Associate Scientist / Scientist

Company Overview:

SystImmune Inc. is a dynamic clinical-stage bio-pharmaceutical company headquartered in Redmond, WA. Our mission is to revolutionize cancer treatment by developing breakthrough-therapeutic multi-specific antibodies and ADCs. With eight assets in ongoing clinical trials and a robust preclinical pipeline, we are committed to advancing innovative therapies from discovery through IND-enabling stages.

Job Summary:

We are seeking a Scientist with over 10 years of experience in mass spectrometry-based bioanalysis to lead our team focused on pharmacokinetic (PK) testing of Antibody-Drug Conjugate (ADC) free payloads. In this hands-on role, you will be responsible for developing and implementing cutting-edge mass spectrometry assays to quantitatively analyze ADC free payloads in biological samples. The ideal candidate will have extensive expertise in analytical chemistry, method development, and bioanalytical techniques, along with a professional background in oncology drug development.

Essential Duties and Responsibilities:

Lead the development and validation of mass spectrometry-based assays for the quantitative analysis of ADC free payloads in biological matrices.

Design and optimize sample preparation methods to extract and purify ADC free payloads from complex biological samples, ensuring robustness and reproducibility.

Conduct comprehensive analytical method validation studies, including method qualification and validation parameters such as accuracy, precision, selectivity, and stability.

Oversee PK studies to analyze ADC free payload concentrations in preclinical and clinical samples, providing critical pharmacokinetic data to support drug development programs.

Collaborate closely with cross-functional teams to design and execute preclinical and clinical PK studies, contributing expertise in mass spectrometry-based bioanalysis.

Stay abreast of advancements in mass spectrometry instrumentation, software, and methodologies, implementing innovative techniques to enhance assay sensitivity and efficiency.

Troubleshoot technical issues and implement solutions to optimize assay performance, ensuring data quality and integrity throughout the analytical process.

Maintain meticulous documentation of experimental procedures, results, and data analysis in compliance with Good Laboratory Practices (GLP) and regulatory requirements.

Contribute to the preparation of regulatory submissions, including study reports, data summaries, and regulatory documents, as required.

Mentor and provide guidance to junior scientists and research associates, fostering a culture of scientific excellence and professional development within the team.

Qualifications:

Ph.D. or Master's degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.

Minimum of 10 years of hands-on experience in mass spectrometry-based bioanalysis, with a focus on quantitative analysis of small molecules or biologics in biological matrices.

Proven expertise in LC-MS/MS instrumentation and method development for bioanalytical applications, preferably in oncology drug development.

Strong understanding of analytical method validation principles and regulatory guidelines (e.g., FDA, EMA) for bioanalytical method validation.

Demonstrated proficiency in sample preparation techniques for the extraction and purification of small molecules or biologics from complex biological matrices.

Excellent problem-solving skills, with the ability to troubleshoot technical issues and implement effective solutions.

Outstanding organizational skills, attention to detail, and the ability to manage multiple projects simultaneously in a fast-paced environment.

Strong communication and interpersonal skills, with the ability to collaborate effectively within multidisciplinary teams.

Previous experience in oncology drug development and familiarity with ADC pharmacokinetics are advantageous.

Commitment to quality, accuracy, and compliance with regulatory requirements.

Onsite work is mandatory.

If you are a seasoned scientist with a proven track record in mass spectrometry and a passion for advancing oncology drug development, we invite you to apply for this exciting opportunity to lead our efforts in ADC PK testing.

Language Ability

Ability to read and comprehend simple instructions, short correspondence, and memos. Ability to write simple correspondence. Ability to effectively present information in one-on-one and small group situations to customers, clients, and other employees of the organization. Strong interpersonal, communication and collaboration skills to connect with internal and external CROs.

Math Ability

Ability to calculate figures and amounts such as discounts, interest, commissions, proportions, percentages, area, circumference, and volume. Ability to apply concepts of basic algebra and geometry.

Reasoning Ability

Ability to interpret a variety of instructions furnished in written, oral, diagram, or schedule form. Strong scientific, medical, and analytical abilities with innovative, solution-oriented style.

Computer Skills

Proficiency with Microsoft Word, Excel, and PowerPoint required. Proficiency with email required.

Certificates and Licenses

None required.

Supervisory Responsibilities

This job may have supervisory responsibilities.

Work Environment:

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

This individual will work in cell culture laboratory alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to operate standard laboratory and business equipment.

The hiring pay range for this position is $100,000 - $180,000 per year based on skills, education, and experience relevant to the role.

SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer. Interested applicants should send their CV and cover letter to