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Biophysical Scientist

Artech Information Systems
Cambridge, Massachusetts, United States
February 20, 2018


Job Title: Associate Scientist III, Technical Development

Job ID: BIIBJP00009403

Location: Cambridge, MA

Duration: 6 Months

Position Summary

The Biophysical Characterization group within the Analytical Development department at Client is seeking a motivated and energetic person to develop biophysical methods for the characterization of gene therapy products at Client. The group focuses on developing novel methods for the characterization of biopharmaceuticals, interfaces with other groups at Client to help them answer structural/functional questions about their biotherapeutic samples, and supports internal and partner projects to deliver required biophysical data that is an integral part of regulatory filings.

The advent of adeno-associated viruses (AAV) as a delivery mechanism for gene therapy requires evaluation of new biophysical tools or development/transformation of existing ones to provide product understanding of these complex biopharmaceuticals. The co-op will evaluate new technologies for the characterization of AAV aggregates and the quantitation of empty-to-full particle ratios. Specifically, the co-op will evaluate the applicability of adjacent-flow field flow fractionation (AFFFF or AF4) for the separation of AAV particles from their aggregates and study the applicability of light scattering techniques (dynamic and static light scattering) for the quantitation of empty and full particles.

Key Responsibilities:

• Work with external vendor to evaluate their AF4 technology and its ability to separate AAV particles from its aggregates.

• Evaluate different light scattering technologies for the quantitation of empty-to-full particle ratios.

• Design experiments, write protocols, perform biophysical analyses, analyze the data, and generate reports.

• Attend internal Client meetings focused on the biophysical characterization of biomolecules.

• Work with external partners to develop new biophysical methods.


• Legal authorization to work in the U.S.

• Theoretical background in separation and light scattering technologies is preferred.


• BS with 3 years of experience or MS with no experience.

• Desired majors include: biochemistry, biophysics, biotechnology, biochemical engineering or equivalent