Principal Scientist, Protein Engineering

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company's Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a highly motivated protein engineer to join the biotherapeutics discovery group. The candidate must have demonstrable experience with antibody discovery and protein engineering programs in a biologics discovery setting.

Responsibilities

Expertise in protein and antibody engineering in the discovery and preclinical development of biotherapeutic candidates. Assist in evaluating new technologies to stay at the cutting edge of biologics discovery, production, and characterization.

Play a key role in assessing protein structure and function as applied toward the evaluation of biologics for protein design and engineering.

Present your findings and ideas to an interdisciplinary team with a wide range of technical backgrounds.

Qualifications

PhD in Molecular Biology, Structural Biology, Biophysics, Biochemistry, or related disciplines and 8 years or more of experience in the biotechnology or pharmaceutical industry

Manage all aspects of protein and antibody expression, purification, and characterization to support the preclinical discovery and development efforts of the biotherapeutics group.

Experience managing external CROs and vendors for protein engineering work.

Demonstrable experience in antibody discovery, antibody engineering, or the engineering of other proteins.

Familiarity with various antibody formats and scaffolds including, but not limited to fusion proteins, bi-specific antibodies, single-domain antibodies (VHH), and bi-paratopic antibodies.

Experience in mammalian cell culture and protein expression systems.

Self-starter, strong collaborative skills working in cross-functional teams and a start-up environment.

The expected base pay range for this position is $150,000 - $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

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