, IU Health, operates an organized system of care across 18 hospitals that offers unmatched potential for clinical, educational, and research collaborations.