Computational Protein Engineer

Senior Scientist, Protein Engineering

Our client is a leading biotech firm advancing innovative antibody and protein engineering programs.

They seek a Senior Scientist, Protein Engineering to lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.

The ideal candidate will take on the following responsibilities:

Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design

Drive protein expression, purification, and characterization workflows across multiple formats

Design and execute binding and functional assays to evaluate and iterate on engineered proteins

Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs

Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies

Manage CRO partnerships including experimental design, vendor communication, and internal reporting

The ideal candidate will possess the following qualifications:

PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience

Hands-on expertise in protein expression, purification, and characterization

Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities

Peer-reviewed publications and/or patents in antibody or protein engineering

Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus

Proven ability to lead technical teams and manage complex, multi-faceted projects

Outstanding written and verbal communication skills